hy-p0227 Search Results


shu9119  (MedChemExpress)
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MedChemExpress shu9119
POMC-melanocortin system participated in the effects of cromolyn sodium on energy balance. (A, B) Immunofluorescence staining and quantification of α-MSH in the hypothalamic PVN nucleus in brain slices from control and cromolyn sodium-injected mice. (C, D) Immunofluorescence co-staining and quantification of α-MSH in the hypothalamic DMH nucleus in brain slices from control and cromolyn sodium-injected mice. (E, F) Immunofluorescence staining and quantification of c-Fos in brain slices from control and cromolyn sodium-injected mice, which were i.c.v. saline control and <t>SHU9119.</t> (G, H) Food intake, oxygen consumption, and energy expenditure in control and cromolyn sodium-injected mice, as well as saline and SHU9119. ns, not significant. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, two-tailed Student’s t-test (B, D) , two-way ANOVA with Bonferroni’s post hoc test (F-I) .
Shu9119, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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POMC-melanocortin system participated in the effects of cromolyn sodium on energy balance. (A, B) Immunofluorescence staining and quantification of α-MSH in the hypothalamic PVN nucleus in brain slices from control and cromolyn sodium-injected mice. (C, D) Immunofluorescence co-staining and quantification of α-MSH in the hypothalamic DMH nucleus in brain slices from control and cromolyn sodium-injected mice. (E, F) Immunofluorescence staining and quantification of c-Fos in brain slices from control and cromolyn sodium-injected mice, which were i.c.v. saline control and SHU9119. (G, H) Food intake, oxygen consumption, and energy expenditure in control and cromolyn sodium-injected mice, as well as saline and SHU9119. ns, not significant. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, two-tailed Student’s t-test (B, D) , two-way ANOVA with Bonferroni’s post hoc test (F-I) .

Journal: Frontiers in Endocrinology

Article Title: Mast cell promotes obesity by activating microglia in hypothalamus

doi: 10.3389/fendo.2025.1544213

Figure Lengend Snippet: POMC-melanocortin system participated in the effects of cromolyn sodium on energy balance. (A, B) Immunofluorescence staining and quantification of α-MSH in the hypothalamic PVN nucleus in brain slices from control and cromolyn sodium-injected mice. (C, D) Immunofluorescence co-staining and quantification of α-MSH in the hypothalamic DMH nucleus in brain slices from control and cromolyn sodium-injected mice. (E, F) Immunofluorescence staining and quantification of c-Fos in brain slices from control and cromolyn sodium-injected mice, which were i.c.v. saline control and SHU9119. (G, H) Food intake, oxygen consumption, and energy expenditure in control and cromolyn sodium-injected mice, as well as saline and SHU9119. ns, not significant. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, two-tailed Student’s t-test (B, D) , two-way ANOVA with Bonferroni’s post hoc test (F-I) .

Article Snippet: For administration of the SHU9119 (MCE, HY-P0227), lateral ventricle-cannulated HFD mice were briefly fasted, and received i.c.v. administration of SHU9119 (1μg,1 μL) or 0.9% NaCl as a control.

Techniques: Immunofluorescence, Staining, Control, Injection, Saline, Two Tailed Test