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ara290  (MedChemExpress)
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MedChemExpress ara290
The enhanced capacity of macrophage efferocytosis could promote M2 macrophage polarization in inflammatory conditions. ( A ) The co-cultured cell model of apoptotic neutrophils and macrophages under Pg. LPS+IFN-γ-stimulated conditions with treatment of 100 nM, 300 nM and 600 nM <t>ARA290</t> detected by immunofluorescence staining. Yellow arrow: the engulfment of apoptotic cell by macrophages; white arrow: the apoptotic cells that had not been engulfed by macrophages. Green, apoptotic neutrophils; red, macrophages; blue, DAPI. Scale bar of upper figure = 100 μm, scale bar of lower figure = 25 μm. ( B – E ) Representative immunoblotting images of different antibodies as indicated and their quantification. ( F , G ) The expression of CD86 and CD163 was detected via RT-PCR. ( H ) The M1/M2 ration was calculated according to the expression of CD86 and CD163. * p < 0.05, ** p < 0.01, *** p < 0.001, ns. p > 0.05.
Ara290, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The enhanced capacity of macrophage efferocytosis could promote M2 macrophage polarization in inflammatory conditions. ( A ) The co-cultured cell model of apoptotic neutrophils and macrophages under Pg. LPS+IFN-γ-stimulated conditions with treatment of 100 nM, 300 nM and 600 nM ARA290 detected by immunofluorescence staining. Yellow arrow: the engulfment of apoptotic cell by macrophages; white arrow: the apoptotic cells that had not been engulfed by macrophages. Green, apoptotic neutrophils; red, macrophages; blue, DAPI. Scale bar of upper figure = 100 μm, scale bar of lower figure = 25 μm. ( B – E ) Representative immunoblotting images of different antibodies as indicated and their quantification. ( F , G ) The expression of CD86 and CD163 was detected via RT-PCR. ( H ) The M1/M2 ration was calculated according to the expression of CD86 and CD163. * p < 0.05, ** p < 0.01, *** p < 0.001, ns. p > 0.05.

Journal: International Journal of Molecular Sciences

Article Title: The Role of Macrophage Efferocytosis in the Pathogenesis of Apical Periodontitis

doi: 10.3390/ijms25073854

Figure Lengend Snippet: The enhanced capacity of macrophage efferocytosis could promote M2 macrophage polarization in inflammatory conditions. ( A ) The co-cultured cell model of apoptotic neutrophils and macrophages under Pg. LPS+IFN-γ-stimulated conditions with treatment of 100 nM, 300 nM and 600 nM ARA290 detected by immunofluorescence staining. Yellow arrow: the engulfment of apoptotic cell by macrophages; white arrow: the apoptotic cells that had not been engulfed by macrophages. Green, apoptotic neutrophils; red, macrophages; blue, DAPI. Scale bar of upper figure = 100 μm, scale bar of lower figure = 25 μm. ( B – E ) Representative immunoblotting images of different antibodies as indicated and their quantification. ( F , G ) The expression of CD86 and CD163 was detected via RT-PCR. ( H ) The M1/M2 ration was calculated according to the expression of CD86 and CD163. * p < 0.05, ** p < 0.01, *** p < 0.001, ns. p > 0.05.

Article Snippet: Following the pulp operation, ARA290 (120 μg/kg, MCE, Monmouth Junction, NJ, USA) was intraperitoneally injected into mice three times per week [ ].

Techniques: Cell Culture, Immunofluorescence, Staining, Western Blot, Expressing, Reverse Transcription Polymerase Chain Reaction

ARA290, the agonist of macrophage efferocytosis, could suppress apical periodontitis progression. ( A ) Representative radiographs of mandible first molar of experimental apical periodontitis. The images were taken using three-dimensional micro-Ct at three different views: coronal, sagittal and horizontal images. ( B ) The body weight of mice in different groups. ( C ) Quantification of bone loss volume in each group. ** p < 0.01, **** p < 0.001, ns. p > 0.05 ( D ) HE staining displayed bone loss and inflammatory status in periapical tissue in different group set. Scale bar of upper figure = 200 μm, scale bar of lower figure = 50 μm.

Journal: International Journal of Molecular Sciences

Article Title: The Role of Macrophage Efferocytosis in the Pathogenesis of Apical Periodontitis

doi: 10.3390/ijms25073854

Figure Lengend Snippet: ARA290, the agonist of macrophage efferocytosis, could suppress apical periodontitis progression. ( A ) Representative radiographs of mandible first molar of experimental apical periodontitis. The images were taken using three-dimensional micro-Ct at three different views: coronal, sagittal and horizontal images. ( B ) The body weight of mice in different groups. ( C ) Quantification of bone loss volume in each group. ** p < 0.01, **** p < 0.001, ns. p > 0.05 ( D ) HE staining displayed bone loss and inflammatory status in periapical tissue in different group set. Scale bar of upper figure = 200 μm, scale bar of lower figure = 50 μm.

Article Snippet: Following the pulp operation, ARA290 (120 μg/kg, MCE, Monmouth Junction, NJ, USA) was intraperitoneally injected into mice three times per week [ ].

Techniques: Micro-CT, Staining

ARA290 promotes M2 macrophage polarization in periapical region. ( A – H ) The expression and quantification of Mertk, Gas6, c-caspase-3, CD68 and IL-1β in periapical tissue in different groups. Scale bar = 50 μm. ( I ) The M1/M2 ration was calculated according to the expression of CD86 and CD163. * p < 0.05, *** p < 0.005, **** p < 0.001 ( J ) Mertk-CD68 and Gas6-CD68 double labeling (scale bar = 20 μm) in each group. Green,c-Cas 3; red, Mertk/Gas 6; blue, DAPI.

Journal: International Journal of Molecular Sciences

Article Title: The Role of Macrophage Efferocytosis in the Pathogenesis of Apical Periodontitis

doi: 10.3390/ijms25073854

Figure Lengend Snippet: ARA290 promotes M2 macrophage polarization in periapical region. ( A – H ) The expression and quantification of Mertk, Gas6, c-caspase-3, CD68 and IL-1β in periapical tissue in different groups. Scale bar = 50 μm. ( I ) The M1/M2 ration was calculated according to the expression of CD86 and CD163. * p < 0.05, *** p < 0.005, **** p < 0.001 ( J ) Mertk-CD68 and Gas6-CD68 double labeling (scale bar = 20 μm) in each group. Green,c-Cas 3; red, Mertk/Gas 6; blue, DAPI.

Article Snippet: Following the pulp operation, ARA290 (120 μg/kg, MCE, Monmouth Junction, NJ, USA) was intraperitoneally injected into mice three times per week [ ].

Techniques: Expressing, Labeling