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nootkatone  (MedChemExpress)
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MedChemExpress nootkatone
Fig. 1 NKT inhibited the proliferation and growth of GBM cells in vitro. (A, B) The cell viability of C6 cells and U251 cells treated with gradient concentra tions (0 µM, 100 µM, 200 µM, 300 µM) of <t>nootkatone</t> detected by CCK8 assays (n = 5/group, one-way ANOVA, Tukey’s test was performed for the multiple comparison). (C, E) Cell colony formation of C6 cells and U251 cells treated with DMSO or NKT (200 µM) for approximately 7 days. Scale bar, 500 μm. (D, F) Quantitative analysis of colony number of C6 cells (D) and U251 cells (F) (the surviving colonies > 10 cells) as shown in (C, E) (n = 3/group, t-test). (G, I) Representative images of PH3 staining (red) in C6 cells and U251 cells after being treated with DMSO or 200 µM nootkatone for 48 h. Scale bars, 50 μm. (H, K) Quantitative analysis of the percentages of PH3+ cells over total C6 cells and U251 cells in one field as shown in (G, I) (n = 5/group, t-test). Data were mean ± SEM. *P < 0.05, **P < 0.01
Nootkatone, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 1 NKT inhibited the proliferation and growth of GBM cells in vitro. (A, B) The cell viability of C6 cells and U251 cells treated with gradient concentra tions (0 µM, 100 µM, 200 µM, 300 µM) of nootkatone detected by CCK8 assays (n = 5/group, one-way ANOVA, Tukey’s test was performed for the multiple comparison). (C, E) Cell colony formation of C6 cells and U251 cells treated with DMSO or NKT (200 µM) for approximately 7 days. Scale bar, 500 μm. (D, F) Quantitative analysis of colony number of C6 cells (D) and U251 cells (F) (the surviving colonies > 10 cells) as shown in (C, E) (n = 3/group, t-test). (G, I) Representative images of PH3 staining (red) in C6 cells and U251 cells after being treated with DMSO or 200 µM nootkatone for 48 h. Scale bars, 50 μm. (H, K) Quantitative analysis of the percentages of PH3+ cells over total C6 cells and U251 cells in one field as shown in (G, I) (n = 5/group, t-test). Data were mean ± SEM. *P < 0.05, **P < 0.01

Journal: Molecular medicine (Cambridge, Mass.)

Article Title: Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway.

doi: 10.1186/s10020-025-01064-1

Figure Lengend Snippet: Fig. 1 NKT inhibited the proliferation and growth of GBM cells in vitro. (A, B) The cell viability of C6 cells and U251 cells treated with gradient concentra tions (0 µM, 100 µM, 200 µM, 300 µM) of nootkatone detected by CCK8 assays (n = 5/group, one-way ANOVA, Tukey’s test was performed for the multiple comparison). (C, E) Cell colony formation of C6 cells and U251 cells treated with DMSO or NKT (200 µM) for approximately 7 days. Scale bar, 500 μm. (D, F) Quantitative analysis of colony number of C6 cells (D) and U251 cells (F) (the surviving colonies > 10 cells) as shown in (C, E) (n = 3/group, t-test). (G, I) Representative images of PH3 staining (red) in C6 cells and U251 cells after being treated with DMSO or 200 µM nootkatone for 48 h. Scale bars, 50 μm. (H, K) Quantitative analysis of the percentages of PH3+ cells over total C6 cells and U251 cells in one field as shown in (G, I) (n = 5/group, t-test). Data were mean ± SEM. *P < 0.05, **P < 0.01

Article Snippet: Nootkatone was purchased from MedChemExpress (#HY-N2195).

Techniques: In Vitro, Comparison, Staining