hy-n2037a Search Results


norcoclaurine  (MedChemExpress)
94
MedChemExpress norcoclaurine
The acquisition of active ingredients of shenfu injection and the molecular docking analysis of the active ingredients of shenfu injection and the targets NLRP3 and Caspase 1. ( A ) Cytoscape3.7.0 was applied to visualize the interaction between the active components of shenfu injection and the targets NLRP3 and Caspase 1, and to construct the compound-ingredient-target diagram. ( B and C ) PyMOL 2.5.4 was utilized to visualize the molecular docking results of <t>(R)-norcoclaurine</t> with NLRP3 ( B ) and ignavine with Caspase 1 ( C ). NLRP3, nucleotide binding oligomerization domain-like receptor family pyrin domain protein 3.
Norcoclaurine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hy-n2037a/Higenamine+hydrochloride/pmc11488353-219-53-55
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The acquisition of active ingredients of shenfu injection and the molecular docking analysis of the active ingredients of shenfu injection and the targets NLRP3 and Caspase 1. ( A ) Cytoscape3.7.0 was applied to visualize the interaction between the active components of shenfu injection and the targets NLRP3 and Caspase 1, and to construct the compound-ingredient-target diagram. ( B and C ) PyMOL 2.5.4 was utilized to visualize the molecular docking results of (R)-norcoclaurine with NLRP3 ( B ) and ignavine with Caspase 1 ( C ). NLRP3, nucleotide binding oligomerization domain-like receptor family pyrin domain protein 3.

Journal: Journal of Inflammation Research

Article Title: Shenfu Injection Mediated NLRP3/Caspase 1 Through (R)-Norcoclaurinee Alleviates Sepsis-Induced Cognitive Dysfunction

doi: 10.2147/JIR.S481171

Figure Lengend Snippet: The acquisition of active ingredients of shenfu injection and the molecular docking analysis of the active ingredients of shenfu injection and the targets NLRP3 and Caspase 1. ( A ) Cytoscape3.7.0 was applied to visualize the interaction between the active components of shenfu injection and the targets NLRP3 and Caspase 1, and to construct the compound-ingredient-target diagram. ( B and C ) PyMOL 2.5.4 was utilized to visualize the molecular docking results of (R)-norcoclaurine with NLRP3 ( B ) and ignavine with Caspase 1 ( C ). NLRP3, nucleotide binding oligomerization domain-like receptor family pyrin domain protein 3.

Article Snippet: To detect the cell viability, BV-2 cells (3000 cells/well in 96-well plate) were divided four groups, Control group (normal cultivation), lipopolysaccharide (LPS) group (treated with LPS), LPS + DMSO group (treated with LPS and dimethyl sulfoxide (DMSO)), and LPS + norcoclaurine (treated with 200 ng/mL LPS (L2880, Sigma, St. Louis, MO, USA) and norcoclaurine (HY-N2037A, Med Chem Express, Shanghai, China).

Techniques: Injection, Construct, Binding Assay

Norcoclaurine increases the cell viability and decreases inflammation and apoptosis. BV-2 cells were treated with/without LPS/norcoclaurine for 24 h. ( A ) Cell viability detection using Cell Counting Kit-8. ( B ) Western blot analysis of Caspase 1, NLRP3, IL-18, and IL-1β levels. ( C ) The relative density analysis of ( B ). *P < 0.05, **P < 0.01, ***P < 0.001.

Journal: Journal of Inflammation Research

Article Title: Shenfu Injection Mediated NLRP3/Caspase 1 Through (R)-Norcoclaurinee Alleviates Sepsis-Induced Cognitive Dysfunction

doi: 10.2147/JIR.S481171

Figure Lengend Snippet: Norcoclaurine increases the cell viability and decreases inflammation and apoptosis. BV-2 cells were treated with/without LPS/norcoclaurine for 24 h. ( A ) Cell viability detection using Cell Counting Kit-8. ( B ) Western blot analysis of Caspase 1, NLRP3, IL-18, and IL-1β levels. ( C ) The relative density analysis of ( B ). *P < 0.05, **P < 0.01, ***P < 0.001.

Article Snippet: To detect the cell viability, BV-2 cells (3000 cells/well in 96-well plate) were divided four groups, Control group (normal cultivation), lipopolysaccharide (LPS) group (treated with LPS), LPS + DMSO group (treated with LPS and dimethyl sulfoxide (DMSO)), and LPS + norcoclaurine (treated with 200 ng/mL LPS (L2880, Sigma, St. Louis, MO, USA) and norcoclaurine (HY-N2037A, Med Chem Express, Shanghai, China).

Techniques: Cell Counting, Western Blot