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rhamnocitrin  (MedChemExpress)
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MedChemExpress rhamnocitrin
Validation of IKKβ Targeting by <t>Rhamnocitrin</t> and Toralactone. A, B WB was used to detect the expression of IKKβ in HEK293T cells transfected with the overexpression IKKβ (OE-IKKβ) plasmid, and their statistics (n = 3, per group). C–F WB was used to detect the expressions of p-IKKβ and IKKβ in OE-IKKβ HEK293T cells after 24 h of intervention with different concentrations of TNF-α, and their statistics (n = 3, per group). G–J The expression of p-IKKβ and IKKβ in OE-IKKβ HEK293T cells treated with Rhamnocitrin and Toralactone simultaneously with 10 ng/mL TNF-α was detected by WB, and their statistics (n = 3, per group). K Protein–Ligand Interaction Profiler (PLIP) analysis of Rhamnocitrin and Toralactone with IKKβ. L MD simulation analysis of IKKβ and Rhamnocitrin/Toralactone complex at 100 ns. M Gibbs free energy analysis of IKKβ-Rhamnocitrin/Toralactone complexes. N Binding kinetics of Rhamnocitrin and Toralactone with IKKβ by SPR. One-way ANOVA with Dunnett’s multiple comparisons test. * p < 0.05, ** p < 0.01, compared with NC group, TNF-α 0 ng/mL group or TNF-α 10 ng/mL group
Rhamnocitrin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rhamnocitrin - by Bioz Stars, 2026-10
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Validation of IKKβ Targeting by Rhamnocitrin and Toralactone. A, B WB was used to detect the expression of IKKβ in HEK293T cells transfected with the overexpression IKKβ (OE-IKKβ) plasmid, and their statistics (n = 3, per group). C–F WB was used to detect the expressions of p-IKKβ and IKKβ in OE-IKKβ HEK293T cells after 24 h of intervention with different concentrations of TNF-α, and their statistics (n = 3, per group). G–J The expression of p-IKKβ and IKKβ in OE-IKKβ HEK293T cells treated with Rhamnocitrin and Toralactone simultaneously with 10 ng/mL TNF-α was detected by WB, and their statistics (n = 3, per group). K Protein–Ligand Interaction Profiler (PLIP) analysis of Rhamnocitrin and Toralactone with IKKβ. L MD simulation analysis of IKKβ and Rhamnocitrin/Toralactone complex at 100 ns. M Gibbs free energy analysis of IKKβ-Rhamnocitrin/Toralactone complexes. N Binding kinetics of Rhamnocitrin and Toralactone with IKKβ by SPR. One-way ANOVA with Dunnett’s multiple comparisons test. * p < 0.05, ** p < 0.01, compared with NC group, TNF-α 0 ng/mL group or TNF-α 10 ng/mL group

Journal: Chinese Medicine

Article Title: Guiqi Baizhu prescription attenuates 5-FU-induced intestinal mucositis by targeting IKKβ to inhibit M1 macrophage polarization

doi: 10.1186/s13020-026-01406-z

Figure Lengend Snippet: Validation of IKKβ Targeting by Rhamnocitrin and Toralactone. A, B WB was used to detect the expression of IKKβ in HEK293T cells transfected with the overexpression IKKβ (OE-IKKβ) plasmid, and their statistics (n = 3, per group). C–F WB was used to detect the expressions of p-IKKβ and IKKβ in OE-IKKβ HEK293T cells after 24 h of intervention with different concentrations of TNF-α, and their statistics (n = 3, per group). G–J The expression of p-IKKβ and IKKβ in OE-IKKβ HEK293T cells treated with Rhamnocitrin and Toralactone simultaneously with 10 ng/mL TNF-α was detected by WB, and their statistics (n = 3, per group). K Protein–Ligand Interaction Profiler (PLIP) analysis of Rhamnocitrin and Toralactone with IKKβ. L MD simulation analysis of IKKβ and Rhamnocitrin/Toralactone complex at 100 ns. M Gibbs free energy analysis of IKKβ-Rhamnocitrin/Toralactone complexes. N Binding kinetics of Rhamnocitrin and Toralactone with IKKβ by SPR. One-way ANOVA with Dunnett’s multiple comparisons test. * p < 0.05, ** p < 0.01, compared with NC group, TNF-α 0 ng/mL group or TNF-α 10 ng/mL group

Article Snippet: Rhamnocitrin (HY-N1353), Toralactone (HY-N7617), Carvarol (HY-N0711R), Scopoletin (HY-N0342), and TNF-α (HY-P1875) were procured from MedChem Express (Monmouth Junction, NJ, USA).

Techniques: Biomarker Discovery, Expressing, Transfection, Over Expression, Plasmid Preparation, Binding Assay