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micheliolide  (MedChemExpress)
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Activation of EGFR signaling promotes PKM2 nuclear translocation in NPC cells. (A) Transient silencing of EGFR leads to reduced nuclear PKM2 protein in HK1 and FaDu cells. The immune-intensity levels of cytoplasmic or nuclear PKM2 protein were normalized to GAPDH or histone 3 (H3), respectively. (B) Exogenous EGF treatment (100 ng/ml) promotes PKM2 nuclear translocation. (C, D) Depletion of PKM2 impairs EGF stimulated NPC cell migration (C) and invasion (D). (E, F) Inhibition of PKM2 nuclear translocation by <t>micheliolide</t> (MCL) treatment suppresses EGF-stimulated NPC cell migration (E) and invasion (F). * p < 0.05. ** p < 0.01. *** p < 0.001.
Micheliolide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Activation of EGFR signaling promotes PKM2 nuclear translocation in NPC cells. (A) Transient silencing of EGFR leads to reduced nuclear PKM2 protein in HK1 and FaDu cells. The immune-intensity levels of cytoplasmic or nuclear PKM2 protein were normalized to GAPDH or histone 3 (H3), respectively. (B) Exogenous EGF treatment (100 ng/ml) promotes PKM2 nuclear translocation. (C, D) Depletion of PKM2 impairs EGF stimulated NPC cell migration (C) and invasion (D). (E, F) Inhibition of PKM2 nuclear translocation by micheliolide (MCL) treatment suppresses EGF-stimulated NPC cell migration (E) and invasion (F). * p < 0.05. ** p < 0.01. *** p < 0.001.

Journal: Carcinogenesis

Article Title: EGFR-PKM2 signaling promotes the metastatic potential of nasopharyngeal carcinoma through induction of FOSL1 and ANTXR2

doi: 10.1093/carcin/bgz180

Figure Lengend Snippet: Activation of EGFR signaling promotes PKM2 nuclear translocation in NPC cells. (A) Transient silencing of EGFR leads to reduced nuclear PKM2 protein in HK1 and FaDu cells. The immune-intensity levels of cytoplasmic or nuclear PKM2 protein were normalized to GAPDH or histone 3 (H3), respectively. (B) Exogenous EGF treatment (100 ng/ml) promotes PKM2 nuclear translocation. (C, D) Depletion of PKM2 impairs EGF stimulated NPC cell migration (C) and invasion (D). (E, F) Inhibition of PKM2 nuclear translocation by micheliolide (MCL) treatment suppresses EGF-stimulated NPC cell migration (E) and invasion (F). * p < 0.05. ** p < 0.01. *** p < 0.001.

Article Snippet: Cells were treated with recombinant EGF (SinoBiological, Inc., Beijing, China) at 100 ng/ml or micheliolide (MCL, MedChemExpress, Beijing, China) at 5 μM or cetuximab (Erbitux ® , Merck KGaA, Darmstadt, Germany) at 20 ng/ml.

Techniques: Activation Assay, Translocation Assay, Migration, Inhibition