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Image Search Results

Journal: Stem Cell Research & Therapy
Article Title: Exosomes derived from human umbilical cord mesenchymal stem cells inhibit vein graft intimal hyperplasia and accelerate reendothelialization by enhancing endothelial function
doi: 10.1186/s13287-020-01639-1
Figure Lengend Snippet: hucMSC-exosomes inhibited intimal hyperplasia and luminal stenosis in arterialized vein grafts. a Representative ultrasound images of vein grafts from the PBS group (left panel) and exosome group (right panel). Quantification of the luminal diameter ( b ) and peak-systolic velocity ( c ) in vein grafts. d Histologic images of haematoxylin and eosin staining (HE) staining in vein grafts from the normal vein group (left panel), PBS group (middle panel), and exosome group (right panel). e Quantification of the neointimal thickness in vein grafts. f Immunohistochemical staining of matrix metalloproteinase 2 (MMP-2) in vein grafts from the PBS group (left panel) and exosome group (right panel). g Immunohistochemical staining of matrix metalloproteinase 9 (MMP-9) in vein grafts from the PBS group (left panel) and exosome group (right panel). h Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) in vein grafts from the PBS group (left panel) and exosome group (right panel). i Quantitative analysis of PCNA-positive index in vein grafts. The PCNA-positive index was quantified as the percentage of total nuclei in the neointima. Scale bar is 200 μm in panels d , f , g , and h . The results are presented as the mean ± SD, n = 6 for each group. An asterisk represents statistically significant difference compared with the PBS group ( P < 0.05). Number sign represents statistically significant difference compared with the normal vein group ( P < 0.05)
Article Snippet:
Techniques: Staining, Immunohistochemical staining