htr7 Search Results


gene exp htr7 hs04194798 s1  (Thermo Fisher)
91
Thermo Fisher gene exp htr7 hs04194798 s1
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
Gene Exp Htr7 Hs04194798 S1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pmc07553312-74-21--1?v=Thermo+Fisher
Average 91 stars, based on 1 article reviews
gene exp htr7 hs04194798 s1 - by Bioz Stars, 2026-07
91/100 stars
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5ht7 receptor htr7 extracellular blocking peptide  (Alomone Labs)
93
Alomone Labs 5ht7 receptor htr7 extracellular blocking peptide
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
5ht7 Receptor Htr7 Extracellular Blocking Peptide, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pm39833622-98-16-31?v=Alomone+Labs
Average 93 stars, based on 1 article reviews
5ht7 receptor htr7 extracellular blocking peptide - by Bioz Stars, 2026-07
93/100 stars
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gfp tagged human htr7 plasmid  (OriGene)
90
OriGene gfp tagged human htr7 plasmid
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
Gfp Tagged Human Htr7 Plasmid, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/morita_takeshi__2016__genetic_variation_as_a_tool_for_identifying_novel_transducers_of_itch-237-9-14?v=OriGene
Average 90 stars, based on 1 article reviews
gfp tagged human htr7 plasmid - by Bioz Stars, 2026-07
90/100 stars
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serotonin receptor 7 5 ht7r  (OriGene)
90
OriGene serotonin receptor 7 5 ht7r
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
Serotonin Receptor 7 5 Ht7r, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pm16445449-25-57-61?v=OriGene
Average 90 stars, based on 1 article reviews
serotonin receptor 7 5 ht7r - by Bioz Stars, 2026-07
90/100 stars
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n rrid ab 1611252 cooh terminus polyclonal ihc liver femoral vessels portal vein open in a separate window wt wild type  (OriGene)
90
OriGene n rrid ab 1611252 cooh terminus polyclonal ihc liver femoral vessels portal vein open in a separate window wt wild type
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
N Rrid Ab 1611252 Cooh Terminus Polyclonal Ihc Liver Femoral Vessels Portal Vein Open In A Separate Window Wt Wild Type, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pmc06689730-275-135-132?v=OriGene
Average 90 stars, based on 1 article reviews
n rrid ab 1611252 cooh terminus polyclonal ihc liver femoral vessels portal vein open in a separate window wt wild type - by Bioz Stars, 2026-07
90/100 stars
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anti htr7  (Proteintech)
93
Proteintech anti htr7
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
Anti Htr7, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pmc10694672-18-0-2?v=Proteintech
Average 93 stars, based on 1 article reviews
anti htr7 - by Bioz Stars, 2026-07
93/100 stars
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5–htr7  (PrimerDesign Inc)
90
PrimerDesign Inc 5–htr7
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
5–Htr7, supplied by PrimerDesign Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pmc12147198-0-0-2?v=PrimerDesign+Inc
Average 90 stars, based on 1 article reviews
5–htr7 - by Bioz Stars, 2026-07
90/100 stars
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anti-htr7 polyclonal antibody  (MyBiosource Biotechnology)
90
MyBiosource Biotechnology anti-htr7 polyclonal antibody
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
Anti Htr7 Polyclonal Antibody, supplied by MyBiosource Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pm39455564-274-0-5?v=MyBiosource+Biotechnology
Average 90 stars, based on 1 article reviews
anti-htr7 polyclonal antibody - by Bioz Stars, 2026-07
90/100 stars
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r5-ht7 receptor expressing plasmid at msu rat htr7 (r5-ht7; p32305) cdna/orf clone  (NovoPro Biosciences Inc)
90
NovoPro Biosciences Inc r5-ht7 receptor expressing plasmid at msu rat htr7 (r5-ht7; p32305) cdna/orf clone
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
R5 Ht7 Receptor Expressing Plasmid At Msu Rat Htr7 (R5 Ht7; P32305) Cdna/Orf Clone, supplied by NovoPro Biosciences Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pm37071157-52-8-17?v=NovoPro+Biosciences+Inc
Average 90 stars, based on 1 article reviews
r5-ht7 receptor expressing plasmid at msu rat htr7 (r5-ht7; p32305) cdna/orf clone - by Bioz Stars, 2026-07
90/100 stars
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htr7 sirna  (Synbio Technologies LLC)
90
Synbio Technologies LLC htr7 sirna
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
Htr7 Sirna, supplied by Synbio Technologies LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pm39247815-95-0-16?v=Synbio+Technologies+LLC
Average 90 stars, based on 1 article reviews
htr7 sirna - by Bioz Stars, 2026-07
90/100 stars
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pmcherry-htr7  (Hamamatsu)
90
Hamamatsu pmcherry-htr7
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
Pmcherry Htr7, supplied by Hamamatsu, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/pm30578315-205-8-4?v=Hamamatsu
Average 90 stars, based on 1 article reviews
pmcherry-htr7 - by Bioz Stars, 2026-07
90/100 stars
  Buy from Supplier
anti-5ht7 receptor/htr7 -fitc antibody  (Alomone Labs)
93
Alomone Labs anti-5ht7 receptor/htr7 -fitc antibody
(A) Quantification of <t>HTR7</t> expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.
Anti 5ht7 Receptor/Htr7 Fitc Antibody, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/htr7/custom-asr-037-f-39833622?v=Alomone+Labs
Average 93 stars, based on 1 article reviews
anti-5ht7 receptor/htr7 -fitc antibody - by Bioz Stars, 2026-07
93/100 stars
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Image Search Results


(A) Quantification of HTR7 expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.

Journal: PLoS ONE

Article Title: Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia

doi: 10.1371/journal.pone.0240120

Figure Lengend Snippet: (A) Quantification of HTR7 expression in primary granulocytes (neutrophils, eosinophils, basophils), monocytes, and selected cell lines by RQ-PCR. (B) Genomic profiling data demonstrated a duplication in EOL-1 which encompassed the flanking regulatory region of HTR7. (C) A genomic map of the locus for HTR7 was taken from the UCSC genome browser, showing potential transcription factor binding sites. The indicated duplication detected in EOL-1 containes a potential HMX1-site. (D) SiRNA-mediated knockdown of HMX2 (left) and HMX3 (middle) resulted in reduced expression levels of HTR7, indicating an activating impact. Asterisks indicate calculated p-values obtained by t-Test analysis of controls (siCTR) and siRNA-targeted knockdown. Forced expression of HMX2 in HL-60 resulted in elevated transcript levels of HTR7 (right), supporting an activating impact. (E) Reporter-gene assay in NIH-3T3 cells using a fragment containing the identified HMX1-site. Forced expression of HMX2 resulted in decreased reporter-gene activity, demonstrating a direct regulatory impact. (F) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of ERK-phosphorylation, respectively, as shown by Western blot. (G) Treatment of EOL-1 cells with HTR7-inhibitor MMS and HTR7-activator LP211 resulted in decreased and increased levels of DLX2-transcription, respectively, as shown by RQ-PCR.

Article Snippet: The following primer sets were used: CD11B (Hs00167304_m1), DLX2 (Hs00207788_m1), EPX (Hs00946094_1), ELK1 (Hs00901847_m1), ETS1 (Hs00428293_m1), HMX2 (Hs01394375_m1), HMX3 (Hs1392772_m1), HTR7 (Hs04194798_s1), IL7R (Hs00902334_m1), IRF8 (Hs00175238_m1), KMT2A (Hs00610538_m1), PDGFRA (Hs00998018_m1), STAT5A (Hs00559638_m1), and TBP (Hs00427620_m1).

Techniques: Expressing, Binding Assay, Knockdown, Reporter Gene Assay, Activity Assay, Phospho-proteomics, Western Blot

This diagram summarizes the results of this study, showing a gene regulatory network. HMX2 and HMX3 are located centrally, activating and repressing factors and pathways are indicated above, and the target genes EPX and HTR7 below. Deregulation of EPX and HTR7 indicates aberrant effects for differentiation and proliferation. Genomic rearrangements targeting KMT2A or PDGFRA are indicated.

Journal: PLoS ONE

Article Title: Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia

doi: 10.1371/journal.pone.0240120

Figure Lengend Snippet: This diagram summarizes the results of this study, showing a gene regulatory network. HMX2 and HMX3 are located centrally, activating and repressing factors and pathways are indicated above, and the target genes EPX and HTR7 below. Deregulation of EPX and HTR7 indicates aberrant effects for differentiation and proliferation. Genomic rearrangements targeting KMT2A or PDGFRA are indicated.

Article Snippet: The following primer sets were used: CD11B (Hs00167304_m1), DLX2 (Hs00207788_m1), EPX (Hs00946094_1), ELK1 (Hs00901847_m1), ETS1 (Hs00428293_m1), HMX2 (Hs01394375_m1), HMX3 (Hs1392772_m1), HTR7 (Hs04194798_s1), IL7R (Hs00902334_m1), IRF8 (Hs00175238_m1), KMT2A (Hs00610538_m1), PDGFRA (Hs00998018_m1), STAT5A (Hs00559638_m1), and TBP (Hs00427620_m1).

Techniques: