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Image Search Results
Journal: Biomolecules
Article Title: Effects of GHR Deficiency and Juvenile Hypoglycemia on Immune Cells of a Porcine Model for Laron Syndrome.
doi: 10.3390/biom13040597
Figure Lengend Snippet: Figure 1. Lymphocyte populations, lymphocyte subpopulations and proliferative capacities of PBMC of WT and GHR-KO pigs. (A) Percentage of lymphocytes in the leukocytes of wild-type (WT) (black dots, n = 7) and growth hormone receptor knockout (GHR-KO) pigs (blue dots, n = 6). Lymphocyte percentages were not significantly different between WT and GHR-KO pigs. (B–I) Lymphocyte subpopulations of WT (black dots, n = 16) and GHR-KO pigs (blue dots, n = 15). Proportions of (B) CD79a+ B cells, (C) CD3+ T cells (D) CD8α+CD3−NK cells, (E) CD8α+CD3+ T cells, (F) SWC5+ γδ T cells, (G) CD4−CD8α+ lymphocytes, (H) CD4+CD8α+ activated/memory T cells did not significantly differ between WT and GHR-KO pigs. CD4+CD8α−cells (I) significantly differed between WT and GHR-KO pigs. (J–M) Proliferative capacity of peripheral blood mononuclear cells (PBMCs) of WT (black dots, n = 10) and GHR-KO pigs (blue dots, n = 10) after polyclonal stimulation with (J) pokeweed mitogen (PWM), (K) concanavalin A (ConA), (L) phytohaemagglutinin-L (PHA-L) and (M) M. paradisiaca lectin (BanLec) in vitro revealed similar proliferative capacity of WT and GHR-KO PBMCs. Data are shown as mean ± SD; ns = not significant, * p ≤0.05.
Article Snippet: Staining of 3 × 105 cells per well was performed with
Techniques: Knock-Out, In Vitro