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Image Search Results
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Article Title: Reparameterization of PAM50 expression identifies novel breast tumor dimensions and leads to discovery of a genomewide significant breast cancer locus at 12q15
doi: 10.1158/1055-9965.EPI-17-0887
Figure Lengend Snippet: Example Utah high-risk breast cancer pedigree 1817. a. Confirmed and sampled breast cancer cases are indicated in black (55 sampled out of 138 total confirmed UCR cases). Star, triangle and hexagon symbols indicate pedigree branches. b. shows only those cases from (a) with tumor expression data available and indicates PAM50 intrinsic subtype by color. Cases whose tumors are extreme for PC3 are indicated by ‘3’; extreme for PC5 are indicated by ‘5’. c. shows only the PC3-extreme cases from (b). A ‘+’ indicates those cases that share the genomewide significant region at 12q15.
Article Snippet: Gene expression data was generated using the
Techniques: Expressing
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Article Title: Reparameterization of PAM50 expression identifies novel breast tumor dimensions and leads to discovery of a genomewide significant breast cancer locus at 12q15
doi: 10.1158/1055-9965.EPI-17-0887
Figure Lengend Snippet: Summary of the 11 high-risk Utah pedigrees Tumor count by intrinsic subtype per pedigree.
Article Snippet: Gene expression data was generated using the
Techniques:
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Article Title: Reparameterization of PAM50 expression identifies novel breast tumor dimensions and leads to discovery of a genomewide significant breast cancer locus at 12q15
doi: 10.1158/1055-9965.EPI-17-0887
Figure Lengend Snippet: A slice from a three-dimensional scatterplot of PC1, PC2, and PC4 shows that they recapitulate the PAM50 intrinsic subtypes. Reinforcing the constrasts illustrated in Figure 2, PC1 here clearly distinguishes Basal-like from Luminal A tumors. PC2 and PC4 aid in distinguishing HER2-enriched from Luminal B tumors. Combined, these three components define clusters corresponding to the intrinsic subtypes.
Article Snippet: Gene expression data was generated using the
Techniques:
Journal: The Journal of comparative neurology
Article Title: Expression profile analysis of vulnerable CA1 pyramidal neurons in young-middle aged Ts65Dn mice
doi: 10.1002/cne.23663
Figure Lengend Snippet: Bar graphs and color coded heatmaps illustrating relative transcript levels in Ts65Dn (n = 9) and 2N (n = 7) mice at 4-9 months of age in CA1 neurons. (A) Several neurotrophins and cognate neurotrophin receptors displayed downregulation, including CNTF, NTF4/5, p75NTR, TrkA, TrkB, and TrkC (B) No significant changes in GluR subunits were observed. (C) Alterations in AD-related transcripts included SAA4, KCNIP3, MAPT4, and NPC2 (*p < 0.01), (**p < 0.005), and (*** p < 0.001) (t= trend 0.02< p < 0.05). Error bars indicate standard error of the mean (SEM).
Article Snippet: Taqman qPCR primers (
Techniques:
Journal: The Journal of comparative neurology
Article Title: Expression profile analysis of vulnerable CA1 pyramidal neurons in young-middle aged Ts65Dn mice
doi: 10.1002/cne.23663
Figure Lengend Snippet: (A) BDNF showed no difference in mRNA expression levels, however, the BDNF receptor TrkB (NTRK2) showed significant downregulation, in accordance with the microarray results. NTF3 showed a trend for downregulation and the NTF3 receptor TrkC (NTRK3) was significantly downregulated. ddCT was expressed as percent of 2N control for all qPCR results. Key, (* p < 0.05) and (t p < 0.1). Error bars indicate SEM.
Article Snippet: Taqman qPCR primers (
Techniques: Expressing, Microarray
Journal: The Journal of comparative neurology
Article Title: Expression profile analysis of vulnerable CA1 pyramidal neurons in young-middle aged Ts65Dn mice
doi: 10.1002/cne.23663
Figure Lengend Snippet: Immunoblot analysis using regional hippocampal dissections was performed to assess whether selected transcriptional alterations resulted in commensurate protein level changes in Ts65Dn mice compared to 2N littermates at 4-6 months of age. (A) Representative immunoblots for pro-BDNF, mature BDNF, NTF3, TrkB-FL, TrkB-T1, TrkC-FL, and TrkC-T1. β-tubulin (TUBB) expression was used as a loading control. (B) Normalized expression levels compared to TUBB expression show upregulation of pro-BDNF (p<0.02), a trend towards downregulation of TrkB-FL (p =0.09) and TrkC-T1 (p= 0.069), but no significant changes in NTF3, mature BDNF, TrkB-T1 and TrkC-FL expression. Key: 2N black, Ts65Dn grey.
Article Snippet: Taqman qPCR primers (
Techniques: Western Blot, Expressing