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Image Search Results
Journal: Toxicology Reports
Article Title: Characterization of marine-derived halogenated indoles as ligands of the aryl hydrocarbon receptor
doi: 10.1016/j.toxrep.2022.05.016
Figure Lengend Snippet: Antagonism of CYP1A1 catalytic activity induced by halogenated indoles. HepG2 cells were treated with 10 µM of the halogenated indoles for 24 h both alone and in combination with the AhR antagonist, GNF-351 (0.25 µM). CYP1A1 activity was determined via the EROD assay and is expressed as a percentage of the vehicle control (0.5% DMSO). Bars represent the mean ± SEM of three independent experiments performed in duplicate. Data were analyzed using a one-tailed t-test. *significantly decreased compared to the respective indole-only response, p < 0.05.
Article Snippet: 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD, 50 μg/mL in DMSO, >99.9%) was purchased from Cambridge Isotope Laboratories (Tewksbury, MA) and
Techniques: Activity Assay, One-tailed Test