gitr agonist Search Results


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GITR Inc agonistic anti-gitr mabs
Agonistic Anti Gitr Mabs, supplied by GITR Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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BioExpress anti-gitr mab (dta-1
Anti Gitr Mab (Dta 1, supplied by BioExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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BioExpress agonistic affinity-purified anti-gitr monoclonal antibody
Agonistic Affinity Purified Anti Gitr Monoclonal Antibody, supplied by BioExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Apogenix Inc a hexavalent gitr agonist
Screening of F8 antibody-cytokine fusion proteins featuring <t>wild-type</t> <t>GITRL</t> as immunomodulatory payload (a) Different formats of the F8 antibody such as diabody (Format 1 ), full IgG (Formats 2 and 4 ) or single-chain Fragment variable (scFv, Format 3 ) were fused to GITRL either as a single-chain trimer (Formats 1 and 2 ) or a monomer (Formats 3, 4 and 5 ) (b) the size exclusion profile for each variant was measured using a Superdex S200 10/300 increase column (c) binding to recombinant EDA was measured by surface plasmon resonance (d) binding to GITRL was measured by flow cytometry on CTLL-2 cells (e) the in vitro bioactivity was measured using a CTLL-2 reporter cell line that secretes luciferase in response to NF-κB activation via <t>GITR</t> agonism. Data represents mean ± SD.
A Hexavalent Gitr Agonist, supplied by Apogenix Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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GITR Inc humanized anti-gitr agonist monoclonal antibody
TNFR-targeted agents in development
Humanized Anti Gitr Agonist Monoclonal Antibody, supplied by GITR Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Promega agonistic anti-gitr antibodies
TNFR-targeted agents in development
Agonistic Anti Gitr Antibodies, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Leap Therapeutics anti-gitr agonist mab
An Overview of Clinical Trials in Gynecologic Cancer and/or Solid Cancer for Immune Target Agents
Anti Gitr Agonist Mab, supplied by Leap Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Corning Life Sciences gitr receptor agonist fusion protein
An Overview of Clinical Trials in Gynecologic Cancer and/or Solid Cancer for Immune Target Agents
Gitr Receptor Agonist Fusion Protein, supplied by Corning Life Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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MedImmune llc gitr agonist (e.g., fusion protein
An Overview of Clinical Trials in Gynecologic Cancer and/or Solid Cancer for Immune Target Agents
Gitr Agonist (E.G., Fusion Protein, supplied by MedImmune llc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Leap Therapeutics agonist antibody anti-gitr
An Overview of Clinical Trials in Gynecologic Cancer and/or Solid Cancer for Immune Target Agents
Agonist Antibody Anti Gitr, supplied by Leap Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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N/A
Anti-GITR recombinant human agonist antibody recognizing the GITRL binding region of human GITR. This antibody has not been tested for cross-reactivity with any other species.
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Image Search Results


Screening of F8 antibody-cytokine fusion proteins featuring wild-type GITRL as immunomodulatory payload (a) Different formats of the F8 antibody such as diabody (Format 1 ), full IgG (Formats 2 and 4 ) or single-chain Fragment variable (scFv, Format 3 ) were fused to GITRL either as a single-chain trimer (Formats 1 and 2 ) or a monomer (Formats 3, 4 and 5 ) (b) the size exclusion profile for each variant was measured using a Superdex S200 10/300 increase column (c) binding to recombinant EDA was measured by surface plasmon resonance (d) binding to GITRL was measured by flow cytometry on CTLL-2 cells (e) the in vitro bioactivity was measured using a CTLL-2 reporter cell line that secretes luciferase in response to NF-κB activation via GITR agonism. Data represents mean ± SD.

Journal: bioRxiv

Article Title: Engineering murine GITRL for antibody-mediated delivery to tumor-associated blood vessels

doi: 10.1101/2020.08.26.268375

Figure Lengend Snippet: Screening of F8 antibody-cytokine fusion proteins featuring wild-type GITRL as immunomodulatory payload (a) Different formats of the F8 antibody such as diabody (Format 1 ), full IgG (Formats 2 and 4 ) or single-chain Fragment variable (scFv, Format 3 ) were fused to GITRL either as a single-chain trimer (Formats 1 and 2 ) or a monomer (Formats 3, 4 and 5 ) (b) the size exclusion profile for each variant was measured using a Superdex S200 10/300 increase column (c) binding to recombinant EDA was measured by surface plasmon resonance (d) binding to GITRL was measured by flow cytometry on CTLL-2 cells (e) the in vitro bioactivity was measured using a CTLL-2 reporter cell line that secretes luciferase in response to NF-κB activation via GITR agonism. Data represents mean ± SD.

Article Snippet: Researchers at Apogenix have developed a fusion protein of a single-chain trimeric GITRL and an Fc portion yielding a hexavalent GITR agonist which showed superior in vitro agonistic activity compared to a clinical-grade agonistic antibody and showed some anti-tumor activity in preclinical models of cancer .

Techniques: Variant Assay, Binding Assay, Recombinant, SPR Assay, Flow Cytometry, In Vitro, Luciferase, Activation Assay

TNFR-targeted agents in development

Journal: Journal for Immunotherapy of Cancer

Article Title: Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy

doi: 10.1186/2051-1426-2-7

Figure Lengend Snippet: TNFR-targeted agents in development

Article Snippet: GITR , TRX518 , Humanized anti-GITR agonist monoclonal antibody , GITR, Inc. , I.

Techniques: Transduction, Recombinant

An Overview of Clinical Trials in Gynecologic Cancer and/or Solid Cancer for Immune Target Agents

Journal: OncoTargets and therapy

Article Title: Emerging Targets of Immunotherapy in Gynecologic Cancer

doi: 10.2147/OTT.S282530

Figure Lengend Snippet: An Overview of Clinical Trials in Gynecologic Cancer and/or Solid Cancer for Immune Target Agents

Article Snippet: , TRX518 , Anti-GITR agonist mAb , - , NCT02628574 , 1 , Solid Tumors , Active, not recruiting , Leap Therapeutics, Inc..

Techniques: Clinical Proteomics