Journal: Cell

Article Title: Data sanitization to reduce private information leakage from functional genomics

doi: 10.1016/j.cell.2020.09.036

Figure Lengend Snippet: Effect of functional genomics assay type on de-anonymization. See also Figure S2 and S3. (a) The linking scores and gap as a function of sequencing coverage for individual NA12878 for different functional genomics assays. (b) Linking score per base pair for each assay was calculated by normalizing the linking score values per subsampling by the total number of nucleotides in the sample. (c) Mean genotyping frequency per sequencing coverage for different assays. (d) The linking score and gap values from two individuals for ChIA-PET and ChIP-Seq experiments, (e) ChIP-Seq experiments, and (f) repli-Seq experiments. See also Figure S2.

Article Snippet: Another genotyping method popular for its low cost and portability is the Oxford Nanopore.

Techniques: Functional Assay, Sequencing, ChIA Pet Assay, ChIP-sequencing

Journal: Cell

Article Title: Data sanitization to reduce private information leakage from functional genomics

doi: 10.1016/j.cell.2020.09.036

Figure Lengend Snippet: Impact of sequencing depth on genotyping and linking accuracy. (a) The process of pooling reads from functional genomics data to generate different attacked databases. c amount of reads were pooled and a new cohort was generated. A linkage attack was performed for each new database using genomes as perfect information. (b) Variant calling was performed for pooled reads for each individual in the database. The panel shows the distribution of precision and sensitivity of the called genotypes over all individuals at different subsampling percentages using their genomes as the ground truth. (c) Cumulative linking accuracy before and after adding the false-positive genotypes. Linking accuracy was calculated as the ratio between the total number of correctly linked individuals.

Article Snippet: Another genotyping method popular for its low cost and portability is the Oxford Nanopore.

Techniques: Sequencing, Functional Assay, Generated, Variant Assay

Journal: Principles and Applications of Molecular Diagnostics

Article Title: Molecular Microbiology

doi: 10.1016/B978-0-12-816061-9.00005-9

Figure Lengend Snippet: Features of Food and Drug Administration–Cleared High-Risk Human Papillomavirus Tests

Article Snippet: A novel HCV genotyping method using a solid phase electrochemical array was developed by GenMark Diagnostics.

Techniques: Real-time Polymerase Chain Reaction, Amplification