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Selleck Chemicals
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Tokai Pharmaceuticals
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Innocrin Pharmaceuticals
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MultiTarget Pharmaceuticals
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Santa Cruz Biotechnology
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Tokai Pharmaceuticals
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Verlag GmbH
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Chemleader corporation
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MultiTarget Pharmaceuticals
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DIC Corporation
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Innovative Therapies
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InformationGaleterone (TOK-001) is a selectiveCYP17inhibitor andandrogen receptor (AR)antagonist withIC50of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.In vitroGaleterone is effective at preventing binding of [3H]-R1881
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Image Search Results
Journal: Scientific Reports
Article Title: Drivers of AR indifferent anti-androgen resistance in prostate cancer cells
doi: 10.1038/s41598-019-50220-1
Figure Lengend Snippet: ResA and ResB cells are resistant against modern anti-androgens and androgen deprivation. ( a ) Dose response curves showing the relative proliferation rate at increasing concentrations of the AR inhibitors enzalutamide (MDV3100), RD-162, apalutamide (ARN-509), darolutamide (ODM-201), and abiraterone acetate. All measurements are normalized to vehicle treated cells and set to 100. ( b ) Relative proliferation rate in normal growth medium (containing 10 µM enzalutamide for ResA/ResB) and in androgen deprived medium (dextran-coated charcoal treated serum, DCC). The shaded areas and error bars indicate the 95% confidence interval.
Article Snippet: G.A. is on the ICR list of rewards to inventors for
Techniques: