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Carestream Health
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Image Search Results
Journal: Nanotheranostics
Article Title: Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder
doi: 10.7150/ntno.95146
Figure Lengend Snippet: Treatment with cCPEm neither opens the blood-brain barrier nor augments FUS +MB -mediated dextran leakage. Representative image of whole brains of treated mice and quantification of the fluorescence intensity for 10 kDa ( A,B ) and 70 kDa dextran ( C,D ) using the Bruker In Vivo MS FX Pro optimal imaging system (IVIS). No significant fluorescence intensity was observed for mice treated with cCPEm and the sham group. Pre-treatment with cCPEm at 20 mg/kg 2.5 hours prior to FUS +MB treatment did not significantly increase leakage of FD10 and TAMRA-D70 compared to FUS +MB alone (n≥4, each bar dot representing the average fluorescence intensity (avg radiant efficiency) obtained from one brain hemisphere, mean ± SEM; Two-way ANOVA with Tukey's multiple comparisons tests, ns: not significant, ✱ p <0.05 , ✱✱ p<0.01 and ✱✱✱ p <0.001).
Article Snippet: The PBS-perfused mouse brains were then collected and immediately imaged in a
Techniques: Fluorescence, In Vivo, Imaging