Journal: Parasites & vectors

Article Title: Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.

doi: 10.1186/s13071-023-05899-7

Figure Lengend Snippet: Fig. 1 Average mortality after contact exposure to fluralaner at concentrations of 0–100 mg/ml for Culicoides sonorensis at 1 h (n = 777 total individuals tested) and 24 h (n = 773 total individuals tested); 1 h is represented by light blue and 24 h by dark blue. Error bars represent standard deviation and asterisks represent significant differences between control (concentration = 0 mg/ml) and treatment at each concentration (***P < 0.0005). Concentrations not marked with asterisks did not differ significantly between control and treatment

Article Snippet: Selleckchem: Fluralaner safety data sheet.

Techniques: Standard Deviation, Control, Concentration Assay

Journal: Parasites & vectors

Article Title: Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.

doi: 10.1186/s13071-023-05899-7

Figure Lengend Snippet: Fig. 2 Average mortality after topical exposure to fluralaner at concentrations of 0–10 mg/ml for Culicoides sonorensis at 1 h (n = 480 total individuals tested) and 24 h (n = 475 total individuals tested); 1 h is represented by light blue and 24 h by dark blue. Error bars represent standard deviation, and asterisks represent significant differences between control (concentration = 0 mg/ml) and treatment at each concentration (***P < 0.0005). Concentrations not marked with asterisks did not differ significantly between control and treatment

Article Snippet: Selleckchem: Fluralaner safety data sheet.

Techniques: Standard Deviation, Control, Concentration Assay

Journal: Parasites & vectors

Article Title: Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.

doi: 10.1186/s13071-023-05899-7

Figure Lengend Snippet: Fig. 3 Average mortality after oral exposure to fluralaner at concentrations of 0–1000 ng/ml for Culicoides sonorensis at 1 h (n = 144 total individuals tested) and 24 h (n = 144 total individuals tested); 1 h is represented by light blue and 24 h by dark blue. Error bars represent standard deviation and asterisks represent significant differences between control (concentration = 0 ng/ml) and treatment at each concentration (***P < 0.0005). Concentrations not marked with asterisks did not differ significantly between control and treatment

Article Snippet: Selleckchem: Fluralaner safety data sheet.

Techniques: Standard Deviation, Control, Concentration Assay

Journal: Current Research in Parasitology & Vector-borne Diseases

Article Title: Protecting dogs and cats against the Australian paralysis tick, Ixodes holocyclus (Acari: Ixodidae): A review of the Australian acaricide registration process

doi: 10.1016/j.crpvbd.2021.100054

Figure Lengend Snippet: Systemically distributed acaricides that have a label claim for the control of Ixodes holocyclus in dogs and cats. Doses shown are for medium size dogs (10–20 kg) and cats (2.6–5.0 kg). (Source: APVMA – Public Chemical Registration Information System Search; Access date: August 23, 2020).

Article Snippet: Bravecto® Spot-on solution , 280 mg/ml Fluralaner , Cats , Treatment and control for 3 months , Intervet.

Techniques: Control

Journal: Parasites & Vectors

Article Title: A randomized, blinded, controlled, multi-centered field study assessing the treatment of gastrointestinal nematode infections in cats with fluralaner plus moxidectin spot-on solution (Bravecto® Plus)

doi: 10.1186/s13071-018-3169-x

Figure Lengend Snippet: Geometric (arithmetic) mean faecal egg counts and percent reduction (per protocol population)

Article Snippet: In this study, the nematode control provided by a single application of fluralaner plus moxidectin was compared with that provided by a single application of emodepside plus praziquantel (Profender®, Bayer Animal Health).

Techniques:

Journal: Parasites & Vectors

Article Title: A randomized, blinded, controlled, multi-centered field study assessing the treatment of gastrointestinal nematode infections in cats with fluralaner plus moxidectin spot-on solution (Bravecto® Plus)

doi: 10.1186/s13071-018-3169-x

Figure Lengend Snippet: Number of cats with positive faecal egg counts and, for the fluralaner-moxidectin group, comparison of pre- and post-treatment faecal egg counts, per protocol population

Article Snippet: In this study, the nematode control provided by a single application of fluralaner plus moxidectin was compared with that provided by a single application of emodepside plus praziquantel (Profender®, Bayer Animal Health).

Techniques: Comparison

Journal: Parasites & Vectors

Article Title: A randomized, blinded, controlled, multi-centered field study assessing the treatment of gastrointestinal nematode infections in cats with fluralaner plus moxidectin spot-on solution (Bravecto® Plus)

doi: 10.1186/s13071-018-3169-x

Figure Lengend Snippet: Percent of nematode free cats, with non-inferiority analysis at the post-treatment assessment (per protocol population)

Article Snippet: In this study, the nematode control provided by a single application of fluralaner plus moxidectin was compared with that provided by a single application of emodepside plus praziquantel (Profender®, Bayer Animal Health).

Techniques:

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Chemical structures of fipronil and fluralaner.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques:

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Larval bioassays of fluralaner on fourth-instar Ae. aegypti and An. gambiae larvae.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques: Bioassay, Saline

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Topical bioassays of fluralaner on Ae. aegypti and An. gambiae adult females.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques:

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Bioassays of fluralaner and fipronil on Ae. aegypti adult females.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques: Bioassay, Injection

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Effects of synergists in feeding assays of fluralaner against Ae. aegypti adult females.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques:

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Effects of synergists in topical assays of fluralaner against Ae. aegypti adult females.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques:

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Glass contact and feeding bioassays of fluralaner against susceptible and resistant adult D. melanogaster strains.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques:

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Electrophysiological recordings on intact or severed CS-OR D. melanogaster larval CNS. ( A ) Intact CNS treated with 10 µM fluralaner; ( B ) Severed CNS treated with 10 µM fluralaner; ( C ) Intact CNS treated with 10 µM fipronil; ( D ) Severed CNS treated with 10 µM fipronil.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques:

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Electrophysiological recordings on CS-OR or rdl -1675 D. melanogaster intact larval CNS. ( A ) CS-OR CNS treated with 10 µM fluralaner; ( B ) rdl -1675 CNS treated with 10 µM fluralaner; ( C ) CS-OR CNS treated with 1 µM fluralaner; ( D ) rdl -1675 CNS treated with 1 µM fluralaner; ( E ) CS-OR CNS treated with 0.1 µM fluralaner; ( F ) rdl -1675 CNS treated with 0.1 µM fluralaner.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques:

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Electrophysiological recordings on severed D. melanogaster larval CNS, with GABA inhibition. Test compounds were added after 5-min incubation with 1 mM GABA. ( A ) CS-OR CNS treated with 10 µM dieldrin; ( B ) rdl -1675 CNS treated with 10 µM dieldrin; ( C ) CS-OR CNS treated with 3 µM fluralaner; ( D ) rdl -1675 CNS treated with 3 µM fluralaner; ( E ) CS-OR CNS treated with 10 µM fipronil; ( F ) rdl -1675 CNS treated with 10 µM fipronil.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques: Inhibition, Incubation

Journal: International Journal of Environmental Research and Public Health

Article Title: Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

doi: 10.3390/ijerph14020154

Figure Lengend Snippet: Concentration response curve (% responding preparations) of fluralaner on resistant and susceptible strains of D. melanogaster , in transected larval CNS recordings. Fluralaner was added after a 5-min incubation of 1 mM GABA to inhibit nerve activity. Solid line and dotted line represent curves for rdl -1675 and CS-OR preparations, respectively.

Article Snippet: Effects of fluralaner, fipronil, dieldrin, and picrotoxin were tested on GABA α 1 β 3 γ 2 ion channels expressed in HEK293 cells by ChanTest Corporation, Cleveland, OH, USA.

Techniques: Concentration Assay, Incubation, Activity Assay