fluorogenic substrate Search Results


cathepsin b l  (R&D Systems)
93
R&D Systems cathepsin b l
Cathepsin B L, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fluorogenic hdac substrates  (BPS Bioscience)
93
BPS Bioscience fluorogenic hdac substrates
Fluorogenic Hdac Substrates, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fluorogenic peptide substrate  (R&D Systems)
93
R&D Systems fluorogenic peptide substrate
Fluorogenic Peptide Substrate, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fluorogenic mmp activity assay  (R&D Systems)
93
R&D Systems fluorogenic mmp activity assay
99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and <t>MMP</t> <t>activity</t> quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.
Fluorogenic Mmp Activity Assay, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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sirt5  (BPS Bioscience)
91
BPS Bioscience sirt5
99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and <t>MMP</t> <t>activity</t> quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.
Sirt5, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hdac substrate 3  (BPS Bioscience)
93
BPS Bioscience hdac substrate 3
99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and <t>MMP</t> <t>activity</t> quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.
Hdac Substrate 3, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mca lys pro leu gly leu dpa ala arg nh2  (R&D Systems)
99
R&D Systems mca lys pro leu gly leu dpa ala arg nh2
99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and <t>MMP</t> <t>activity</t> quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.
Mca Lys Pro Leu Gly Leu Dpa Ala Arg Nh2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mca plgl dpa ar nh2 fluorogenic mmp substrate  (R&D Systems)
99
R&D Systems mca plgl dpa ar nh2 fluorogenic mmp substrate
99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and <t>MMP</t> <t>activity</t> quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.
Mca Plgl Dpa Ar Nh2 Fluorogenic Mmp Substrate, supplied by R&D Systems, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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boc v p r amc fluorogenic peptide substrate  (R&D Systems)
93
R&D Systems boc v p r amc fluorogenic peptide substrate
99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and <t>MMP</t> <t>activity</t> quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.
Boc V P R Amc Fluorogenic Peptide Substrate, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mca sevnldaefrk dnp rr nh2 fluorogenic peptide substrate  (R&D Systems)
92
R&D Systems mca sevnldaefrk dnp rr nh2 fluorogenic peptide substrate
99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and <t>MMP</t> <t>activity</t> quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.
Mca Sevnldaefrk Dnp Rr Nh2 Fluorogenic Peptide Substrate, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fluorogenic hdac substrate class 2a  (BPS Bioscience)
93
BPS Bioscience fluorogenic hdac substrate class 2a
99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and <t>MMP</t> <t>activity</t> quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.
Fluorogenic Hdac Substrate Class 2a, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and MMP activity quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.

Journal: Journal of Nuclear Medicine

Article Title: Preclinical Evaluation of RYM1, a Matrix Metalloproteinase–Targeted Tracer for Imaging Aneurysm

doi: 10.2967/jnumed.116.188656

Figure Lengend Snippet: 99mTc-RYM1 imaging of AAA. (A and B) Examples of fused 99mTc-RYM1 SPECT/CT images of animals from the low remodeling (A) and aneurysm (B) groups, classified on the basis of visual in situ analysis of abdominal aorta. Transversal (left), coronal (middle), and sagittal (right) views are shown. Arrows point to areas of maximal tracer uptake in abdominal aorta. (C) Quantification of 99mTc-RYM1 signal in area of maximal tracer uptake in suprarenal abdominal aorta in low remodeling and AAA groups. *P < 0.05. (D) Correlation between 99mTc-RYM1 signal in vivo and MMP activity quantified by zymography ex vivo. AU = arbitrary units; cpv = counts per voxel; LR = low remodeling.

Article Snippet: RYM1 inhibition constants (K i ) for recombinant human MMP-2, -7, -9, -12, and -13 (R&D Systems) were evaluated in vitro using a fluorogenic MMP activity assay based on Mca-KPLGL-Dpa-AR-NH2 fluorogenic peptide substrate (R&D Systems), as previously described with minor modifications ( 8 ).

Techniques: Imaging, Single Photon Emission Computed Tomography, In Situ, In Vivo, Activity Assay, Zymography, Ex Vivo

Ex vivo characterization of suprarenal abdominal aorta. (A) Maximal external diameter of abdominal aorta in low remodeling and AAA groups. (B) Aortic MMP activity quantified by zymography in low remodeling and AAA groups. **P < 0.01. AU = arbitrary units; LR = low remodeling.

Journal: Journal of Nuclear Medicine

Article Title: Preclinical Evaluation of RYM1, a Matrix Metalloproteinase–Targeted Tracer for Imaging Aneurysm

doi: 10.2967/jnumed.116.188656

Figure Lengend Snippet: Ex vivo characterization of suprarenal abdominal aorta. (A) Maximal external diameter of abdominal aorta in low remodeling and AAA groups. (B) Aortic MMP activity quantified by zymography in low remodeling and AAA groups. **P < 0.01. AU = arbitrary units; LR = low remodeling.

Article Snippet: RYM1 inhibition constants (K i ) for recombinant human MMP-2, -7, -9, -12, and -13 (R&D Systems) were evaluated in vitro using a fluorogenic MMP activity assay based on Mca-KPLGL-Dpa-AR-NH2 fluorogenic peptide substrate (R&D Systems), as previously described with minor modifications ( 8 ).

Techniques: Ex Vivo, Activity Assay, Zymography