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Image Search Results
Journal: Blood Cancer Journal
Article Title: The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia
doi: 10.1038/bcj.2012.28
Figure Lengend Snippet: ( a – c ) Molecular structure of AKN-028 ( a ). Inhibition of FLT3, CLK and RPS6 kinases in the kinase-panel screen after exposure to 1 μℳ of AKN-028, AC220 and staurosporine ( b ). displays the inhibitory activity on FLT3 enzyme of AKN-028 and sunitinib outlined as dose–response curves from a typical experiment in the FLT3 enzyme-inhibition assay.
Article Snippet: The inhibitory effects were verified by full dose–response curves on the following kinases: FLT3 (IMAP), CDC-like kinase 1,
Techniques: Inhibition, Activity Assay, Enzyme Inhibition Assay