Journal: Journal of analytical toxicology

Article Title: Identification of Unique Metabolites of the Designer Opioid Furanyl Fentanyl.

doi: 10.1093/jat/bkx022

Figure Lengend Snippet: Figure 1. Furanyl fentanyl and proposed metabolite structures.

Article Snippet: Materials and Methods Chemicals and reagents Reference materials of furanyl fentanyl, furanyl norfentanyl and 4-anilino-N-phenethyl-piperidine (4-ANPP) were procured from Cayman Chemical Co. (Ann Arbor, MI).

Techniques:

Journal: Journal of analytical toxicology

Article Title: Identification of Unique Metabolites of the Designer Opioid Furanyl Fentanyl.

doi: 10.1093/jat/bkx022

Figure Lengend Snippet: Figure 3. Furanyl fentanyl proposed metabolite structures.

Article Snippet: Materials and Methods Chemicals and reagents Reference materials of furanyl fentanyl, furanyl norfentanyl and 4-anilino-N-phenethyl-piperidine (4-ANPP) were procured from Cayman Chemical Co. (Ann Arbor, MI).

Techniques:

Journal: Psychopharmacology

Article Title: Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats

doi: 10.1007/s00213-021-05981-x

Figure Lengend Snippet: Chemical structures and mass to charge ratios ( m/z ) of cyclopropylfentanyl and cyclopropylnorfentanyl

Article Snippet: Cyclopropylfentanyl hydrochloride for animal experiments was acquired from Cayman Chemical (Ann Arbor, MI, USA).

Techniques:

Journal: Psychopharmacology

Article Title: Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats

doi: 10.1007/s00213-021-05981-x

Figure Lengend Snippet: MRM chromatograms of a rat plasma sample obtained 4 h after injection of 300 µg/kg cyclopropylfentanyl analyzed with the presented UHPLC-MS/MS method. Abbreviations: CPF , cyclopropylfentanyl; CPNF , cyclopropylnorfentanyl

Article Snippet: Cyclopropylfentanyl hydrochloride for animal experiments was acquired from Cayman Chemical (Ann Arbor, MI, USA).

Techniques: Clinical Proteomics, Injection, Tandem Mass Spectroscopy

Journal: Psychopharmacology

Article Title: Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats

doi: 10.1007/s00213-021-05981-x

Figure Lengend Snippet: Stability data for cyclopropylfentanyl and cyclopropylnorfentanyl in extracted samples stored at 10 °C and in plasma stored at − 80 °C

Article Snippet: Cyclopropylfentanyl hydrochloride for animal experiments was acquired from Cayman Chemical (Ann Arbor, MI, USA).

Techniques: Clinical Proteomics, Concentration Assay

Journal: Psychopharmacology

Article Title: Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats

doi: 10.1007/s00213-021-05981-x

Figure Lengend Snippet: Time-course of pharmacodynamic effects induced by s.c. cyclopropylfentanyl administration (30, 100, and 300 µg/kg) in male rats. Body temperature, catalepsy score, and hot plate latency were measured at 0, 15, 30, 60, 120, 240, and 480 min after injection. Control animals received s.c. saline vehicle (1 mL/kg). Data are expressed as the mean ± SEM for N = 6 rats/group. Filled symbols represent significant differences when compared to saline-treated animals at a given time point (Tukey’s multiple comparison test, p < 0.05)

Article Snippet: Cyclopropylfentanyl hydrochloride for animal experiments was acquired from Cayman Chemical (Ann Arbor, MI, USA).

Techniques: Injection, Control, Saline, Comparison

Journal: Psychopharmacology

Article Title: Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats

doi: 10.1007/s00213-021-05981-x

Figure Lengend Snippet: Pharmacokinetic constants for cyclopropylfentanyl and cyclopropylnorfentanyl after s.c. administration of 30, 100, or 300 µg/kg cyclopropylfentanyl in male rats

Article Snippet: Cyclopropylfentanyl hydrochloride for animal experiments was acquired from Cayman Chemical (Ann Arbor, MI, USA).

Techniques:

Journal: Psychopharmacology

Article Title: Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats

doi: 10.1007/s00213-021-05981-x

Figure Lengend Snippet: Comparison of observed versus predicted area-under-the-curve ( AUC ) values for cyclopropylfentanyl after s.c. administration of 30, 100, or 300 µg/kg cyclopropylfentanyl in rats. Observed AUC values were obtained from time-concentration profiles depicted in Fig. , whereas predicted values at 100 and 300 μg/kg doses were calculated by multiplying the observed AUC values at 30 μg/kg by 3.33 and 10, respectively. Data are expressed as the mean ± SEM for N = 6 rats/group

Article Snippet: Cyclopropylfentanyl hydrochloride for animal experiments was acquired from Cayman Chemical (Ann Arbor, MI, USA).

Techniques: Comparison, Concentration Assay

Journal: Psychopharmacology

Article Title: Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats

doi: 10.1007/s00213-021-05981-x

Figure Lengend Snippet: Concentration–time profiles for cyclopropylfentanyl and cyclopropylnorfentanyl in rats after s.c. administration of 30, 100, or 300 µg/kg cyclopropylfentanyl. Rats fitted with indwelling jugular catheters received cyclopropylfentanyl at time zero. Blood samples were withdrawn via the catheters immediately prior to and 15, 30, 60, 120, 240, and 480 min after cyclopropylfentanyl injection. Plasma samples were assayed for analytes using UHPLC-MS/MS. Data are expressed as the mean ± SEM for N = 6 rats/group. Filled symbols represent significant differences when compared to the low-dose group (30 µg/kg) at a given time point (Tukey’s multiple comparison test, p < 0.05)

Article Snippet: Cyclopropylfentanyl hydrochloride for animal experiments was acquired from Cayman Chemical (Ann Arbor, MI, USA).

Techniques: Concentration Assay, Injection, Clinical Proteomics, Tandem Mass Spectroscopy, Comparison

Journal: Psychopharmacology

Article Title: Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats

doi: 10.1007/s00213-021-05981-x

Figure Lengend Snippet: Correlations between AUC values for cyclopropylfentanyl versus body temperatures, catalepsy scores, and hot plate latency. Raw data from Figs. and were used to construct the correlation matrices which plot mean temperature, summed catalepsy scores, and mean hot plate latency for each rat versus corresponding AUC values for cyclopropylfentanyl in the same subjects over the 8-h session. Pearson’s r and p values are shown

Article Snippet: Cyclopropylfentanyl hydrochloride for animal experiments was acquired from Cayman Chemical (Ann Arbor, MI, USA).

Techniques: Construct