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Image Search Results
Journal: Drug Delivery
Article Title: Enhanced oral bioavailability of koumine by complexation with hydroxypropyl-β-cyclodextrin: preparation, optimization, ex vivo and in vivo characterization
doi: 10.1080/10717544.2021.1998248
Figure Lengend Snippet: Caco-2 permeability study. (A) Schematic diagram of Caco-2 cell monolayers. (B) Cytotoxicity of KME and KME/HP-β-CD inclusion complexes in Caco-2 cells. Cells were incubated with KME or KME/HP-β-CD at 5–100 μg/mL for 24 h and evaluated by CCK-8 assay. Values are means ± SD ( n = 6). (C) Transepithelial electrical resistance (TEER) of Caco-2 cell monolayers was measured by a Millicell-ERS epithelial voltmeter from day 0 to day 21. (D) The transport amount of KME and KME/HP-β-CD across Caco-2 cells monolayers in 120 min. Data are shown as mean ± SD ( n = 3). * p < .05, ** p < .01, compared to the KME group.
Article Snippet: At the end of 21 days, a
Techniques: Permeability, Incubation, CCK-8 Assay