encode deep sequencing data Search Results


deep-sequencing data  (SciClone Inc)
90
SciClone Inc deep-sequencing data
Deep Sequencing Data, supplied by SciClone Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/deep-sequencing data/product/SciClone Inc
Average 90 stars, based on 1 article reviews
deep-sequencing data - by Bioz Stars, 2026-05
90/100 stars
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deep sequencing data set  (Temasek Laboratories)
90
Temasek Laboratories deep sequencing data set
Deep Sequencing Data Set, supplied by Temasek Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/deep sequencing data set/product/Temasek Laboratories
Average 90 stars, based on 1 article reviews
deep sequencing data set - by Bioz Stars, 2026-05
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sequencing data  (Bioprofile Testing)
86
Bioprofile Testing sequencing data
Activation of HTR2B promotes STAT1 protein expression in osteosarcoma cell lines. A) Transcriptome <t>sequencing</t> analysis showed that HTR2B and STAT1 genes were significantly upregulated in HTR2B overexpression group. B) The protein–protein interaction analysis suggested STAT1 may be potential downstream target of HTR2B activation. (C) HDOCK Server analysis showed that HTR2B and STAT1 can be stable binding. D) Western blot analysis demonstrated that HTR2B activation by lentivirus or BW‐723C86 increased STAT1 protein expression. E) Representative images of STAT1 lentivirus transfection in K7M2 cell and mRNA and protein expression of STAT1 were significantly decreased. F) The mRNA and protein expression of STAT1 were significantly decreased in STAT1 lentivirus transfection in LM8 cell. * P < 0.05, ** P < 0.01.
Sequencing Data, supplied by Bioprofile Testing, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sequencing data/product/Bioprofile Testing
Average 86 stars, based on 1 article reviews
sequencing data - by Bioz Stars, 2026-05
86/100 stars
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Image Search Results


Activation of HTR2B promotes STAT1 protein expression in osteosarcoma cell lines. A) Transcriptome sequencing analysis showed that HTR2B and STAT1 genes were significantly upregulated in HTR2B overexpression group. B) The protein–protein interaction analysis suggested STAT1 may be potential downstream target of HTR2B activation. (C) HDOCK Server analysis showed that HTR2B and STAT1 can be stable binding. D) Western blot analysis demonstrated that HTR2B activation by lentivirus or BW‐723C86 increased STAT1 protein expression. E) Representative images of STAT1 lentivirus transfection in K7M2 cell and mRNA and protein expression of STAT1 were significantly decreased. F) The mRNA and protein expression of STAT1 were significantly decreased in STAT1 lentivirus transfection in LM8 cell. * P < 0.05, ** P < 0.01.

Journal: Advanced Science

Article Title: Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1‐NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity

doi: 10.1002/advs.202415276

Figure Lengend Snippet: Activation of HTR2B promotes STAT1 protein expression in osteosarcoma cell lines. A) Transcriptome sequencing analysis showed that HTR2B and STAT1 genes were significantly upregulated in HTR2B overexpression group. B) The protein–protein interaction analysis suggested STAT1 may be potential downstream target of HTR2B activation. (C) HDOCK Server analysis showed that HTR2B and STAT1 can be stable binding. D) Western blot analysis demonstrated that HTR2B activation by lentivirus or BW‐723C86 increased STAT1 protein expression. E) Representative images of STAT1 lentivirus transfection in K7M2 cell and mRNA and protein expression of STAT1 were significantly decreased. F) The mRNA and protein expression of STAT1 were significantly decreased in STAT1 lentivirus transfection in LM8 cell. * P < 0.05, ** P < 0.01.

Article Snippet: Sequencing data were analyzed with the assistance of Bioprofile (Shanghai, China).

Techniques: Activation Assay, Expressing, Sequencing, Over Expression, Binding Assay, Western Blot, Transfection

Activation of HTR2B suppresses osteosarcoma progression via NLRP3 inflammasome pathway. A) KEGG enrichment analysis of transcriptome sequencing showed that the NOD‐like receptor signaling pathway is enriched, which containing the STAT1. B) Western blot analysis showed that promotion of HTR2B protein by lentivirus or BW‐723C86, knockdown of STAT1, and HTR2B overexpression combined with STAT1 knockdown led to the activation of the NLRP3 inflammasome pathway.

Journal: Advanced Science

Article Title: Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1‐NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity

doi: 10.1002/advs.202415276

Figure Lengend Snippet: Activation of HTR2B suppresses osteosarcoma progression via NLRP3 inflammasome pathway. A) KEGG enrichment analysis of transcriptome sequencing showed that the NOD‐like receptor signaling pathway is enriched, which containing the STAT1. B) Western blot analysis showed that promotion of HTR2B protein by lentivirus or BW‐723C86, knockdown of STAT1, and HTR2B overexpression combined with STAT1 knockdown led to the activation of the NLRP3 inflammasome pathway.

Article Snippet: Sequencing data were analyzed with the assistance of Bioprofile (Shanghai, China).

Techniques: Activation Assay, Sequencing, Western Blot, Knockdown, Over Expression

HTR2B activation and its impact on the tumor immune microenvironment. A) The GO‐GSEA analysis of tumor tissue transcriptome sequencing revealed that HTR2B activation associated with multiple immune reaction processes. B) The KEGG‐GSEA analysis of tumor tissue transcriptome sequencing found that activation of HTR2B associated with multiple immune reaction processes. C) The analysis of osteosarcoma single‐cell database revealed the enrichment of HTR2B in macrophage. D) The microenvironment scoring of HTR2B expression. E) Bioinformatics analysis of GSE19276 and TARGET‐Osteosarcoma databases showed that high HTR2B expression correlates with increased immune cell infiltration, containing macrophage. * P < 0.05, ** P < 0.01.

Journal: Advanced Science

Article Title: Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1‐NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity

doi: 10.1002/advs.202415276

Figure Lengend Snippet: HTR2B activation and its impact on the tumor immune microenvironment. A) The GO‐GSEA analysis of tumor tissue transcriptome sequencing revealed that HTR2B activation associated with multiple immune reaction processes. B) The KEGG‐GSEA analysis of tumor tissue transcriptome sequencing found that activation of HTR2B associated with multiple immune reaction processes. C) The analysis of osteosarcoma single‐cell database revealed the enrichment of HTR2B in macrophage. D) The microenvironment scoring of HTR2B expression. E) Bioinformatics analysis of GSE19276 and TARGET‐Osteosarcoma databases showed that high HTR2B expression correlates with increased immune cell infiltration, containing macrophage. * P < 0.05, ** P < 0.01.

Article Snippet: Sequencing data were analyzed with the assistance of Bioprofile (Shanghai, China).

Techniques: Activation Assay, Sequencing, Expressing

Single‐cell sequencing results and marker enrichment. A) Unsupervised clustering analysis identified 6 distinct cells into Osteoblasts, T cells, B cells, NK cells, Macrophages, and DC clusters, respectively. B) The distribution and percentage of each subgroups in NC and OE group; C) The markers heatmap of different clusters in single cell. D) The representative genes enriched in T cells, B cells, NK cells, Macrophages, DC clusters, respectively.

Journal: Advanced Science

Article Title: Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1‐NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity

doi: 10.1002/advs.202415276

Figure Lengend Snippet: Single‐cell sequencing results and marker enrichment. A) Unsupervised clustering analysis identified 6 distinct cells into Osteoblasts, T cells, B cells, NK cells, Macrophages, and DC clusters, respectively. B) The distribution and percentage of each subgroups in NC and OE group; C) The markers heatmap of different clusters in single cell. D) The representative genes enriched in T cells, B cells, NK cells, Macrophages, DC clusters, respectively.

Article Snippet: Sequencing data were analyzed with the assistance of Bioprofile (Shanghai, China).

Techniques: Sequencing, Marker