emc4 Search Results


gene exp emc4 hs00212821 m1  (Thermo Fisher)
86
Thermo Fisher gene exp emc4 hs00212821 m1
Gene Exp Emc4 Hs00212821 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
gene exp emc4 hs00212821 m1 - by Bioz Stars, 2026-03
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antibody emc4  (Bethyl)
90
Bethyl antibody emc4
Antibody Emc4, supplied by Bethyl, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
antibody emc4 - by Bioz Stars, 2026-03
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emc4  (Proteintech)
91
Proteintech emc4
(A) Topology of the nine-subunit human EMC. In mammals, the EMC is composed of seven membrane-spanning and two soluble subunits. The central insertase is composed of the two central subunits EMC3 (a homolog of YidC and member of the Oxa1 superfamily of insertases) and EMC6 ( ; ; ). In both yeast and humans, the EMC also contains a globular cytosolic domain (scaffolded around EMC2 and in mammals containing the redundant paralogs EMC8 or 9) and a large lumenal domain (composed of EMC1, 7, 10, and a single β-strand of <t>EMC4).</t> The function of the lumenal domain of the EMC is not known, but β -propellers, like those conserved in EMC1, are typically considered protein-protein interaction motifs. (B) Topology of the heterotrimeric BOS complex. NOMO contains 12 lumenal IgG repeats and a single C-terminal TMD. The single-spanning protein NCLN also has a large lumenal domain, and is homologous to nicastrin, a component of the γ-secretase complex . Finally, TMEM147 contains 7 TMDs and is homologous to APH-1 in the γ-secretase complex . (C) Flow cytometry analysis of the ratiometric ADRA1A protein reporter with or without the N-terminal fusion of the signal sequence (ss) of Pre-Prolactin followed by T4 Lysozyme (T4L), as described in . (D) Flow cytometry analysis of the ratiometric AGTR2 protein reporter with or without an N-terminal fusion of the first TMD of MAN1A1, a membrane protein of N cyt topology. Note that both the N-terminal fusion of MAN1A1 and of (ss)-T4 lysozyme behave similarly and rescue the NOMO kd and EMC5 kd phenotypes.
Emc4, supplied by Proteintech, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/emc4/product/Proteintech
Average 91 stars, based on 1 article reviews
emc4 - by Bioz Stars, 2026-03
91/100 stars
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mim-emerald cdna  (GenScript corporation)
90
GenScript corporation mim-emerald cdna
(A) Topology of the nine-subunit human EMC. In mammals, the EMC is composed of seven membrane-spanning and two soluble subunits. The central insertase is composed of the two central subunits EMC3 (a homolog of YidC and member of the Oxa1 superfamily of insertases) and EMC6 ( ; ; ). In both yeast and humans, the EMC also contains a globular cytosolic domain (scaffolded around EMC2 and in mammals containing the redundant paralogs EMC8 or 9) and a large lumenal domain (composed of EMC1, 7, 10, and a single β-strand of <t>EMC4).</t> The function of the lumenal domain of the EMC is not known, but β -propellers, like those conserved in EMC1, are typically considered protein-protein interaction motifs. (B) Topology of the heterotrimeric BOS complex. NOMO contains 12 lumenal IgG repeats and a single C-terminal TMD. The single-spanning protein NCLN also has a large lumenal domain, and is homologous to nicastrin, a component of the γ-secretase complex . Finally, TMEM147 contains 7 TMDs and is homologous to APH-1 in the γ-secretase complex . (C) Flow cytometry analysis of the ratiometric ADRA1A protein reporter with or without the N-terminal fusion of the signal sequence (ss) of Pre-Prolactin followed by T4 Lysozyme (T4L), as described in . (D) Flow cytometry analysis of the ratiometric AGTR2 protein reporter with or without an N-terminal fusion of the first TMD of MAN1A1, a membrane protein of N cyt topology. Note that both the N-terminal fusion of MAN1A1 and of (ss)-T4 lysozyme behave similarly and rescue the NOMO kd and EMC5 kd phenotypes.
Mim Emerald Cdna, supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mim-emerald cdna/product/GenScript corporation
Average 90 stars, based on 1 article reviews
mim-emerald cdna - by Bioz Stars, 2026-03
90/100 stars
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rabbit polyclonal emc4 antibody (catalog #: ap14717a)  (WuXi AppTec)
90
WuXi AppTec rabbit polyclonal emc4 antibody (catalog #: ap14717a)
(A) Topology of the nine-subunit human EMC. In mammals, the EMC is composed of seven membrane-spanning and two soluble subunits. The central insertase is composed of the two central subunits EMC3 (a homolog of YidC and member of the Oxa1 superfamily of insertases) and EMC6 ( ; ; ). In both yeast and humans, the EMC also contains a globular cytosolic domain (scaffolded around EMC2 and in mammals containing the redundant paralogs EMC8 or 9) and a large lumenal domain (composed of EMC1, 7, 10, and a single β-strand of <t>EMC4).</t> The function of the lumenal domain of the EMC is not known, but β -propellers, like those conserved in EMC1, are typically considered protein-protein interaction motifs. (B) Topology of the heterotrimeric BOS complex. NOMO contains 12 lumenal IgG repeats and a single C-terminal TMD. The single-spanning protein NCLN also has a large lumenal domain, and is homologous to nicastrin, a component of the γ-secretase complex . Finally, TMEM147 contains 7 TMDs and is homologous to APH-1 in the γ-secretase complex . (C) Flow cytometry analysis of the ratiometric ADRA1A protein reporter with or without the N-terminal fusion of the signal sequence (ss) of Pre-Prolactin followed by T4 Lysozyme (T4L), as described in . (D) Flow cytometry analysis of the ratiometric AGTR2 protein reporter with or without an N-terminal fusion of the first TMD of MAN1A1, a membrane protein of N cyt topology. Note that both the N-terminal fusion of MAN1A1 and of (ss)-T4 lysozyme behave similarly and rescue the NOMO kd and EMC5 kd phenotypes.
Rabbit Polyclonal Emc4 Antibody (Catalog #: Ap14717a), supplied by WuXi AppTec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit polyclonal emc4 antibody (catalog #: ap14717a)/product/WuXi AppTec
Average 90 stars, based on 1 article reviews
rabbit polyclonal emc4 antibody (catalog #: ap14717a) - by Bioz Stars, 2026-03
90/100 stars
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emc4 tmhs  (Federation of European Neuroscience Societies)
90
Federation of European Neuroscience Societies emc4 tmhs
(A) Topology of the nine-subunit human EMC. In mammals, the EMC is composed of seven membrane-spanning and two soluble subunits. The central insertase is composed of the two central subunits EMC3 (a homolog of YidC and member of the Oxa1 superfamily of insertases) and EMC6 ( ; ; ). In both yeast and humans, the EMC also contains a globular cytosolic domain (scaffolded around EMC2 and in mammals containing the redundant paralogs EMC8 or 9) and a large lumenal domain (composed of EMC1, 7, 10, and a single β-strand of <t>EMC4).</t> The function of the lumenal domain of the EMC is not known, but β -propellers, like those conserved in EMC1, are typically considered protein-protein interaction motifs. (B) Topology of the heterotrimeric BOS complex. NOMO contains 12 lumenal IgG repeats and a single C-terminal TMD. The single-spanning protein NCLN also has a large lumenal domain, and is homologous to nicastrin, a component of the γ-secretase complex . Finally, TMEM147 contains 7 TMDs and is homologous to APH-1 in the γ-secretase complex . (C) Flow cytometry analysis of the ratiometric ADRA1A protein reporter with or without the N-terminal fusion of the signal sequence (ss) of Pre-Prolactin followed by T4 Lysozyme (T4L), as described in . (D) Flow cytometry analysis of the ratiometric AGTR2 protein reporter with or without an N-terminal fusion of the first TMD of MAN1A1, a membrane protein of N cyt topology. Note that both the N-terminal fusion of MAN1A1 and of (ss)-T4 lysozyme behave similarly and rescue the NOMO kd and EMC5 kd phenotypes.
Emc4 Tmhs, supplied by Federation of European Neuroscience Societies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/emc4 tmhs/product/Federation of European Neuroscience Societies
Average 90 stars, based on 1 article reviews
emc4 tmhs - by Bioz Stars, 2026-03
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Image Search Results


(A) Topology of the nine-subunit human EMC. In mammals, the EMC is composed of seven membrane-spanning and two soluble subunits. The central insertase is composed of the two central subunits EMC3 (a homolog of YidC and member of the Oxa1 superfamily of insertases) and EMC6 ( ; ; ). In both yeast and humans, the EMC also contains a globular cytosolic domain (scaffolded around EMC2 and in mammals containing the redundant paralogs EMC8 or 9) and a large lumenal domain (composed of EMC1, 7, 10, and a single β-strand of EMC4). The function of the lumenal domain of the EMC is not known, but β -propellers, like those conserved in EMC1, are typically considered protein-protein interaction motifs. (B) Topology of the heterotrimeric BOS complex. NOMO contains 12 lumenal IgG repeats and a single C-terminal TMD. The single-spanning protein NCLN also has a large lumenal domain, and is homologous to nicastrin, a component of the γ-secretase complex . Finally, TMEM147 contains 7 TMDs and is homologous to APH-1 in the γ-secretase complex . (C) Flow cytometry analysis of the ratiometric ADRA1A protein reporter with or without the N-terminal fusion of the signal sequence (ss) of Pre-Prolactin followed by T4 Lysozyme (T4L), as described in . (D) Flow cytometry analysis of the ratiometric AGTR2 protein reporter with or without an N-terminal fusion of the first TMD of MAN1A1, a membrane protein of N cyt topology. Note that both the N-terminal fusion of MAN1A1 and of (ss)-T4 lysozyme behave similarly and rescue the NOMO kd and EMC5 kd phenotypes.

Journal: bioRxiv

Article Title: Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins

doi: 10.1101/2023.11.28.569054

Figure Lengend Snippet: (A) Topology of the nine-subunit human EMC. In mammals, the EMC is composed of seven membrane-spanning and two soluble subunits. The central insertase is composed of the two central subunits EMC3 (a homolog of YidC and member of the Oxa1 superfamily of insertases) and EMC6 ( ; ; ). In both yeast and humans, the EMC also contains a globular cytosolic domain (scaffolded around EMC2 and in mammals containing the redundant paralogs EMC8 or 9) and a large lumenal domain (composed of EMC1, 7, 10, and a single β-strand of EMC4). The function of the lumenal domain of the EMC is not known, but β -propellers, like those conserved in EMC1, are typically considered protein-protein interaction motifs. (B) Topology of the heterotrimeric BOS complex. NOMO contains 12 lumenal IgG repeats and a single C-terminal TMD. The single-spanning protein NCLN also has a large lumenal domain, and is homologous to nicastrin, a component of the γ-secretase complex . Finally, TMEM147 contains 7 TMDs and is homologous to APH-1 in the γ-secretase complex . (C) Flow cytometry analysis of the ratiometric ADRA1A protein reporter with or without the N-terminal fusion of the signal sequence (ss) of Pre-Prolactin followed by T4 Lysozyme (T4L), as described in . (D) Flow cytometry analysis of the ratiometric AGTR2 protein reporter with or without an N-terminal fusion of the first TMD of MAN1A1, a membrane protein of N cyt topology. Note that both the N-terminal fusion of MAN1A1 and of (ss)-T4 lysozyme behave similarly and rescue the NOMO kd and EMC5 kd phenotypes.

Article Snippet: The following antibodies were used in this study: EMC2 (25443-1-AP, Proteintech, USA); EMC3 (67205-1-Ig, Proteintech, USA); EMC4 (27708-1-AP, Proteintech, USA); EMC5 (A305-833, Bethyl Laboratories, USA); EMC7 (27550-1-AP, Proteintech, USA); EMC10 (ab180148, Abcam, UK); TMCO1 (27757-1-AP, Proteintech, USA); TMEM147 (PA5-95876, Invitrogen, USA); NCLN (A305-623A-M, Bethyl, USA); NOMO1 (PA5-47534, Invitrogen, USA); NOMO2 (PA5-95819, Invitrogen, USA); CCDC47 (A305-100A-M, Bethyl, USA); GET2 (Synaptic Systems, Germany); SYVN1 (13473-1-AP, Proteintech, USA); FAF2 (16251-1-AP, Proteintech, USA); UGGT1 (sc-374565, Santa Cruz Biotechnology, USA); Asterix (HPA06568S, Sigma Aldrich); Calnexin (10427-2-AP, Proteintech); BIP (#610979, BD Biosciences); PDI (ADI-SPA-891-D, Enzo, USA); alpha tubulin (T9026, Millipore Sigma, USA); Anti-HA-HRP (Millipore-Sigma, USA); Anti-FLAG-HRP (Millipore-Sigma, USA).

Techniques: Membrane, Flow Cytometry, Sequencing