Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries

doi: 10.1002/14651858.CD008122.pub2

Figure Lengend Snippet: RDT types and brands verified with microscopy

Article Snippet: Target condition and reference standard(s) Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Trained malaria technician Microscopy setting: Not stated Number of high power fields examined before declaring negative: 200 Number of observer or repeats: One, except in the case of discordant results between microscopy and RDTs Resolution of discrepancies between observers: All discordant results, all slides where only gametocytes were detected and a random sample of 20% of the remaining slides were checked blind by an independent trained laboratory technician Index and comparator tests Commerical name of RDTs: Paracheck Pf dipstick (Orchid Biomedical Systems, Goa, India) Paracheck Pf device (Orchid Biomedical Systems, Goa, India) (data not included in review as duplicates Paracheck Pf dipstick) ParaHIT‐f (Span diagnostics Ltd, Surat, India) (excluded as required data could not be extracted) BIO P.F (excluded as required data could not be extracted) Malaria Rapid (excluded as required data could not be extracted) Parasite(s) designed to detect: P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Two independent readers (persons unspecified) RDT setting: The research clinic Follow‐up Not applicable Notes Source of funding: Medicins sans Frontieres, French section.

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries

doi: 10.1002/14651858.CD008122.pub2

Figure Lengend Snippet: New Summary of results table

Article Snippet: Target condition and reference standard(s) Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Trained malaria technician Microscopy setting: Not stated Number of high power fields examined before declaring negative: 200 Number of observer or repeats: One, except in the case of discordant results between microscopy and RDTs Resolution of discrepancies between observers: All discordant results, all slides where only gametocytes were detected and a random sample of 20% of the remaining slides were checked blind by an independent trained laboratory technician Index and comparator tests Commerical name of RDTs: Paracheck Pf dipstick (Orchid Biomedical Systems, Goa, India) Paracheck Pf device (Orchid Biomedical Systems, Goa, India) (data not included in review as duplicates Paracheck Pf dipstick) ParaHIT‐f (Span diagnostics Ltd, Surat, India) (excluded as required data could not be extracted) BIO P.F (excluded as required data could not be extracted) Malaria Rapid (excluded as required data could not be extracted) Parasite(s) designed to detect: P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Two independent readers (persons unspecified) RDT setting: The research clinic Follow‐up Not applicable Notes Source of funding: Medicins sans Frontieres, French section.

Techniques: Diagnostic Assay, Microscopy, Sampling

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries

doi: 10.1002/14651858.CD008122.pub2

Figure Lengend Snippet: Paracheck‐Pf.

Article Snippet: Target condition and reference standard(s) Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Trained malaria technician Microscopy setting: Not stated Number of high power fields examined before declaring negative: 200 Number of observer or repeats: One, except in the case of discordant results between microscopy and RDTs Resolution of discrepancies between observers: All discordant results, all slides where only gametocytes were detected and a random sample of 20% of the remaining slides were checked blind by an independent trained laboratory technician Index and comparator tests Commerical name of RDTs: Paracheck Pf dipstick (Orchid Biomedical Systems, Goa, India) Paracheck Pf device (Orchid Biomedical Systems, Goa, India) (data not included in review as duplicates Paracheck Pf dipstick) ParaHIT‐f (Span diagnostics Ltd, Surat, India) (excluded as required data could not be extracted) BIO P.F (excluded as required data could not be extracted) Malaria Rapid (excluded as required data could not be extracted) Parasite(s) designed to detect: P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Two independent readers (persons unspecified) RDT setting: The research clinic Follow‐up Not applicable Notes Source of funding: Medicins sans Frontieres, French section.

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries

doi: 10.1002/14651858.CD008122.pub2

Figure Lengend Snippet: ParaHIT‐F.

Article Snippet: Target condition and reference standard(s) Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Trained malaria technician Microscopy setting: Not stated Number of high power fields examined before declaring negative: 200 Number of observer or repeats: One, except in the case of discordant results between microscopy and RDTs Resolution of discrepancies between observers: All discordant results, all slides where only gametocytes were detected and a random sample of 20% of the remaining slides were checked blind by an independent trained laboratory technician Index and comparator tests Commerical name of RDTs: Paracheck Pf dipstick (Orchid Biomedical Systems, Goa, India) Paracheck Pf device (Orchid Biomedical Systems, Goa, India) (data not included in review as duplicates Paracheck Pf dipstick) ParaHIT‐f (Span diagnostics Ltd, Surat, India) (excluded as required data could not be extracted) BIO P.F (excluded as required data could not be extracted) Malaria Rapid (excluded as required data could not be extracted) Parasite(s) designed to detect: P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Two independent readers (persons unspecified) RDT setting: The research clinic Follow‐up Not applicable Notes Source of funding: Medicins sans Frontieres, French section.

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries

doi: 10.1002/14651858.CD008122.pub2

Figure Lengend Snippet: PCR adjusted microscopy, Type 1, Paracheck‐PF (All).

Article Snippet: Target condition and reference standard(s) Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Trained malaria technician Microscopy setting: Not stated Number of high power fields examined before declaring negative: 200 Number of observer or repeats: One, except in the case of discordant results between microscopy and RDTs Resolution of discrepancies between observers: All discordant results, all slides where only gametocytes were detected and a random sample of 20% of the remaining slides were checked blind by an independent trained laboratory technician Index and comparator tests Commerical name of RDTs: Paracheck Pf dipstick (Orchid Biomedical Systems, Goa, India) Paracheck Pf device (Orchid Biomedical Systems, Goa, India) (data not included in review as duplicates Paracheck Pf dipstick) ParaHIT‐f (Span diagnostics Ltd, Surat, India) (excluded as required data could not be extracted) BIO P.F (excluded as required data could not be extracted) Malaria Rapid (excluded as required data could not be extracted) Parasite(s) designed to detect: P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Two independent readers (persons unspecified) RDT setting: The research clinic Follow‐up Not applicable Notes Source of funding: Medicins sans Frontieres, French section.

Techniques: Microscopy

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries

doi: 10.1002/14651858.CD008122.pub2

Figure Lengend Snippet: PCR, Type 1, ParaHIT‐F.

Article Snippet: Target condition and reference standard(s) Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Trained malaria technician Microscopy setting: Not stated Number of high power fields examined before declaring negative: 200 Number of observer or repeats: One, except in the case of discordant results between microscopy and RDTs Resolution of discrepancies between observers: All discordant results, all slides where only gametocytes were detected and a random sample of 20% of the remaining slides were checked blind by an independent trained laboratory technician Index and comparator tests Commerical name of RDTs: Paracheck Pf dipstick (Orchid Biomedical Systems, Goa, India) Paracheck Pf device (Orchid Biomedical Systems, Goa, India) (data not included in review as duplicates Paracheck Pf dipstick) ParaHIT‐f (Span diagnostics Ltd, Surat, India) (excluded as required data could not be extracted) BIO P.F (excluded as required data could not be extracted) Malaria Rapid (excluded as required data could not be extracted) Parasite(s) designed to detect: P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Two independent readers (persons unspecified) RDT setting: The research clinic Follow‐up Not applicable Notes Source of funding: Medicins sans Frontieres, French section.

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries

doi: 10.1002/14651858.CD008122.pub2

Figure Lengend Snippet: Data tables by test

Article Snippet: Target condition and reference standard(s) Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Trained malaria technician Microscopy setting: Not stated Number of high power fields examined before declaring negative: 200 Number of observer or repeats: One, except in the case of discordant results between microscopy and RDTs Resolution of discrepancies between observers: All discordant results, all slides where only gametocytes were detected and a random sample of 20% of the remaining slides were checked blind by an independent trained laboratory technician Index and comparator tests Commerical name of RDTs: Paracheck Pf dipstick (Orchid Biomedical Systems, Goa, India) Paracheck Pf device (Orchid Biomedical Systems, Goa, India) (data not included in review as duplicates Paracheck Pf dipstick) ParaHIT‐f (Span diagnostics Ltd, Surat, India) (excluded as required data could not be extracted) BIO P.F (excluded as required data could not be extracted) Malaria Rapid (excluded as required data could not be extracted) Parasite(s) designed to detect: P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Two independent readers (persons unspecified) RDT setting: The research clinic Follow‐up Not applicable Notes Source of funding: Medicins sans Frontieres, French section.

Techniques: Microscopy