ds5 Search Results


mouse lymphocytic hybridoma vu m75  (ATCC)
90
ATCC mouse lymphocytic hybridoma vu m75
Mouse Lymphocytic Hybridoma Vu M75, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse lymphocytic hybridoma vu m75/product/ATCC
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mouse lymphocytic hybridoma vu m75 - by Bioz Stars, 2026-03
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amitriptyline  (Chem Impex International)
95
Chem Impex International amitriptyline
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Amitriptyline, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/amitriptyline/product/Chem Impex International
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isolated bipolar current stimulator  (Digitimer North America LLC)
90
Digitimer North America LLC isolated bipolar current stimulator
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Isolated Bipolar Current Stimulator, supplied by Digitimer North America LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ds5 multiprobe  (Hydrolab Corporation)
90
Hydrolab Corporation ds5 multiprobe
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Ds5 Multiprobe, supplied by Hydrolab Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ds5 multiprobe/product/Hydrolab Corporation
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rectangular electrical pulses ds5&ds7  (Digitimer North America LLC)
90
Digitimer North America LLC rectangular electrical pulses ds5&ds7
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Rectangular Electrical Pulses Ds5&Ds7, supplied by Digitimer North America LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rectangular electrical pulses ds5&ds7/product/Digitimer North America LLC
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constant current pulses ds5  (Digitimer North America LLC)
90
Digitimer North America LLC constant current pulses ds5
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Constant Current Pulses Ds5, supplied by Digitimer North America LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/constant current pulses ds5/product/Digitimer North America LLC
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ds-5 capillary nebulizer  (CETEC GmbH)
90
CETEC GmbH ds-5 capillary nebulizer
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Ds 5 Capillary Nebulizer, supplied by CETEC GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ds-5 capillary nebulizer/product/CETEC GmbH
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multiparametric datasondes (ms5 ds5  (Hydrolab Corporation)
90
Hydrolab Corporation multiparametric datasondes (ms5 ds5
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Multiparametric Datasondes (Ms5 Ds5, supplied by Hydrolab Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/multiparametric datasondes (ms5 ds5/product/Hydrolab Corporation
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uv-vis absorption spectrometer ds5  (Edinburgh Instruments)
90
Edinburgh Instruments uv-vis absorption spectrometer ds5
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Uv Vis Absorption Spectrometer Ds5, supplied by Edinburgh Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ds5  (Digitimer Ltd)
90
Digitimer Ltd ds5
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Ds5, supplied by Digitimer Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ds5/product/Digitimer Ltd
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two ds5 isolated bipolar constant current stimulators  (Digitimer Ltd)
90
Digitimer Ltd two ds5 isolated bipolar constant current stimulators
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Two Ds5 Isolated Bipolar Constant Current Stimulators, supplied by Digitimer Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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miris2 ds5  (Whaledent Inc)
90
Whaledent Inc miris2 ds5
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Miris2 Ds5, supplied by Whaledent Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/miris2 ds5/product/Whaledent Inc
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Image Search Results


Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and amitriptyline (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.

Journal: Cell Reports Methods

Article Title: Profiling human iPSC-derived sensory neurons for analgesic drug screening using a multi-electrode array

doi: 10.1016/j.crmeth.2025.101051

Figure Lengend Snippet: Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and amitriptyline (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.

Article Snippet: Amitriptyline , Chem-Impex , Cat#37560.

Techniques: Activity Assay, Inhibition, Concentration Assay, Gene Expression