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  • 99
    Thermo Fisher affymetrix dmt software
    Affymetrix Dmt Software, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 24 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore dimethyl trisulfide dmts
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    TransGen biotech co dmt enzyme
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    ADInstruments dmt normalization module
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    Millipore 5 meo dmt oxalate
    Comparison of experimental and model predicted CBT profiles in wild-type and Tg- CYP2D6 mice treated with 10 mg/kg harmaline alone (A and B; n =14 in each group), 5 mg/kg <t>5-MeO-DMT</t> alone (C and D; n =4 in each group), and 5 mg/kg harmaline plus 5 mg/kg 5-MeO-DMT (E and F; n =4 in each group). For single dose study, drug was dosed i.p. at 0 min. For DDI study, harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .
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    TransGen biotech co dmt competent cells
    Comparison of experimental and model predicted CBT profiles in wild-type and Tg- CYP2D6 mice treated with 10 mg/kg harmaline alone (A and B; n =14 in each group), 5 mg/kg <t>5-MeO-DMT</t> alone (C and D; n =4 in each group), and 5 mg/kg harmaline plus 5 mg/kg 5-MeO-DMT (E and F; n =4 in each group). For single dose study, drug was dosed i.p. at 0 min. For DDI study, harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .
    Dmt Competent Cells, supplied by TransGen biotech co, used in various techniques. Bioz Stars score: 90/100, based on 43 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Novartis dmts
    Comparison of experimental and model predicted CBT profiles in wild-type and Tg- CYP2D6 mice treated with 10 mg/kg harmaline alone (A and B; n =14 in each group), 5 mg/kg <t>5-MeO-DMT</t> alone (C and D; n =4 in each group), and 5 mg/kg harmaline plus 5 mg/kg 5-MeO-DMT (E and F; n =4 in each group). For single dose study, drug was dosed i.p. at 0 min. For DDI study, harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .
    Dmts, supplied by Novartis, used in various techniques. Bioz Stars score: 91/100, based on 42 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Thermo Fisher dmt
    Comparison of experimental and model predicted CBT profiles in wild-type and Tg- CYP2D6 mice treated with 10 mg/kg harmaline alone (A and B; n =14 in each group), 5 mg/kg <t>5-MeO-DMT</t> alone (C and D; n =4 in each group), and 5 mg/kg harmaline plus 5 mg/kg 5-MeO-DMT (E and F; n =4 in each group). For single dose study, drug was dosed i.p. at 0 min. For DDI study, harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .
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    Thermo Fisher data mining tool dmt
    Comparison of experimental and model predicted CBT profiles in wild-type and Tg- CYP2D6 mice treated with 10 mg/kg harmaline alone (A and B; n =14 in each group), 5 mg/kg <t>5-MeO-DMT</t> alone (C and D; n =4 in each group), and 5 mg/kg harmaline plus 5 mg/kg 5-MeO-DMT (E and F; n =4 in each group). For single dose study, drug was dosed i.p. at 0 min. For DDI study, harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .
    Data Mining Tool Dmt, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 17 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Toronto Research Chemicals 1 o dmt 6 n fmoc 2 hydroxymethylhexane
    Comparison of experimental and model predicted CBT profiles in wild-type and Tg- CYP2D6 mice treated with 10 mg/kg harmaline alone (A and B; n =14 in each group), 5 mg/kg <t>5-MeO-DMT</t> alone (C and D; n =4 in each group), and 5 mg/kg harmaline plus 5 mg/kg 5-MeO-DMT (E and F; n =4 in each group). For single dose study, drug was dosed i.p. at 0 min. For DDI study, harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .
    1 O Dmt 6 N Fmoc 2 Hydroxymethylhexane, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Allen Institute for Brain Science 5 meo dmt targets
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    BOC Sciences boc dmt d arg pbf aba β ala oh
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    Sinopharm dimethyl terephthalate dmt
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    Tokyo Chemical Industry dmt mm
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
    Dmt Mm, supplied by Tokyo Chemical Industry, used in various techniques. Bioz Stars score: 88/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Thermo Fisher rabbit anti dmt 1 antibody
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
    Rabbit Anti Dmt 1 Antibody, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 92/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Millipore dimethyl tartaric acid dmt
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    dmt 1  (Abcam)
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    Abcam dmt 1
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    Thermo Fisher dmt 2 0
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    TransGen biotech co dmt enzymes
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    ChemGenes dmt hexaethyloxy glycol phosphoramidite
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    ChemGenes dmt triethyloxy glycol phosphoramidite
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    Becton Dickinson dmt
    Young GC in <t>5-MeO-DMT-treated</t> show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.
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    Image Search Results


    Comparison of experimental and model predicted CBT profiles in wild-type and Tg- CYP2D6 mice treated with 10 mg/kg harmaline alone (A and B; n =14 in each group), 5 mg/kg 5-MeO-DMT alone (C and D; n =4 in each group), and 5 mg/kg harmaline plus 5 mg/kg 5-MeO-DMT (E and F; n =4 in each group). For single dose study, drug was dosed i.p. at 0 min. For DDI study, harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .

    Journal: Acta Pharmaceutica Sinica. B

    Article Title: Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

    doi: 10.1016/j.apsb.2016.07.007

    Figure Lengend Snippet: Comparison of experimental and model predicted CBT profiles in wild-type and Tg- CYP2D6 mice treated with 10 mg/kg harmaline alone (A and B; n =14 in each group), 5 mg/kg 5-MeO-DMT alone (C and D; n =4 in each group), and 5 mg/kg harmaline plus 5 mg/kg 5-MeO-DMT (E and F; n =4 in each group). For single dose study, drug was dosed i.p. at 0 min. For DDI study, harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .

    Article Snippet: 2.1 Chemicals and materials Harmaline hydrochloride dihydrate and 5-MeO-DMT oxalate were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Mouse Assay

    Model estimation of the thermomodulatory effects in mice co-administered with harmaline and 5-MeO-DMT, including harmaline plus vehicle (A and B), vehicle plus 5-MeO-DMT (C and D), and various doses of harmaline plus 2 mg/kg 5-MeO-DMT (E and F) in wild-type ( n =11) and Tg- CYP2D6 ( n =12) mice. Harmaline and 5-MeO-DMT or corresponding vehicle were administered i.p. at 0 and 15 min, respectively. The solid (─), dashed (- -) and dotted (··) lines represent the fitted data with the ascending doses of respective drugs, which were obtained from simultaneous estimation using the PK/PD model shown in Fig. 1 .

    Journal: Acta Pharmaceutica Sinica. B

    Article Title: Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

    doi: 10.1016/j.apsb.2016.07.007

    Figure Lengend Snippet: Model estimation of the thermomodulatory effects in mice co-administered with harmaline and 5-MeO-DMT, including harmaline plus vehicle (A and B), vehicle plus 5-MeO-DMT (C and D), and various doses of harmaline plus 2 mg/kg 5-MeO-DMT (E and F) in wild-type ( n =11) and Tg- CYP2D6 ( n =12) mice. Harmaline and 5-MeO-DMT or corresponding vehicle were administered i.p. at 0 and 15 min, respectively. The solid (─), dashed (- -) and dotted (··) lines represent the fitted data with the ascending doses of respective drugs, which were obtained from simultaneous estimation using the PK/PD model shown in Fig. 1 .

    Article Snippet: 2.1 Chemicals and materials Harmaline hydrochloride dihydrate and 5-MeO-DMT oxalate were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Mouse Assay

    The PK/PD model for thermoregulation by serotonergic drugs harmaline and 5-MeO-DMT in wild-type and Tg- CYP2D6 mice. Abbreviations of Harmaline and 5-MeO-DMT PK parameters as well as thermoregulation PD parameters are defined under Materials and Methods. Model estimates are shown in Table 1 .

    Journal: Acta Pharmaceutica Sinica. B

    Article Title: Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

    doi: 10.1016/j.apsb.2016.07.007

    Figure Lengend Snippet: The PK/PD model for thermoregulation by serotonergic drugs harmaline and 5-MeO-DMT in wild-type and Tg- CYP2D6 mice. Abbreviations of Harmaline and 5-MeO-DMT PK parameters as well as thermoregulation PD parameters are defined under Materials and Methods. Model estimates are shown in Table 1 .

    Article Snippet: 2.1 Chemicals and materials Harmaline hydrochloride dihydrate and 5-MeO-DMT oxalate were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Mouse Assay

    Comparison of experimental and model simulated CBT profiles in wild-type ( n =11) and Tg- CYP2D6 ( n =12) mice treated with 2 (A and B), 5 (C and D) or 15 mg/kg (E and F) harmaline plus 10 mg/kg 5-MeO-DMT. Harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .

    Journal: Acta Pharmaceutica Sinica. B

    Article Title: Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

    doi: 10.1016/j.apsb.2016.07.007

    Figure Lengend Snippet: Comparison of experimental and model simulated CBT profiles in wild-type ( n =11) and Tg- CYP2D6 ( n =12) mice treated with 2 (A and B), 5 (C and D) or 15 mg/kg (E and F) harmaline plus 10 mg/kg 5-MeO-DMT. Harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─) lines represent the predicted data that were obtained from the developed PK/PD model shown in Fig. 1 .

    Article Snippet: 2.1 Chemicals and materials Harmaline hydrochloride dihydrate and 5-MeO-DMT oxalate were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Mouse Assay

    Model predicted serum harmaline (A and B) and 5-MeO-DMT (C and D) concentration versus time profiles following the administration of 2, 5 or 15 mg/kg harmaline plus 10 mg/kg 5-MeO-DMT, or 20 mg/kg 5-MeO-DMT alone in wild-type and Tg- CYP2D6 mice. Harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─), dashed (- -) and dotted (··) lines represent the simulated data of harmaline and 5-MeO-DMT in mice treated with ascending doses of harmaline (2–15 mg/kg) plus 10 mg/kg 5-MeO-DMT, while the dashed plus dotted (-·-) lines represent 5-MeO-DMT profiles in mice treated with 20 mg/kg 5-MeO-DMT alone. The PK profiles were obtained using our previously established PK DDI model 27 that is also shown in Fig. 1 .

    Journal: Acta Pharmaceutica Sinica. B

    Article Title: Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

    doi: 10.1016/j.apsb.2016.07.007

    Figure Lengend Snippet: Model predicted serum harmaline (A and B) and 5-MeO-DMT (C and D) concentration versus time profiles following the administration of 2, 5 or 15 mg/kg harmaline plus 10 mg/kg 5-MeO-DMT, or 20 mg/kg 5-MeO-DMT alone in wild-type and Tg- CYP2D6 mice. Harmaline and 5-MeO-DMT were dosed i.p. at 0 and 15 min, respectively. The solid (─), dashed (- -) and dotted (··) lines represent the simulated data of harmaline and 5-MeO-DMT in mice treated with ascending doses of harmaline (2–15 mg/kg) plus 10 mg/kg 5-MeO-DMT, while the dashed plus dotted (-·-) lines represent 5-MeO-DMT profiles in mice treated with 20 mg/kg 5-MeO-DMT alone. The PK profiles were obtained using our previously established PK DDI model 27 that is also shown in Fig. 1 .

    Article Snippet: 2.1 Chemicals and materials Harmaline hydrochloride dihydrate and 5-MeO-DMT oxalate were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Concentration Assay, Mouse Assay

    Model estimation of the hypothermia (A and B) and hyperthermia (C and D) in mice induced by harmaline and 5-MeO-DMT alone, respectively. Harmaline or 5-MeO-DMT was administered i.p. to wild-type and Tg- CYP2D6 mice ( n =14 in each group) at 0 min. The solid (─), dashed (- -) and dotted (··) lines represent the fitted data with the ascending doses of respective drugs, which were obtained from simultaneous estimation using the PK/PD model shown in Fig. 1 .

    Journal: Acta Pharmaceutica Sinica. B

    Article Title: Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

    doi: 10.1016/j.apsb.2016.07.007

    Figure Lengend Snippet: Model estimation of the hypothermia (A and B) and hyperthermia (C and D) in mice induced by harmaline and 5-MeO-DMT alone, respectively. Harmaline or 5-MeO-DMT was administered i.p. to wild-type and Tg- CYP2D6 mice ( n =14 in each group) at 0 min. The solid (─), dashed (- -) and dotted (··) lines represent the fitted data with the ascending doses of respective drugs, which were obtained from simultaneous estimation using the PK/PD model shown in Fig. 1 .

    Article Snippet: 2.1 Chemicals and materials Harmaline hydrochloride dihydrate and 5-MeO-DMT oxalate were purchased from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Mouse Assay

    Schematic representation of the changes in protein expression of NFAT and NF-κB pathways by 5-MeO-DMT. Canonical pathways showing upregulated (red) and downregulated proteins (green) after 5-MeO-DMT treatment.

    Journal: Scientific Reports

    Article Title: Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

    doi: 10.1038/s41598-017-12779-5

    Figure Lengend Snippet: Schematic representation of the changes in protein expression of NFAT and NF-κB pathways by 5-MeO-DMT. Canonical pathways showing upregulated (red) and downregulated proteins (green) after 5-MeO-DMT treatment.

    Article Snippet: After 24h, cells were treated for 4 days in quintuplicate (five wells per condition) with 5-MeO-DMT (Sigma-Aldrich) in N2B27 medium supplemented with bFGF and EGF.

    Techniques: Expressing

    Cerebral organoids express 5-MeO-DMT receptors and different cell type markers. (A) Cerebral organoids presenting smooth texture and homogeneous coloring at 45 days of differentiation (scale bar 1000 μm). (B) Cerebral organoids are composed of several cell types, including mature neurons, as shown by MAP2 staining. (C) Cells expressing AMPAR1 are found at the organoid edge, while (D) cells expressing NMDAR1 and (E) GFAP are detected within the organoid. (F) Cells positive for 5-HT 2A receptor, and (G) σ-1R, the primary molecular targets for 5-MeO-DMT, are also found in the organoid. Scale bars: A = 1000 μm; B = 50 μm; C, D, E, F, and G = 20 μm. (H) The expression of molecular targets for 5-MeO-DMT was also confirmed by RT-PCR.

    Journal: Scientific Reports

    Article Title: Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

    doi: 10.1038/s41598-017-12779-5

    Figure Lengend Snippet: Cerebral organoids express 5-MeO-DMT receptors and different cell type markers. (A) Cerebral organoids presenting smooth texture and homogeneous coloring at 45 days of differentiation (scale bar 1000 μm). (B) Cerebral organoids are composed of several cell types, including mature neurons, as shown by MAP2 staining. (C) Cells expressing AMPAR1 are found at the organoid edge, while (D) cells expressing NMDAR1 and (E) GFAP are detected within the organoid. (F) Cells positive for 5-HT 2A receptor, and (G) σ-1R, the primary molecular targets for 5-MeO-DMT, are also found in the organoid. Scale bars: A = 1000 μm; B = 50 μm; C, D, E, F, and G = 20 μm. (H) The expression of molecular targets for 5-MeO-DMT was also confirmed by RT-PCR.

    Article Snippet: After 24h, cells were treated for 4 days in quintuplicate (five wells per condition) with 5-MeO-DMT (Sigma-Aldrich) in N2B27 medium supplemented with bFGF and EGF.

    Techniques: Staining, Expressing, Reverse Transcription Polymerase Chain Reaction

    5-MeO-DMT treatment effects on human cerebral organoid proteomics. (A) Experimental design workflow. 45-day-old cerebral organoids were treated with either 5-MeO-DMT, vehicle, or left untreated for 24 h. Samples were analyzed using label-free state-of-the-art quantitative proteomics, using two-dimensional fractionation and high-resolution mass spectrometry. Workflow art was modified from 29 . (B) Venn diagram comparing the number of proteins identified by shotgun mass spectrometry in control human cerebral organoids, those treated with vehicle (EtOH), and 5-MeO-DMT. (C) Heat map showing significant functional enrichment between 5-MeO-DMT versus vehicle human cerebral organoids.

    Journal: Scientific Reports

    Article Title: Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

    doi: 10.1038/s41598-017-12779-5

    Figure Lengend Snippet: 5-MeO-DMT treatment effects on human cerebral organoid proteomics. (A) Experimental design workflow. 45-day-old cerebral organoids were treated with either 5-MeO-DMT, vehicle, or left untreated for 24 h. Samples were analyzed using label-free state-of-the-art quantitative proteomics, using two-dimensional fractionation and high-resolution mass spectrometry. Workflow art was modified from 29 . (B) Venn diagram comparing the number of proteins identified by shotgun mass spectrometry in control human cerebral organoids, those treated with vehicle (EtOH), and 5-MeO-DMT. (C) Heat map showing significant functional enrichment between 5-MeO-DMT versus vehicle human cerebral organoids.

    Article Snippet: After 24h, cells were treated for 4 days in quintuplicate (five wells per condition) with 5-MeO-DMT (Sigma-Aldrich) in N2B27 medium supplemented with bFGF and EGF.

    Techniques: Fractionation, Mass Spectrometry, Modification, Functional Assay

    Schematic representation of long term potentiation modulation by 5-MeO-DMT treatment. Z-scores were calculated from an upstream shortest-path analysis and gave the probability that the interaction between the proteins and the common regulator is not occurring by chance. In red, upregulated proteins; in green, downregulated proteins after 5-MeO-DMT treatment. Glu, glutamate.

    Journal: Scientific Reports

    Article Title: Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

    doi: 10.1038/s41598-017-12779-5

    Figure Lengend Snippet: Schematic representation of long term potentiation modulation by 5-MeO-DMT treatment. Z-scores were calculated from an upstream shortest-path analysis and gave the probability that the interaction between the proteins and the common regulator is not occurring by chance. In red, upregulated proteins; in green, downregulated proteins after 5-MeO-DMT treatment. Glu, glutamate.

    Article Snippet: After 24h, cells were treated for 4 days in quintuplicate (five wells per condition) with 5-MeO-DMT (Sigma-Aldrich) in N2B27 medium supplemented with bFGF and EGF.

    Techniques:

    Effects of 5-MeO-DMT on hNPCs. (A) Expression of mRNA for internal control (GAPDH), SR1, 5-HT 2A , and 5-HT 2C in hNPCs. (B) Confirmation of σ-1R protein (green) expression by immunocytochemistry, phalloidin showing the cytoskeleton (red) and DAPI staining nuclei (blue), scale bar 20 μm. (C) Quantification of cell proliferation based on EdU staining after treatment with 5-MeO-DMT. (D) Percentage of dead cells in hNPCs treated with 5-MeO-DMT. (E–H) Effects of 5-MeO-DMT on neuronal arborization by quantification of (E) total neurite length (sum of the length of all neurites attached to the cell), (F) number of segments, (G) number of extremities, and (H) number of nodes type 1. Bar represents median. Data were analyzed by one-way ANOVA with Tukey’s multiple comparison test, and only p-values

    Journal: Scientific Reports

    Article Title: Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

    doi: 10.1038/s41598-017-12779-5

    Figure Lengend Snippet: Effects of 5-MeO-DMT on hNPCs. (A) Expression of mRNA for internal control (GAPDH), SR1, 5-HT 2A , and 5-HT 2C in hNPCs. (B) Confirmation of σ-1R protein (green) expression by immunocytochemistry, phalloidin showing the cytoskeleton (red) and DAPI staining nuclei (blue), scale bar 20 μm. (C) Quantification of cell proliferation based on EdU staining after treatment with 5-MeO-DMT. (D) Percentage of dead cells in hNPCs treated with 5-MeO-DMT. (E–H) Effects of 5-MeO-DMT on neuronal arborization by quantification of (E) total neurite length (sum of the length of all neurites attached to the cell), (F) number of segments, (G) number of extremities, and (H) number of nodes type 1. Bar represents median. Data were analyzed by one-way ANOVA with Tukey’s multiple comparison test, and only p-values

    Article Snippet: After 24h, cells were treated for 4 days in quintuplicate (five wells per condition) with 5-MeO-DMT (Sigma-Aldrich) in N2B27 medium supplemented with bFGF and EGF.

    Techniques: Expressing, Immunocytochemistry, Staining

    Pathway showing influence of 5-MeO-DMT on cytoskeletal reorganization and dendritic spine morphogenesis. Canonical pathway showing upregulated (red) and downregulated (green) proteins.

    Journal: Scientific Reports

    Article Title: Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

    doi: 10.1038/s41598-017-12779-5

    Figure Lengend Snippet: Pathway showing influence of 5-MeO-DMT on cytoskeletal reorganization and dendritic spine morphogenesis. Canonical pathway showing upregulated (red) and downregulated (green) proteins.

    Article Snippet: After 24h, cells were treated for 4 days in quintuplicate (five wells per condition) with 5-MeO-DMT (Sigma-Aldrich) in N2B27 medium supplemented with bFGF and EGF.

    Techniques:

    Young GC in 5-MeO-DMT-treated show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.

    Journal: Frontiers in Molecular Neuroscience

    Article Title: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

    doi: 10.3389/fnmol.2018.00312

    Figure Lengend Snippet: Young GC in 5-MeO-DMT-treated show a higher frequency of spontaneous excitatory postsynaptic potentials. (A) Examples of detectedspontaneous excitatory postsynaptic currents (sEPSCs; in 2 min recordings) cells from saline- and 5-MeO-DMT-treated mice. (B) Mean absolute sEPSC amplitude for saline- and 5-MeO-DMT-treated mice. * p = 0.03. (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.001.

    Article Snippet: 5-HT1A , 5-HT2A and 5-HT2C , 5-MeO-DMT targets, are all expressed in the DG (Allen Institute for Brain Science , experiments n°: 79394355, 81671344 and 71393424, respectively).

    Techniques: Mouse Assay

    Single dose of 5-MeO-DMT increase the number of new DG granule cells (GC) 21 days after injection. (A) Photomicrography showing representative hippocampal sections (DCX::tdTom+ cells in red and hoechst 33342 in blue). (B) Average number of DCX::tdTom+ cells per group. * p = 0.0006.

    Journal: Frontiers in Molecular Neuroscience

    Article Title: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

    doi: 10.3389/fnmol.2018.00312

    Figure Lengend Snippet: Single dose of 5-MeO-DMT increase the number of new DG granule cells (GC) 21 days after injection. (A) Photomicrography showing representative hippocampal sections (DCX::tdTom+ cells in red and hoechst 33342 in blue). (B) Average number of DCX::tdTom+ cells per group. * p = 0.0006.

    Article Snippet: 5-HT1A , 5-HT2A and 5-HT2C , 5-MeO-DMT targets, are all expressed in the DG (Allen Institute for Brain Science , experiments n°: 79394355, 81671344 and 71393424, respectively).

    Techniques: Injection

    5-Meo-DMT injection alters afterhyperpolarization (AHP) duration and action potential (AP) threshold in immature hippocampus GC. (A) Animals received a dose of 100 μg of 5-MeO-DMT, followed by 100 μg/g of tamoxifen i.p. diluted in sesame oil 3 days after, daily for 3 days to allow cre recombination. Experiments were performed on day 21. (B) Photomicrography of a recorded tdTomato+ cells from control and 5-MeO-DMT-treated mouse. (C) Membrane potential changes in response to current steps, the black line denotes the trace in which the first AP was elicited, red dotted line denote AP threshold for that step. (D) Mean AP threshold. (E) Mean AHP duration. * p = 0.0216, ** p = 0.0062.

    Journal: Frontiers in Molecular Neuroscience

    Article Title: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

    doi: 10.3389/fnmol.2018.00312

    Figure Lengend Snippet: 5-Meo-DMT injection alters afterhyperpolarization (AHP) duration and action potential (AP) threshold in immature hippocampus GC. (A) Animals received a dose of 100 μg of 5-MeO-DMT, followed by 100 μg/g of tamoxifen i.p. diluted in sesame oil 3 days after, daily for 3 days to allow cre recombination. Experiments were performed on day 21. (B) Photomicrography of a recorded tdTomato+ cells from control and 5-MeO-DMT-treated mouse. (C) Membrane potential changes in response to current steps, the black line denotes the trace in which the first AP was elicited, red dotted line denote AP threshold for that step. (D) Mean AP threshold. (E) Mean AHP duration. * p = 0.0216, ** p = 0.0062.

    Article Snippet: 5-HT1A , 5-HT2A and 5-HT2C , 5-MeO-DMT targets, are all expressed in the DG (Allen Institute for Brain Science , experiments n°: 79394355, 81671344 and 71393424, respectively).

    Techniques: Injection

    Young GC in 5-MeO-DMT-treated mice show a greater capacity for high frequency firing. (A) Membrane potential recording in response to a current ramp. (B) Linear regressions (ramp current vs. instantaneous AP frequency). (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.0036.

    Journal: Frontiers in Molecular Neuroscience

    Article Title: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

    doi: 10.3389/fnmol.2018.00312

    Figure Lengend Snippet: Young GC in 5-MeO-DMT-treated mice show a greater capacity for high frequency firing. (A) Membrane potential recording in response to a current ramp. (B) Linear regressions (ramp current vs. instantaneous AP frequency). (C) Average slopes (ramp current vs. instantaneous AP frequency relationship). ** p = 0.0036.

    Article Snippet: 5-HT1A , 5-HT2A and 5-HT2C , 5-MeO-DMT targets, are all expressed in the DG (Allen Institute for Brain Science , experiments n°: 79394355, 81671344 and 71393424, respectively).

    Techniques: Mouse Assay

    Single dose of 5-MeO-DMT increases dendritic complexity in young DG GC. (A) Sample image showing a tdTomato+ (CreER T2 /tdTom lox/lox mouse) granule cell with visible dendritic processes. (B) Vectorial reconstruction of tdTomato+ granule cell. (C) Mean number of branch tips of GC across treatments. (D) Sholl analysis comparing the dendritic complexity between two treatments with increasing radial distance from soma. * p = 0.0001, ** p

    Journal: Frontiers in Molecular Neuroscience

    Article Title: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

    doi: 10.3389/fnmol.2018.00312

    Figure Lengend Snippet: Single dose of 5-MeO-DMT increases dendritic complexity in young DG GC. (A) Sample image showing a tdTomato+ (CreER T2 /tdTom lox/lox mouse) granule cell with visible dendritic processes. (B) Vectorial reconstruction of tdTomato+ granule cell. (C) Mean number of branch tips of GC across treatments. (D) Sholl analysis comparing the dendritic complexity between two treatments with increasing radial distance from soma. * p = 0.0001, ** p

    Article Snippet: 5-HT1A , 5-HT2A and 5-HT2C , 5-MeO-DMT targets, are all expressed in the DG (Allen Institute for Brain Science , experiments n°: 79394355, 81671344 and 71393424, respectively).

    Techniques: