Toronto Research Chemicals
tenofovir ![]() Tenofovir, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/result/tenofovir/product/Toronto Research Chemicals Average 93 stars, based on 1 article reviews Price from $9.99 to $1999.99
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2023-03
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Lee Biosolutions
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ATCC
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Covaris
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Nikon
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Image Search Results

Journal: Journal of Antimicrobial Chemotherapy
Article Title: Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues
doi: 10.1093/jac/dkx064
Figure Lengend Snippet: Median (IQR) tenofovir and tenofovir-dp in blood plasma and PBMCs following a single dose of tenofovir alafenamide. Tenofovir over 14 days in plasma (a) and tenofovir-dp in PBMCs (b). Plot inserts depict concentrations over 24 h for each matrix. Concentration values BLQ were imputed at half the LLOQ for graphing purposes. Broken horizontal lines represent the LLOQ. At least 32% of plasma samples had unquantifiable tenofovir and at least 8% of PBMC samples had unquantifiable tenofovir-dp. Percentage of samples that were BLQ at each sampling time is tabulated below each graph. TAF, tenofovir alafenamide.
Article Snippet: 1 mg/mL drug stocks were prepared by diluting tenofovir alafenamide (MedChem Express, Monmouth Junction, NJ, USA) in 100% DMSO and
Techniques: Concentration Assay, Sampling

Journal: Journal of Antimicrobial Chemotherapy
Article Title: Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues
doi: 10.1093/jac/dkx064
Figure Lengend Snippet: Tenofovir and tenofovir-dp NCA
Article Snippet: 1 mg/mL drug stocks were prepared by diluting tenofovir alafenamide (MedChem Express, Monmouth Junction, NJ, USA) in 100% DMSO and
Techniques:

Journal: Journal of Antimicrobial Chemotherapy
Article Title: Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues
doi: 10.1093/jac/dkx064
Figure Lengend Snippet: Median (IQR) tenofovir and tenofovir-dp in rectal tissues following a single dose of tenofovir alafenamide. Tenofovir (continuous lines) and tenofovir-dp (broken lines) over 14 days in rectal tissue. Concentration values BLQ were imputed at half the sample-specific LLOQ for graphing purposes. Representative LLOQs are depicted for tenofovir (continuous horizontal line) and tenofovir-dp (broken horizontal line). At least 25% and 69% of samples had unquantifiable tenofovir and tenofovir-dp, respectively. Percentage of samples that were BLQ at each sampling time is tabulated below the graph. TAF, tenofovir alafenamide; TFV, tenofovir; TFVdp, tenofovir-dp.
Article Snippet: 1 mg/mL drug stocks were prepared by diluting tenofovir alafenamide (MedChem Express, Monmouth Junction, NJ, USA) in 100% DMSO and
Techniques: Concentration Assay, Sampling

Journal: Journal of Antimicrobial Chemotherapy
Article Title: Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues
doi: 10.1093/jac/dkx064
Figure Lengend Snippet: Median (IQR) tenofovir and tenofovir-dp in female genital tissues following a single dose of tenofovir alafenamide. Tenofovir (continuous lines) and tenofovir-dp (broken lines) over 14 days in FGT tissue. Concentration values BLQ were imputed at half the sample-specific LLOQ for graphing purposes. Representative LLOQs are depicted for tenofovir (continuous horizontal line) and tenofovir-dp (broken horizontal line). At least 31% and 87.5% of samples had unquantifiable tenofovir and tenofovir-dp, respectively. Percentage of samples that were BLQ at each sampling time is tabulated below the graph. TAF, tenofovir alafenamide; TFV, tenofovir; TFVdp, tenofovir-dp.
Article Snippet: 1 mg/mL drug stocks were prepared by diluting tenofovir alafenamide (MedChem Express, Monmouth Junction, NJ, USA) in 100% DMSO and
Techniques: Concentration Assay, Sampling

Journal: Journal of Antimicrobial Chemotherapy
Article Title: Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues
doi: 10.1093/jac/dkx064
Figure Lengend Snippet: In vitro tenofovir-dp formation in PBMCs and epithelial cells
Article Snippet: 1 mg/mL drug stocks were prepared by diluting tenofovir alafenamide (MedChem Express, Monmouth Junction, NJ, USA) in 100% DMSO and
Techniques: In Vitro

Journal: Journal of Antimicrobial Chemotherapy
Article Title: Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues
doi: 10.1093/jac/dkx064
Figure Lengend Snippet: Median (range) tenofovir-dp in PBMCs and epithelial cells incubated in tenofovir and tenofovir alafenamide. Tenofovir-dp concentration over time in human PBMCs (triangles), Ect1/E6E7 ectocervical epithelial cells (circles) and VK2/E6E7 vaginal epithelial cells (squares) incubated in 0.5 μM (a) or 10 μM (b) tenofovir alafenamide (filled symbols and continuous lines) or tenofovir (open symbols and broken lines). Tenofovir-dp accumulation plateaued by 24 h in vaginal epithelial cells and 48 h in cervical epithelial cells and PBMCs for both tenofovir alafenamide and tenofovir.
Article Snippet: 1 mg/mL drug stocks were prepared by diluting tenofovir alafenamide (MedChem Express, Monmouth Junction, NJ, USA) in 100% DMSO and
Techniques: Incubation, Concentration Assay