Journal: Mammalian Genome

Article Title: Genome characterization of the selected long- and short-sleep mouse lines

doi: 10.1007/s00335-016-9663-6

Figure Lengend Snippet: Differences between ILS and ISS strains: Variant Breakdown. a Combined totals of variants that differ between the ILS and ISS strains. Synonymous mutations refer to a SNP(s) that alters the codon sequence but not the amino acid produced. Synonymous and non-synonymous mutations arise from the impact of a SNP on the underlying codon. Frameshifts are any indel not divisible by three, whereas deletions and insertions retain the reading frame. Variants are counted once per gene. b Combined totals of structural variations that differ between ILS and ISS strains. Losses and gains refer to changes in copy number, whereas a deletion is a complete loss/absence of a region. Chromosomal translocations refer to exchanges of large segments between chromosomes and inversions are reversals. c Distribution of structural variations by type, summarized by a sliding window approach (500 k windows with 100 k step size) (Color figure online)

Article Snippet: However, technological and analytical advances, including high-throughput gene expression analysis and “Next-Generation” deep sequencing technologies (NextGen), are providing an unprecedented opportunity to examine the molecular basis of QTLs (Harrison ).

Techniques: Variant Assay, Sequencing, Produced