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Tokyo Chemical Industry
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Merck KGaA
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Kodak
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Tokyo Chemical Industry
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Image Search Results
Journal: Drug Metabolism and Disposition
Article Title: Sorafenib Hepatobiliary Disposition: Mechanisms of Hepatic Uptake and Disposition of Generated Metabolites
doi: 10.1124/dmd.112.048181
Figure Lengend Snippet: Uptake of [14C]sorafenib (0.9 µM) in suspended human hepatocytes from two separate donors (A and B) over 2.5 minutes. Hepatocytes were incubated at 37°C (●) or 4°C (○) in standard buffer (mean ± S.D.; n = 2 livers in triplicate). Initial uptake of [14C]sorafenib (0.9 µM) at 0.5 minutes (C) and 1.5 minutes (D) in suspended human hepatocytes incubated at 37°C in standard buffer, unless otherwise specified, and in the presence of transport protein modulators, including choline buffer, inhibitors (rifamycin SV, decynium 22, and ketoprofen) and lower incubation temperature (n = 2 livers; mean percentage ± range).
Article Snippet: Sorafenib tosylate (purity 99.7%), [ 14 C]sorafenib (3.09 MBq/mg radiochemical purity 99.2%), the internal standard [ 2 H 3 , 15 N] sorafenib tosylate, and
Techniques: Incubation