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Image Search Results
Journal: Arthritis Research & Therapy
Article Title: B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin
doi: 10.1186/ar3879
Figure Lengend Snippet: Correlation between alpha smooth muscle actin and platelet-derived growth factor receptor expression . Immunohistochemical expression of (A) alpha smooth muscle actin (αSMA), (B) platelet-derived growth factor receptor (PDGFR)α and (C) PDGFRβ in spindle-like cells in Patient 5 prior to rituximab treatment (streptavidin-biotin peroxidase ×100). Red arrow in the boxed area points to a spindle-like cell (among others) expressing αSMA, PDGFRα and PDGFRβ.
Article Snippet: For the detection of PDGF-AA, PDGF-BB, PDGFRα, PDGFRβ, phospho-PDGFRα and phospho-PDGFRβ we employed a standard
Techniques: Derivative Assay, Expressing, Immunohistochemical staining
Journal: Arthritis Research & Therapy
Article Title: B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin
doi: 10.1186/ar3879
Figure Lengend Snippet: Phosphorylated platelet-derived growth factor receptor expression in the rituximab treated systemic sclerosis patients . Substantial reduction of collagen accumulation following rituximab (RTX) treatment (B) compared with baseline (A) in Patient 2 (Masson's trichrome ×100). Immunohistochemical staining for phosphorylated platelet-derived growth factor receptor (PDGFR)α and PDGFRβ in the same patient prior to ( (C) and (E) , respectively) and following ( (D) and (F) , respectively) RTX treatment, where a significant decrease in phospho-PDGFR staining can be seen (streptavidin peroxidase ×100). Red arrow in the boxed area points to a spindle-like cell (among others) expressing phosphorylated PDGFRα and PDGFRβ.
Article Snippet: For the detection of PDGF-AA, PDGF-BB, PDGFRα, PDGFRβ, phospho-PDGFRα and phospho-PDGFRβ we employed a standard
Techniques: Derivative Assay, Expressing, Immunohistochemical staining, Staining
Journal: Arthritis Research & Therapy
Article Title: B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin
doi: 10.1186/ar3879
Figure Lengend Snippet: Phosphorylated platelet-derived growth factor receptor expression in the control systemic sclerosis patients . Collagen accumulation does not improve in a control patient following cyclophosphamide treatment (B) compared with baseline (A) . Immunohistochemical staining for phosphorylated platelet-derived growth factor receptor (PDGFR)α and PDGFRβ in the same patient prior to ( (C) and (E) , respectively) and following ( (D) and (F) , respectively) rituximab (RTX) treatment, where no change in phospho-PDGFR staining can be seen (streptavidin peroxidase ×100). Red arrow in the boxed area points to a spindle-like cell (among others) expressing phosphorylated PDGFRα and PDGFRβ.
Article Snippet: For the detection of PDGF-AA, PDGF-BB, PDGFRα, PDGFRβ, phospho-PDGFRα and phospho-PDGFRβ we employed a standard
Techniques: Derivative Assay, Expressing, Control, Immunohistochemical staining, Staining