Journal: International Wound Journal

Article Title: Novel nitric oxide producing probiotic wound healing patch: preparation and in vivo analysis in a New Zealand white rabbit model of ischaemic and infected wounds

doi: 10.1111/j.1742-481X.2011.00889.x

Figure Lengend Snippet: (A) Top: chemistry for novel nitric oxide gas (gNO)‐producing probiotic patch in which gNO is generated from nitrite and protons produced by Lactobacillus fermentum NCIMB 7230 bacteria from glucose. (B) Bottom: cross section of novel gNO‐producing probiotic patch design. From the outermost to innermost layers, the patch is composed of (a) adhesive non occlusive Tegaderm™, (b) polyethylene/nylon laminated film, (c) immobilised bacteria L. fermentum NCIMB 7230 and a solution containing 10% glucose, 30 mM NaNO2 and 0·85% NaCl and (d) a layer of adhesive non occlusive Tegaderm™.

Article Snippet: The treatment was maintained for 20 or 21 days, irrespective of wound closure. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Nitric oxide gas (gNO) production by gNO‐producing probiotic patch containing 2·6 ml of glucose (10% w/v), sodium nitrite (30 mM) and 0·5 g lyophilised alginate microbeads containing 20% w/v immobilised Lactobacillus fermentum NCIMB 7230 by weight. gNO was detected using a Chemilumiescent Nitric Oxide Analyser (Sievers ® , GE) in a custom designed high‐density polyethylene chamber.

Techniques: Generated, Produced, Bacteria, Adhesive

Journal: Investigative Ophthalmology & Visual Science

Article Title: 24-Hour IOP Telemetry in the Nonhuman Primate: Implant System Performance and Initial Characterization of IOP at Multiple Timescales

doi: 10.1167/iovs.11-7955

Figure Lengend Snippet: (A) A typical T30F total implant system (Konigsberg Instruments, Pasadena, CA) showing the battery/transmitter module, radio frequency (RF) ring antenna for on/off, transmission antenna, a pressure transducer, and two ECG electrodes plus ground. (B) The extraorbital surface of the custom IOP transducer housing, which was secured within a 1/4-in. hole in the lateral orbital wall with bone screws, as shown in (C). A 23-gauge silicone tube delivered aqueous from the anterior chamber to a fluid reservoir on the intraorbital side of the transducer (partially hidden from view in B); The tube (with appropriate slack to allow for eye movement) was trimmed, inserted into the anterior chamber, sutured to the sclera using the integral scleral tube anchor plate, and covered with a scleral patch graft (not shown).

Article Snippet: To enable IOP telemetry, a standard P4 pressure transducer (Konigsberg Instruments) was integrated into a custom-designed silicone baseplate that is secured into the orbital wall with bone screws and connected to the anterior chamber via a 35-mm-long, 23-gauge silicone aqueous transduction tube ( ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 1. caption a7 ( A ) A typical T30F total implant system (Konigsberg Instruments, Pasadena, CA) showing the battery/transmitter module, radio frequency (RF) ring antenna for on/off, transmission antenna, a pressure transducer, and two ECG electrodes plus ground. ( B ) The extraorbital surface of the custom IOP transducer housing, which was secured within a 1/4-in. hole in the lateral orbital wall with bone screws, as shown in ( C ).

Techniques: Transmission Assay