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Image Search Results
Journal: The Journal of biological chemistry
Article Title: Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs.
doi: 10.1016/j.jbc.2023.104693
Figure Lengend Snippet: Figure 3. tatCN19o transiently affects learning but not memory. Error bars indicate SEM in all panels. A, schematic of the Contextual Fear Conditioning behavioral task (CFC) and timeline of saline or tatCN19o injections. Injections (1 mg/kg or 10 mg/kg i.v.) occurred either before (16, 4, 1, or 0.25 h) or after (0.25 h) the training session (2-foot shocks over the 6 min trial). For the test session 24 h later, the mice were returned to the chamber but received no foot shocks. Freezing response was measured across both days. B, quantification of freezing behavior during the first 2 min or last 4 min of the test session of the first set of experiments. Only the 15 min tatCN19o injection pre-learning cohort demonstrated a significant reduction in freezing behavior during the first 2 min (*p < 0.05 in one-way ANOVA with Bonferroni post-hoc test compared to the saline control condition, n = 18, 8, 7, 8, 9, 9 animals) or the last 4 min (one-way ANOVA, n = 18, 9, 9, 8, 9, 9 animals; #p < 0.05 compared to the condition of 4 h pre-injection). C, quantification of freezing behavior during the first 2 min and last 4 min of the second set of experiments, with all injections 1 h after learning (N.S. in unpaired t test, n = 18, 18 animals). D, quantification of freezing behavior during the first 2 min and last 4 min of the second set of experiments, separated by sex. There was no statistical difference detected by two-way ANOVA (n = 9, 9, 9, 9 animals). The apparent reduced freezing in the first 2 min period in females without compared to with tatCN19o treatment was significant only by direct comparison in an unpaired t test (#p < 0.05) and would indicate enhanced, not decreased, memory after tatCN19o injection.
Article Snippet: On the training day, the mice are placed into a
Techniques: Saline, Injection, Control, Comparison
Journal: Journal of Visualized Experiments : JoVE
Article Title: A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants
doi: 10.3791/53406
Figure Lengend Snippet:
Article Snippet:
Techniques: Control, Software