Journal: Lab on a chip

Article Title: Mass-Producible Microporous Silicon Membranes for Specific Leukocyte Subset Isolation, Immunophenotyping, and Personalized Immunomodulatory Drug Screening In Vitro

doi: 10.1039/c9lc00315k

Figure Lengend Snippet: Finite element modeling of the deflection of the SiMIPA microporous membrane under fluid flow. (a) Rendering from COMSOL showing the deflection of a membrane with 20 μm holes under a 2000 μL/sec flow rate. (b) A plot of the simulated deflection of a 3 × 3 × 0.05 mm3 Si membrane under different flow rates while the 3 × 0.05 mm2 faces are fixed. The membrane has a hexagonal lattice of pores through the 0.05 mm thick membrane where the center-to-center spacing is equal 30 μm. The linear regression line intercepts at y = 0 and has R2 = 0.9925. (c) Rendering from COMSOL showing the von Mises stress on a membrane with 20 μm holes under a 2000 μL/sec flow rate. (d) A plot of the simulated maximum von Mises stress observed on a 3 × 3 × 0.05 mm3 membrane under different flow rates while the 3 × 0.05 mm2 faces are fixed. The membrane has a hexagonal lattice of pores through the 0.05 mm thick membrane where the center-to-center spacing is 30 μm. The linear regression line intercepts at y = 0 and has R2 = 0.9925.

Article Snippet: The deflection profile of the entire membrane was reconstructed using the mirroring feature in COMSOL. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Fig. 3. caption a7 Finite element modeling of the deflection of the SiMIPA microporous membrane under fluid flow. (a) Rendering from COMSOL showing the deflection of a membrane with 20 μm holes under a 2000 μL/sec flow rate. (b) A plot of the simulated deflection of a 3 × 3 × 0.05 mm 3 Si membrane under different flow rates while the 3 × 0.05 mm 2 faces are fixed.

Techniques: Membrane