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Image Search Results
Journal: Frontiers in Immunology
Article Title: IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus
doi: 10.3389/fimmu.2021.624310
Figure Lengend Snippet: Protection against USA300 (NRS384) is mediated by vaccine-generated serum antibodies. (A) Lesion size and area under the curve after depletion of CD4 T cells in BSA-immunized and IBT-V02 immunized mice during infection, n = 5/group. (B) Toxin binding IgG titers tested on individual serum samples. (C) Toxin neutralizing titers tested on individual serum samples against Hla, and titers tested on serum pools/group against PVL, LukAB, SEA, SEB, and TSST-1 prior to CD4 T cells depletion. (D) Lesion size after passive transfer of naïve or immune sera previously generated in CD1 mice into BALB/c mice, n = 10/group. Statistical analysis performed using two-way ANOVA, Sidak's multiple comparisons test. (E) Area under the curve of infection-induced lesions after passive transfer of naïve sera or different dilutions of immune sera. Statistical analysis was performed by t -test using GraphPad PRISM v8.4.3. Siginificance symbols: * P ≤ 0.05; ** P ≤ 0.01; *** P ≤ 0.001; **** P ≤ 0.0001.
Article Snippet: For passive serum transfer studies,
Techniques: Generated, Infection, Binding Assay