Journal: Molecules

Article Title: Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders

doi: 10.3390/molecules27082520

Figure Lengend Snippet: Mechanism of action of classic serotonergic drugs. 5-HT serotonin receptors are densely located in areas of the brain that are responsible for mediation of mood and anxiety disorders such as the pre-frontal cortex [ , ]. Classic serotonergic psychedelic drugs such as LSD, DMT, 5-MeO-DMT, mescaline, psilocybin and MDMA all have an affinity for serotonergic 5-HT receptors which may mediate the psychotomimetic and pharmacological effects of psychedelic drugs. LSD may also interact with dopamine D2 receptors and trace-amine associated receptors (TAARs) to produce psychotomimetic and pharmacological effects . DMT also interacts agonistically with the sigma-1 receptor (Sig1R) [ , ] and trace-amine associated receptors (TAARs) to produce anti-inflammatory and anti-oxidant effects . In pre-clinical animal models, trace-amine associated receptors such as TAAR1 have been identified as a novel target for metabolic disorders, drug addiction, neurological and psychiatric diseases such as depression and schizophrenia [ , , , ].

Article Snippet: In 2018 Compass Pathways Ltd. (London, UK) received FDA approval of “breakthrough therapy” status for a psilocybin treatment they developed for treatment-resistant depression [ ].

Techniques:

Journal: Scientific Reports

Article Title: Utilization of a Wheat660K SNP array-derived high-density genetic map for high-resolution mapping of a major QTL for kernel number

doi: 10.1038/s41598-017-04028-6

Figure Lengend Snippet: Synteny of the mapped SNPs from the Wheat660K SNP array (in blue ) with that from the Wheat90K array (in red ) based on their common CSS-assembled contigs.

Article Snippet: Genomic DNA was extracted and hybridized on the Wheat660K SNP genotyping array by Compass Biotechnology Company (Beijing, China).

Techniques:

Journal: Scientific Reports

Article Title: Utilization of a Wheat660K SNP array-derived high-density genetic map for high-resolution mapping of a major QTL for kernel number

doi: 10.1038/s41598-017-04028-6

Figure Lengend Snippet: Synteny of the mapped SNPs from the Wheat660K SNP array (in blue ) with that from the Wheat820K array (in green ) based on their common CSS-assembled contigs. Notes: The genetic maps of chromosomes 3A, 4B, 5D, 6D and 7B derived from the Wheat820K SNP array are shown in inverted form, with long arms at the top and short arms at the bottom . In this figure, these inversions were corrected.

Article Snippet: Genomic DNA was extracted and hybridized on the Wheat660K SNP genotyping array by Compass Biotechnology Company (Beijing, China).

Techniques: Derivative Assay