colivelin tfa Search Results


colivelin tfa  (Shanghai Macklin Biochemical)
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Shanghai Macklin Biochemical colivelin tfa
EGCG regulates and improves the phosphorylation levels of proteins in the JAK2/STAT3 signaling pathway via its agonists and inhibitors. MLE-12 cells were inoculated in 6-well plates and grown to 60% confluence. The cells were incubated with Coumermycin A1, JAK-IN-21, <t>Colivelin</t> <t>TFA,</t> and Stattic in culture medium for 48 h. The medium was then refreshed, followed by a 24-h pretreatment with EGCG, and finally exposure to LPS for 10 h. (A–B) Protein levels of JAK2, p-JAK2, STAT3, and p-STAT3 were measured by western blotting. (C–D) Relative intensities of p-JAK2/JAK2 and p-STAT3/STAT3 were analyzed via ImageJ software. The data are presented as the means ± SEMs ( N = 3, #### P < 0.0001 versus the control group; ** P < 0.01 and **** P < 0.001 versus the LPS-treated group; & P < 0.05, &&& P < 0.001, &&&& P < 0.0001 versus the LPS + EGCG 7.5 µM group).
Colivelin Tfa, supplied by Shanghai Macklin Biochemical, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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colivelin tfa  (MuseChem Chemicals)
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Colivelin TFA(CAT: I046269) is a brain-penetrant neuroprotective peptide with high potency and multifunctional activity, acting as a strong activator of STAT3 signaling. It effectively suppresses neuronal death in vitro by activating STAT3 and Ca²⁺/calmodulin-dependent protein
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colivelin tfa  (TargetMol)
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colivelin tfa  (Aladdin Scientific Corporation)
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EGCG regulates and improves the phosphorylation levels of proteins in the JAK2/STAT3 signaling pathway via its agonists and inhibitors. MLE-12 cells were inoculated in 6-well plates and grown to 60% confluence. The cells were incubated with Coumermycin A1, JAK-IN-21, Colivelin TFA, and Stattic in culture medium for 48 h. The medium was then refreshed, followed by a 24-h pretreatment with EGCG, and finally exposure to LPS for 10 h. (A–B) Protein levels of JAK2, p-JAK2, STAT3, and p-STAT3 were measured by western blotting. (C–D) Relative intensities of p-JAK2/JAK2 and p-STAT3/STAT3 were analyzed via ImageJ software. The data are presented as the means ± SEMs ( N = 3, #### P < 0.0001 versus the control group; ** P < 0.01 and **** P < 0.001 versus the LPS-treated group; & P < 0.05, &&& P < 0.001, &&&& P < 0.0001 versus the LPS + EGCG 7.5 µM group).

Journal: Scientific Reports

Article Title: Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced inflammation via the 67LR/JAK2/STAT3 signaling pathway

doi: 10.1038/s41598-025-26875-4

Figure Lengend Snippet: EGCG regulates and improves the phosphorylation levels of proteins in the JAK2/STAT3 signaling pathway via its agonists and inhibitors. MLE-12 cells were inoculated in 6-well plates and grown to 60% confluence. The cells were incubated with Coumermycin A1, JAK-IN-21, Colivelin TFA, and Stattic in culture medium for 48 h. The medium was then refreshed, followed by a 24-h pretreatment with EGCG, and finally exposure to LPS for 10 h. (A–B) Protein levels of JAK2, p-JAK2, STAT3, and p-STAT3 were measured by western blotting. (C–D) Relative intensities of p-JAK2/JAK2 and p-STAT3/STAT3 were analyzed via ImageJ software. The data are presented as the means ± SEMs ( N = 3, #### P < 0.0001 versus the control group; ** P < 0.01 and **** P < 0.001 versus the LPS-treated group; & P < 0.05, &&& P < 0.001, &&&& P < 0.0001 versus the LPS + EGCG 7.5 µM group).

Article Snippet: Coumermycin A1 (Cat. No. 4434-05-3) and JAK/IN-21 (Cat. No. 2445499-20-5) were purchased from MedChemExpress Co., Ltd. Colivelin TFA (Cat. No. 2803948-60-7) and Stattic (Cat. No. 19983-44-9) were obtained from Shanghai Macklin Biochemical Co., Ltd. MLE-12 cells (passages 8–18) were acquired from the Meisen Chinese Tissue Culture Collections (CTCC-003-0020, Zhejiang Province, China).

Techniques: Phospho-proteomics, Incubation, Western Blot, Software, Control