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Image Search Results
Journal: The FASEB Journal
Article Title: Amelogenin Null Mice Develop Osteoarthritis, While Its Application Mitigates Disease Phenotypes in a Rat Model
doi: 10.1096/fj.202500827R
Figure Lengend Snippet: Immunohistochemical analyses of the knee joints from 12‐month‐old amelogenin‐null and wild‐type mice. Representative images of immunohistochemistry for type II collagen (A, C) and matrix metalloproteinase‐13 (MMP‐13) (B, D) in wild‐type (WT) (A, B) and amelogenin‐null (C, D) mice. Amelogenin‐null mice exhibited reduced type II collagen levels and increased MMP‐13 expression compared to wild‐type mice. These changes were accompanied by cartilage destruction and the presence of hypertrophic chondrocytes (black arrowheads). Enlarged pictures were taken from the regions marked with black frames. Brown staining indicates positive expression of type II collagen or MMP‐13. Scale bars: 250 μm for overall images; 62.5 μm for enlarged images.
Article Snippet:
Techniques: Immunohistochemical staining, Immunohistochemistry, Expressing, Staining