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Image Search Results
Journal: Nature
Article Title: Oncogene-like induction of cellular invasion from centrosome amplification.
doi: 10.1038/nature13277
Figure Lengend Snippet: Figure 1 | Invasive behaviour of epithelial cells triggered by centrosome amplification. a, Cells stained for microtubules (a-tubulin, red), centrioles (centrin2, green) andDNA (Hoechst, blue).Scale bar, 10 mm.Histogramshows fraction of cells with centrosome amplification. Error bars represent mean 6 s.e. from 3 independent experiments. b, Fraction of invasive acini in 3D cultures and representative images of normal acinus and an acinus with invasive protrusions. Scale bar, 10 mm. Error bars represent mean 6 s.e. from 4 independent experiments. c, Cells stained for F-actin (red), centrioles (centrin1–GFP, green, inset white) and DNA (blue). Scale bar, 10 mm. Histogram shows fraction of acini with centrosome amplification after PLK4 overexpression. Error bars represent mean 6 s.e. from 3 independent experiments. d, Scheme of the organotypic culture model used to assess
Article Snippet: Antibodies used included anti a-tubulin DM1a (1:500; Sigma-Aldrich),
Techniques: Amplification, Staining, Over Expression