Journal: Synapse (New York, N.Y.)

Article Title: Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex.

doi: 10.1002/syn.20640

Figure Lengend Snippet: Fig. 5. Mean (1SEM) % of saline optical density of mGluR5, Homer1b/c, and Homer2a/b in the N.Acc core of control, brief access and extended access animals at 1 and 14 days of withdrawal. * Rep- resents significant difference from saline control (P < 0.05).

Article Snippet: Although repeated i.p. cocaine administration protocols that are known to induce behavioral sensitization result in increased responsiveness of VTA neurons to glutamate administration, this increased responsiveness was mediated via AMPA receptors (White et al., 1995; Zhang et al., 1997), and such cocaine administration protocols fail to alter NR2a, NR2b (Fitzgerald et al., 1996), mGluR1, mGluR5, or Homer1b/c (Swanson et al., 2001) protein expression within the VTA.

Techniques: Saline, Control