calcium signaling Search Results


  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 99
    Thermo Fisher calcium oscillation
    Calcium Oscillation, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium oscillation/product/Thermo Fisher
    Average 99 stars, based on 7 article reviews
    Price from $9.99 to $1999.99
    calcium oscillation - by Bioz Stars, 2021-01
    99/100 stars
      Buy from Supplier

    98
    Millipore calcium signaling inhibitors nimodipine
    Calcium Signaling Inhibitors Nimodipine, supplied by Millipore, used in various techniques. Bioz Stars score: 98/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signaling inhibitors nimodipine/product/Millipore
    Average 98 stars, based on 4 article reviews
    Price from $9.99 to $1999.99
    calcium signaling inhibitors nimodipine - by Bioz Stars, 2021-01
    98/100 stars
      Buy from Supplier

    88
    Hausser Scientific m dendritic calcium signaling
    M Dendritic Calcium Signaling, supplied by Hausser Scientific, used in various techniques. Bioz Stars score: 88/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/m dendritic calcium signaling/product/Hausser Scientific
    Average 88 stars, based on 14 article reviews
    Price from $9.99 to $1999.99
    m dendritic calcium signaling - by Bioz Stars, 2021-01
    88/100 stars
      Buy from Supplier

    88
    Takeda k calcium oscillations
    K Calcium Oscillations, supplied by Takeda, used in various techniques. Bioz Stars score: 88/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/k calcium oscillations/product/Takeda
    Average 88 stars, based on 13 article reviews
    Price from $9.99 to $1999.99
    k calcium oscillations - by Bioz Stars, 2021-01
    88/100 stars
      Buy from Supplier

    80
    Humana Press fluometric imaging plate reader flipr calcium signaling protocols 1999new jersey
    Fluometric Imaging Plate Reader Flipr Calcium Signaling Protocols 1999new Jersey, supplied by Humana Press, used in various techniques. Bioz Stars score: 80/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fluometric imaging plate reader flipr calcium signaling protocols 1999new jersey/product/Humana Press
    Average 80 stars, based on 4 article reviews
    Price from $9.99 to $1999.99
    fluometric imaging plate reader flipr calcium signaling protocols 1999new jersey - by Bioz Stars, 2021-01
    80/100 stars
      Buy from Supplier

    91
    Learning and Memory possible signaling pathways mediating neuronal calcium sensor 1 dependent spatial learning
    Possible Signaling Pathways Mediating Neuronal Calcium Sensor 1 Dependent Spatial Learning, supplied by Learning and Memory, used in various techniques. Bioz Stars score: 91/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/possible signaling pathways mediating neuronal calcium sensor 1 dependent spatial learning/product/Learning and Memory
    Average 91 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    possible signaling pathways mediating neuronal calcium sensor 1 dependent spatial learning - by Bioz Stars, 2021-01
    91/100 stars
      Buy from Supplier

    90
    Doric Lenses Inc simultaneous calcium rsfmri signal recording a two wavelength gcamp fiber photometry system
    Correspondence between the global <t>rsfMRI</t> signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and <t>GCaMP</t> peaks (p = 0.016, 1000 permutations).
    Simultaneous Calcium Rsfmri Signal Recording A Two Wavelength Gcamp Fiber Photometry System, supplied by Doric Lenses Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/simultaneous calcium rsfmri signal recording a two wavelength gcamp fiber photometry system/product/Doric Lenses Inc
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    simultaneous calcium rsfmri signal recording a two wavelength gcamp fiber photometry system - by Bioz Stars, 2021-01
    90/100 stars
      Buy from Supplier

    90
    Putney cytoplasmic calcium oscillations
    Correspondence between the global <t>rsfMRI</t> signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and <t>GCaMP</t> peaks (p = 0.016, 1000 permutations).
    Cytoplasmic Calcium Oscillations, supplied by Putney, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cytoplasmic calcium oscillations/product/Putney
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    cytoplasmic calcium oscillations - by Bioz Stars, 2021-01
    90/100 stars
      Buy from Supplier

    90
    Putney bird gs 2014 calcium signaling
    Correspondence between the global <t>rsfMRI</t> signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and <t>GCaMP</t> peaks (p = 0.016, 1000 permutations).
    Bird Gs 2014 Calcium Signaling, supplied by Putney, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bird gs 2014 calcium signaling/product/Putney
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    bird gs 2014 calcium signaling - by Bioz Stars, 2021-01
    90/100 stars
      Buy from Supplier

    85
    4Gene calcium dependent signaling pathway
    Correspondence between the global <t>rsfMRI</t> signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and <t>GCaMP</t> peaks (p = 0.016, 1000 permutations).
    Calcium Dependent Signaling Pathway, supplied by 4Gene, used in various techniques. Bioz Stars score: 85/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium dependent signaling pathway/product/4Gene
    Average 85 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    calcium dependent signaling pathway - by Bioz Stars, 2021-01
    85/100 stars
      Buy from Supplier

    99
    Thermo Fisher calcium signal blocking reagent bapta am
    Correspondence between the global <t>rsfMRI</t> signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and <t>GCaMP</t> peaks (p = 0.016, 1000 permutations).
    Calcium Signal Blocking Reagent Bapta Am, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signal blocking reagent bapta am/product/Thermo Fisher
    Average 99 stars, based on 3 article reviews
    Price from $9.99 to $1999.99
    calcium signal blocking reagent bapta am - by Bioz Stars, 2021-01
    99/100 stars
      Buy from Supplier

    90
    Microsoft calcium signal expansion
    Correspondence between the global <t>rsfMRI</t> signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and <t>GCaMP</t> peaks (p = 0.016, 1000 permutations).
    Calcium Signal Expansion, supplied by Microsoft, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signal expansion/product/Microsoft
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    calcium signal expansion - by Bioz Stars, 2021-01
    90/100 stars
      Buy from Supplier

    99
    Thermo Fisher calcium signalling analysis
    Correspondence between the global <t>rsfMRI</t> signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and <t>GCaMP</t> peaks (p = 0.016, 1000 permutations).
    Calcium Signalling Analysis, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signalling analysis/product/Thermo Fisher
    Average 99 stars, based on 6 article reviews
    Price from $9.99 to $1999.99
    calcium signalling analysis - by Bioz Stars, 2021-01
    99/100 stars
      Buy from Supplier

    90
    Thermo Fisher human intracellular calcium signaling taqman array 96 well fastplate
    Correspondence between the global <t>rsfMRI</t> signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and <t>GCaMP</t> peaks (p = 0.016, 1000 permutations).
    Human Intracellular Calcium Signaling Taqman Array 96 Well Fastplate, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human intracellular calcium signaling taqman array 96 well fastplate/product/Thermo Fisher
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    human intracellular calcium signaling taqman array 96 well fastplate - by Bioz Stars, 2021-01
    90/100 stars
      Buy from Supplier

    90
    Thermo Fisher human intracellular calcium signaling taqman gene expression assay
    Correspondence between the global <t>rsfMRI</t> signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and <t>GCaMP</t> peaks (p = 0.016, 1000 permutations).
    Human Intracellular Calcium Signaling Taqman Gene Expression Assay, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human intracellular calcium signaling taqman gene expression assay/product/Thermo Fisher
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    human intracellular calcium signaling taqman gene expression assay - by Bioz Stars, 2021-01
    90/100 stars
      Buy from Supplier

    85
    Putney phospholipase c coupled calcium signalling system
    Isolated lacrimal acinar cells were loaded with the fluorescent calcium indicator fura-5F. In the presence of 1.8 m m  extracellular Ca 2+ , the responses to the phospholipase C-coupled agonist MeCh were compared in cells from WT and Orai1-KO mice.
    Phospholipase C Coupled Calcium Signalling System, supplied by Putney, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/phospholipase c coupled calcium signalling system/product/Putney
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    phospholipase c coupled calcium signalling system - by Bioz Stars, 2021-01
    85/100 stars
      Buy from Supplier

    85
    Xenobiotics signal transduction calcium
    Isolated lacrimal acinar cells were loaded with the fluorescent calcium indicator fura-5F. In the presence of 1.8 m m  extracellular Ca 2+ , the responses to the phospholipase C-coupled agonist MeCh were compared in cells from WT and Orai1-KO mice.
    Signal Transduction Calcium, supplied by Xenobiotics, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/signal transduction calcium/product/Xenobiotics
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    signal transduction calcium - by Bioz Stars, 2021-01
    85/100 stars
      Buy from Supplier

    99
    PerkinElmer calcium signaling drg neurons
    Isolated lacrimal acinar cells were loaded with the fluorescent calcium indicator fura-5F. In the presence of 1.8 m m  extracellular Ca 2+ , the responses to the phospholipase C-coupled agonist MeCh were compared in cells from WT and Orai1-KO mice.
    Calcium Signaling Drg Neurons, supplied by PerkinElmer, used in various techniques. Bioz Stars score: 99/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signaling drg neurons/product/PerkinElmer
    Average 99 stars, based on 2 article reviews
    Price from $9.99 to $1999.99
    calcium signaling drg neurons - by Bioz Stars, 2021-01
    99/100 stars
      Buy from Supplier

    93
    Cayman Chemical calcium signaling blocker btp 2
    Favorable effects of IGF-1, <t>BTP-2</t> monotherapies, and IGF-1 + BTP-2 combination therapies on LPS induced AKI associated major proinflammatory cytokines within the kidney. See text for interpretation. Data are mean ± SEM * p
    Calcium Signaling Blocker Btp 2, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signaling blocker btp 2/product/Cayman Chemical
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    calcium signaling blocker btp 2 - by Bioz Stars, 2021-01
    93/100 stars
      Buy from Supplier

    85
    Humana Press calcium signaling protocols 1999totowa
    Favorable effects of IGF-1, <t>BTP-2</t> monotherapies, and IGF-1 + BTP-2 combination therapies on LPS induced AKI associated major proinflammatory cytokines within the kidney. See text for interpretation. Data are mean ± SEM * p
    Calcium Signaling Protocols 1999totowa, supplied by Humana Press, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signaling protocols 1999totowa/product/Humana Press
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    calcium signaling protocols 1999totowa - by Bioz Stars, 2021-01
    85/100 stars
      Buy from Supplier

    90
    Humana Press calcium signaling
    Favorable effects of IGF-1, <t>BTP-2</t> monotherapies, and IGF-1 + BTP-2 combination therapies on LPS induced AKI associated major proinflammatory cytokines within the kidney. See text for interpretation. Data are mean ± SEM * p
    Calcium Signaling, supplied by Humana Press, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signaling/product/Humana Press
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    calcium signaling - by Bioz Stars, 2021-01
    90/100 stars
      Buy from Supplier

    99
    Millipore calcium signaling
    Favorable effects of IGF-1, <t>BTP-2</t> monotherapies, and IGF-1 + BTP-2 combination therapies on LPS induced AKI associated major proinflammatory cytokines within the kidney. See text for interpretation. Data are mean ± SEM * p
    Calcium Signaling, supplied by Millipore, used in various techniques. Bioz Stars score: 99/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signaling/product/Millipore
    Average 99 stars, based on 8 article reviews
    Price from $9.99 to $1999.99
    calcium signaling - by Bioz Stars, 2021-01
    99/100 stars
      Buy from Supplier

    90
    Putney calcium signaling
    Favorable effects of IGF-1, <t>BTP-2</t> monotherapies, and IGF-1 + BTP-2 combination therapies on LPS induced AKI associated major proinflammatory cytokines within the kidney. See text for interpretation. Data are mean ± SEM * p
    Calcium Signaling, supplied by Putney, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calcium signaling/product/Putney
    Average 90 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    calcium signaling - by Bioz Stars, 2021-01
    90/100 stars
      Buy from Supplier

    N/A
    The cAMP Ca2 Pathway Finder array features target genes that respond to cAMP or calcium ion Ca2 These genes contain SRE or SRE like enhancer sequences the CRE enhancer sequence
      Buy from Supplier

    N/A
    The cAMP Ca2 Pathway Finder array features target genes that respond to cAMP or calcium ion Ca2 These genes contain SRE or SRE like enhancer sequences the CRE enhancer sequence
      Buy from Supplier

    N/A
    The cAMP Ca2 Pathway Finder array features target genes that respond to cAMP or calcium ion Ca2 These genes contain SRE or SRE like enhancer sequences the CRE enhancer sequence
      Buy from Supplier

    N/A
    The cAMP Ca2 Pathway Finder array features target genes that respond to cAMP or calcium ion Ca2 These genes contain SRE or SRE like enhancer sequences the CRE enhancer sequence
      Buy from Supplier

    Image Search Results


    Correspondence between the global rsfMRI signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and GCaMP peaks (p = 0.016, 1000 permutations).

    Journal: Brain structure & function

    Article Title: Global brain signal in awake rats

    doi: 10.1007/s00429-019-01996-5

    Figure Lengend Snippet: Correspondence between the global rsfMRI signal and neuronal spikes in the hippocampus. (A) Representative time courses of the global rsfMRI signal (blue) and calcium signal (green). Global signal peaks (blue arrows) and neural spikes (red arrows) in the hippocampus were strongly coupled within 2–6 sec of hemodynamic delay. (B) Permutation test of the correspondence between the global signal and GCaMP peaks (p = 0.016, 1000 permutations).

    Article Snippet: Simultaneous calcium-rsfMRI signal recording A two-wavelength GCaMP fiber photometry system (Doric Lenses Inc., Quebec, Canada) was utilized for calcium signal recording ( ) ( ).

    Techniques:

    Isolated lacrimal acinar cells were loaded with the fluorescent calcium indicator fura-5F. In the presence of 1.8 m m  extracellular Ca 2+ , the responses to the phospholipase C-coupled agonist MeCh were compared in cells from WT and Orai1-KO mice.

    Journal: The Journal of Physiology

    Article Title: Role of Orai1 and store-operated calcium entry in mouse lacrimal gland signalling and function

    doi: 10.1113/jphysiol.2013.267740

    Figure Lengend Snippet: Isolated lacrimal acinar cells were loaded with the fluorescent calcium indicator fura-5F. In the presence of 1.8 m m extracellular Ca 2+ , the responses to the phospholipase C-coupled agonist MeCh were compared in cells from WT and Orai1-KO mice.

    Article Snippet: Lacrimal glands are responsive to both muscarinic and α-adrenergic stimulation, and the secretion of both fluid and protein appear to be dependent on the phospholipase C-coupled calcium signalling system (Dartt, ; Putney & Bird, ).

    Techniques: Isolation, Mouse Assay

    Favorable effects of IGF-1, BTP-2 monotherapies, and IGF-1 + BTP-2 combination therapies on LPS induced AKI associated major proinflammatory cytokines within the kidney. See text for interpretation. Data are mean ± SEM * p

    Journal: International Journal of Molecular Sciences

    Article Title: IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury

    doi: 10.3390/ijms21114095

    Figure Lengend Snippet: Favorable effects of IGF-1, BTP-2 monotherapies, and IGF-1 + BTP-2 combination therapies on LPS induced AKI associated major proinflammatory cytokines within the kidney. See text for interpretation. Data are mean ± SEM * p

    Article Snippet: Treatment In a preventive, therapeutic strategy, some of the mice received a dose of ~3.0 × 106 TU in a 20 μL volume of an intramuscular injection of Lenti-IGF-1 ( ) 24 h before LPS injection; whereas, the calcium signaling blocker BTP-2 (16 mg/kg, Cayman Chemical, Ann Arbor, MI, USA) was administrated 1 h before the LPS injection.

    Techniques:

    Favorable effects of IGF-1 and BTP-2 monotherapies and IGF-1 + BTP-2 combination therapy on LPS induced serum creatinine (Sr-CRT) and gene expression of the molecules reflecting kidney damage. See text for interpretation. Data are mean ± SEM * p

    Journal: International Journal of Molecular Sciences

    Article Title: IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury

    doi: 10.3390/ijms21114095

    Figure Lengend Snippet: Favorable effects of IGF-1 and BTP-2 monotherapies and IGF-1 + BTP-2 combination therapy on LPS induced serum creatinine (Sr-CRT) and gene expression of the molecules reflecting kidney damage. See text for interpretation. Data are mean ± SEM * p

    Article Snippet: Treatment In a preventive, therapeutic strategy, some of the mice received a dose of ~3.0 × 106 TU in a 20 μL volume of an intramuscular injection of Lenti-IGF-1 ( ) 24 h before LPS injection; whereas, the calcium signaling blocker BTP-2 (16 mg/kg, Cayman Chemical, Ann Arbor, MI, USA) was administrated 1 h before the LPS injection.

    Techniques: Expressing

    Favorable effects of therapies on LPS induced AKI expression of genes within the kidney related to the induction of calcium signaling. The target for BTP-2 is Orai1, which is decreased by this therapeutic agent as expected. See text for further interpretation. Data are mean ± SEM * p

    Journal: International Journal of Molecular Sciences

    Article Title: IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury

    doi: 10.3390/ijms21114095

    Figure Lengend Snippet: Favorable effects of therapies on LPS induced AKI expression of genes within the kidney related to the induction of calcium signaling. The target for BTP-2 is Orai1, which is decreased by this therapeutic agent as expected. See text for further interpretation. Data are mean ± SEM * p

    Article Snippet: Treatment In a preventive, therapeutic strategy, some of the mice received a dose of ~3.0 × 106 TU in a 20 μL volume of an intramuscular injection of Lenti-IGF-1 ( ) 24 h before LPS injection; whereas, the calcium signaling blocker BTP-2 (16 mg/kg, Cayman Chemical, Ann Arbor, MI, USA) was administrated 1 h before the LPS injection.

    Techniques: Expressing

    Experimental design for acute kidney injury (AKI) parameters such as survival, serum IGF-1 rescue and gene expression analysis in lipopolysaccharide (LPS) induced AKI animals treated with IGF-1 and BTP-2.

    Journal: International Journal of Molecular Sciences

    Article Title: IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury

    doi: 10.3390/ijms21114095

    Figure Lengend Snippet: Experimental design for acute kidney injury (AKI) parameters such as survival, serum IGF-1 rescue and gene expression analysis in lipopolysaccharide (LPS) induced AKI animals treated with IGF-1 and BTP-2.

    Article Snippet: Treatment In a preventive, therapeutic strategy, some of the mice received a dose of ~3.0 × 106 TU in a 20 μL volume of an intramuscular injection of Lenti-IGF-1 ( ) 24 h before LPS injection; whereas, the calcium signaling blocker BTP-2 (16 mg/kg, Cayman Chemical, Ann Arbor, MI, USA) was administrated 1 h before the LPS injection.

    Techniques: Expressing

    Schematic molecular pathway responses to the induction of AKI by LPS and the preventative therapeutic counteractions by IGF-1 and BTP-2. The left panel shows the effects of LPS, while the right panel shows the effects of combination therapy, IGF-1 + BTP-2. LPS initiates the destructive process by activating TLR-4, which leads to an enhancement of IP3 receptor activity in the ER, which in turn enhances the calcium reflux from the ER to the cytosol. The depletion of ER calcium activates plasma membrane calcium influx, via Stim, through Orai1/TRPC6 channels. The consequent increase in cytosol calcium propels the pathway that leads to inflammation and injury, as described in the text. On the right panel, the red X indicates the sites of action of combination therapy (IGF-1 + BTP-2), which had positive effects on all of the adverse system changes caused by LPS administration. The action of BTP-2 is to specifically inhibit Orai1 and TRPC6, which counteracts the effect of LPS on calcium influx into the cytosol. The function of BTP-2 to inhibit the calcium channel regulator is complemented by IGF-1, which acts on SERCA to increase calcium influx into the ER from the cytosol. The consequent decrease in cytosolic calcium counteracts much of the adverse actions of LPS, as described in the text.

    Journal: International Journal of Molecular Sciences

    Article Title: IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury

    doi: 10.3390/ijms21114095

    Figure Lengend Snippet: Schematic molecular pathway responses to the induction of AKI by LPS and the preventative therapeutic counteractions by IGF-1 and BTP-2. The left panel shows the effects of LPS, while the right panel shows the effects of combination therapy, IGF-1 + BTP-2. LPS initiates the destructive process by activating TLR-4, which leads to an enhancement of IP3 receptor activity in the ER, which in turn enhances the calcium reflux from the ER to the cytosol. The depletion of ER calcium activates plasma membrane calcium influx, via Stim, through Orai1/TRPC6 channels. The consequent increase in cytosol calcium propels the pathway that leads to inflammation and injury, as described in the text. On the right panel, the red X indicates the sites of action of combination therapy (IGF-1 + BTP-2), which had positive effects on all of the adverse system changes caused by LPS administration. The action of BTP-2 is to specifically inhibit Orai1 and TRPC6, which counteracts the effect of LPS on calcium influx into the cytosol. The function of BTP-2 to inhibit the calcium channel regulator is complemented by IGF-1, which acts on SERCA to increase calcium influx into the ER from the cytosol. The consequent decrease in cytosolic calcium counteracts much of the adverse actions of LPS, as described in the text.

    Article Snippet: Treatment In a preventive, therapeutic strategy, some of the mice received a dose of ~3.0 × 106 TU in a 20 μL volume of an intramuscular injection of Lenti-IGF-1 ( ) 24 h before LPS injection; whereas, the calcium signaling blocker BTP-2 (16 mg/kg, Cayman Chemical, Ann Arbor, MI, USA) was administrated 1 h before the LPS injection.

    Techniques: Activity Assay, Reflux