Journal: Reproductive Biology and Endocrinology : RB&E

Article Title: Cationic antimicrobial peptide, magainin down-regulates secretion of pro-inflammatory cytokines by early placental cytotrophoblasts

doi: 10.1186/s12958-015-0119-8

Figure Lengend Snippet: A snapshot of the top-scored pathway map based on the enrichment distribution sorted by ‘Statistically Significant Maps’ set using Metacore portal. This pathway map was retrieved from the significant pathways involved in inflammatory responses. Experimental data from all files is linked to and visualized on the maps as thermometer like figures ( red , down-regulated signals; blue , no change) to indicate vector component of the cytokine expression in the treatment groups. The cluster of cyto/chemokines which were markedly affected by AMA in the present study are shown in enclosures with broken red lines. B, binding; CM, covalent modification; Cn, competition; CS, complex subunit; IE, influence on expression; +P, phosphorylation; T, transformation; TR, transcription regulation; Z, catalysis. Green denotes positive effect. Red denotes negative effect

Article Snippet: The enrichment analysis and network constructions were achieved using a Metacore bioinformatics platform (GeneGO, St. Joseph, MI, USA) [ , , ].

Techniques: Plasmid Preparation, Expressing, Binding Assay, Modification, Phospho-proteomics, Transformation Assay