Journal: Biological & pharmaceutical bulletin

Article Title: Pharmacokinetics and brain distribution of tetrahydropalmatine and tetrahydroberberine after oral administration of DA-9701, a new botanical gastroprokinetic agent, in rats.

doi: 10.1248/bpb.b14-00678

Figure Lengend Snippet: Fig. 1. Chemical Structures of Tetrahydropalmatine (THP; A) and Tetrahydroberberine (THB; B)

Article Snippet: THP (purity 99.1%) and THB (purity 97.2%) were obtained from ChromaDex (Irvine, CA, U.S.A.).

Techniques:

Journal: Biological & pharmaceutical bulletin

Article Title: Pharmacokinetics and brain distribution of tetrahydropalmatine and tetrahydroberberine after oral administration of DA-9701, a new botanical gastroprokinetic agent, in rats.

doi: 10.1248/bpb.b14-00678

Figure Lengend Snippet: Fig. 4. Mean Plasma and Brain Concentration–Time Profiles of THP (A) and THB (B), and Their Brain-to-Plasma Concentration (Br/P) Ratios (C) Following Single Oral Administration of 328 mg/kg DA-9701 (Equivalent to 1.5 mg/kg THP and 0.39 mg/kg THB; n=3 at Each Time Point)

Article Snippet: THP (purity 99.1%) and THB (purity 97.2%) were obtained from ChromaDex (Irvine, CA, U.S.A.).

Techniques: Clinical Proteomics, Concentration Assay

Journal: Biological & pharmaceutical bulletin

Article Title: Pharmacokinetics and brain distribution of tetrahydropalmatine and tetrahydroberberine after oral administration of DA-9701, a new botanical gastroprokinetic agent, in rats.

doi: 10.1248/bpb.b14-00678

Figure Lengend Snippet: Fig. 5. Mean Plasma and Brain Concentration–Time Profiles of THP (A) and THB (B), and Their Brain-to-Plasma Concentration (Br/P) Ratios (C) Following Multiple Oral Administration of DA-9701 (150 mg/kg/d of DA-9701 for 7 d; Equivalent to 0.77 mg/kg/d as THP and 0.21 mg/kg/d as THB; n=4 at Each Time Point)

Article Snippet: THP (purity 99.1%) and THB (purity 97.2%) were obtained from ChromaDex (Irvine, CA, U.S.A.).

Techniques: Clinical Proteomics, Concentration Assay