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  • 93
    Bayer AG xylazine hydrochloride
    ECG waveforms recorded under 2 different anesthesia regimens. (A) ECG of a WHHLMI rabbit (male, 18 mo old) anesthetized with ketamine and <t>xylazine.</t> (B) ECG of a WHHLMI rabbit (female, 20 mo old) anesthetized with ketamine and midazolam.
    Xylazine Hydrochloride, supplied by Bayer AG, used in various techniques. Bioz Stars score: 93/100, based on 152 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Bayer AG ciprofloxacin
    Accumulation of fluoroquinolones by S. pneumoniae R6 and R6N ± CCCP. Light gray bars, fluoroquinolone alone; solid bars, fluoroquinolone plus CCCP. Grepa, grepafloxacin; Cip, <t>ciprofloxacin;</t> Nor, norfloxacin; Oflox, ofloxacin; Levo, levofloxacin; Moxi, moxifloxacin; Gati, gatifloxacin; Clina, clinafloxacin; Sita, sitafloxacin. Mean values ± standard deviations are shown.
    Ciprofloxacin, supplied by Bayer AG, used in various techniques. Bioz Stars score: 93/100, based on 475 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG gadoxetate disodium
    Gain or loss in sensitivity and specificity for the detection of affected liver segments for <t>gadoxetate</t> disodium (post [20 min]-pre) vs gadobenate dimeglumine (post [40 min]-pre), difference (%), bars indicate 95% confidence intervals. *Indicates statistical significance. HCC indicates hepatocellular carcinoma.
    Gadoxetate Disodium, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 155 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    Bayer AG nexavar
    Combination of poly-ICLC and <t>Sorafenib</t> enhanced tumor control in NSG mice NSG mice were transplanted with Hepa 1-6 cells and PBS or poly-ICLC (pIC) were treated as indicated in Figure 2A . A. Slowed tumor growth on d10, pIC+S: 39.7 ± 13.8 mm 2 vs. PBS: 75.3 ± 34.1 mm 2 , p = 0.02; on d14 pIC+S: 88.8 ± 42.6 mm 2 vs. PBS: 155.0 ± 31.1 mm 2 , p
    Nexavar, supplied by Bayer AG, used in various techniques. Bioz Stars score: 88/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG moxifloxacin
    The effect of JNJ-Q2 (p.o., squares), ciprofloxacin (i.p., triangles), and <t>moxifloxacin</t> (p.o., circles) on established MRSA ATCC 43300 skin infections. Each symbol represents the mean ± standard error for 14 to 16 mice. The starting inoculum was
    Moxifloxacin, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 243 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    89
    Bayer AG baytril
    In vitro antibacterial activity of <t>enrofloxacin</t> against Escherichia coli in MHB .
    Baytril, supplied by Bayer AG, used in various techniques. Bioz Stars score: 89/100, based on 120 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    84
    Bayer AG a5547 127
    In vitro antibacterial activity of <t>enrofloxacin</t> against Escherichia coli in MHB .
    A5547 127, supplied by Bayer AG, used in various techniques. Bioz Stars score: 84/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG gd dtpa
    Contrast agent uptake in the inguinal lymph nodes. ( a ) The uptake of <t>Gd-DTPA</t> into the LIN and RIN (arrows) is shown in single slice examples. Gd-DTPA uptake is minimally detected in the RIN, and not in the LIN. ( b ) Gd-LNP is taken up into the RIN but not into the LIN. ( c ) Gd-FVT contrast agent accumulates in the RIN and LIN, at 5 and at 15 min after injection. Scale bars are indicated.
    Gd Dtpa, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 71 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Bayer AG deltamethrin
    Histological sections of C . radiatus midgut stained with hematoxylin and eosin. ( A-C ): control treatment with no exposure to insecticide. ( D-F ): 1h exposure to <t>deltamethrin.</t> ( G-I ): 12 h exposure to deltamethrin. ( J-L ): 24 h exposure to deltamethrin. All exposure time were performed for the lowest deltamethrin concentration (0.25 μg of a.i/L) used in this study. lm : midgut lumen, pm : peritrophic membrane, nu : nuclei, ml : muscle layer, va : vacuolation, arrows : basophilic granules.
    Deltamethrin, supplied by Bayer AG, used in various techniques. Bioz Stars score: 93/100, based on 137 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Bayer AG betaconnect
    Attitudes and perceptions towards <t>BETACONNECT</t> in comparison with patients’ current autoinjectors, showing the percentage who scored statements 8, 9, or 10 (where 1 is strongly disagree and 10 is strongly agree). The percentages represent the proportion of patients who selected a rating of 8, 9, or 10 for each statement
    Betaconnect, supplied by Bayer AG, used in various techniques. Bioz Stars score: 91/100, based on 88 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG gadobutrol
    Comparison of injection speed. The full width at half maximum (FWHM) of the time intensity curve is plotted by injection speed in ( a ) (20 ml saline flush) and ( b ) (50 ml saline flush). The maximum signal change ratio (SCR max ) for various injection speeds is shown in ( c ) (20-ml saline flush) and ( d ) (50 ml saline flush). The mean values with 1 standard deviation for the measurements are presented. White markers and dotted regression lines represent the results for <t>gadobutrol,</t> and black markers and solid regression lines represent gadoteridol. Note that the FWHM does not show any statistical difference with the GBCM type, injection speed, or flush volume. However, the SCR max showed a correlation with the injection speed and flush volume. We found a statistically significant difference between the regression line for gadobutrol versus gadoteridol, indicating that gadobutrol had a larger signal drop compared to gadoteridol for both the 20 and 50 ml saline flush.
    Gadobutrol, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 203 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG rivaroxaban
    (A) Reduction in thrombus formation and (B) prolongation of prothrombin time with <t>rivaroxaban</t> in a rabbit arteriovenous shunt model. Each value represents the mean ± SEM of six animals. * p
    Rivaroxaban, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 135 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    93
    Bayer AG aprotinin
    <t>Aprotinin</t> Inhibits Apoptosis via Mitochondrial Pathway and 250KIU/ml is an Optimal Dose for Protection
    Aprotinin, supplied by Bayer AG, used in various techniques. Bioz Stars score: 93/100, based on 170 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG glucometer
    AM overexpression in PaC in vivo leads to the development of glucose intolerance. ( A ) MPanc96 luciferase cells were injected subcutaneously and orthotopically in athymic nude mice (n = 10) and pancreatic tumor was developed. Wild-type mice served as control. By bioluminescence imaging, tumors were size matched, mice were subjected to glucose tolerance tests, and blood glucose levels were measured using a <t>glucometer</t> at different time points. Mice bearing both subcutaneous and orthotopic tumors showed a significant increase ( P
    Glucometer, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 118 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG imidacloprid
    Survival for 14 days of four species of adult lady beetles that were allowed to feed on flowers from Mexican milkweed, Asclepias curassavica , plants that were untreated (C), treated with label rate (1X), or twice label rate (2X) rate of soil-applied <t>imidacloprid</t> (Marathon 1%G). Flowers were presented in opposite ends of a tube cage (C-C, 1X-C, 1X-1X, 2X-C, 2X-2X).
    Imidacloprid, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 96 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG acarbose
    Percent α-glucosidase inhibition by plant extracts and isolated compound D. <t>Acarbose</t> is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].
    Acarbose, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 73 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG aspirin
    Percent α-glucosidase inhibition by plant extracts and isolated compound D. <t>Acarbose</t> is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].
    Aspirin, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 49 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    95
    Bayer AG basilea pharmaceutica
    Percent α-glucosidase inhibition by plant extracts and isolated compound D. <t>Acarbose</t> is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].
    Basilea Pharmaceutica, supplied by Bayer AG, used in various techniques. Bioz Stars score: 95/100, based on 44 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG hba1c
    Venn diagram displaying the co-associations of chronic kidney disease (CKD), hypertension, and <t>HbA1c.</t>
    Hba1c, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 50 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Bayer AG regorafenib
    Total bilirubin, AST and ALT plasma levels (mean ±) in the overall population during treatment with <t>regorafenib</t> and silybin
    Regorafenib, supplied by Bayer AG, used in various techniques. Bioz Stars score: 91/100, based on 77 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Bayer AG resovist
    Average baseline signal strength of <t>Resovist</t> ® from Bayer Pharma AG and from I’rom Pharmaceutical Co Ltd. Notes: The first five odd harmonics of the excitation frequency f 0 =25 kHz are shown. There is no statistically significant difference in signal strength at baseline, indicating a similar performance of both products in MPI considering the MPI signal. The noise level of the MPS system is indicated by the dotted gray line. Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.
    Resovist, supplied by Bayer AG, used in various techniques. Bioz Stars score: 91/100, based on 103 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    91
    Bayer AG dca 2000 analyzer
    Average baseline signal strength of <t>Resovist</t> ® from Bayer Pharma AG and from I’rom Pharmaceutical Co Ltd. Notes: The first five odd harmonics of the excitation frequency f 0 =25 kHz are shown. There is no statistically significant difference in signal strength at baseline, indicating a similar performance of both products in MPI considering the MPI signal. The noise level of the MPS system is indicated by the dotted gray line. Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.
    Dca 2000 Analyzer, supplied by Bayer AG, used in various techniques. Bioz Stars score: 91/100, based on 85 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    89
    Bayer AG glucometer elite
    Average baseline signal strength of <t>Resovist</t> ® from Bayer Pharma AG and from I’rom Pharmaceutical Co Ltd. Notes: The first five odd harmonics of the excitation frequency f 0 =25 kHz are shown. There is no statistically significant difference in signal strength at baseline, indicating a similar performance of both products in MPI considering the MPI signal. The noise level of the MPS system is indicated by the dotted gray line. Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.
    Glucometer Elite, supplied by Bayer AG, used in various techniques. Bioz Stars score: 89/100, based on 84 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    Bayer AG ag bayer healthcare pharmaceuticals
    Average baseline signal strength of <t>Resovist</t> ® from Bayer Pharma AG and from I’rom Pharmaceutical Co Ltd. Notes: The first five odd harmonics of the excitation frequency f 0 =25 kHz are shown. There is no statistically significant difference in signal strength at baseline, indicating a similar performance of both products in MPI considering the MPI signal. The noise level of the MPS system is indicated by the dotted gray line. Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.
    Ag Bayer Healthcare Pharmaceuticals, supplied by Bayer AG, used in various techniques. Bioz Stars score: 88/100, based on 47 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    92
    Bayer AG axsome therapeutics
    Average baseline signal strength of <t>Resovist</t> ® from Bayer Pharma AG and from I’rom Pharmaceutical Co Ltd. Notes: The first five odd harmonics of the excitation frequency f 0 =25 kHz are shown. There is no statistically significant difference in signal strength at baseline, indicating a similar performance of both products in MPI considering the MPI signal. The noise level of the MPS system is indicated by the dotted gray line. Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.
    Axsome Therapeutics, supplied by Bayer AG, used in various techniques. Bioz Stars score: 92/100, based on 21 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    ECG waveforms recorded under 2 different anesthesia regimens. (A) ECG of a WHHLMI rabbit (male, 18 mo old) anesthetized with ketamine and xylazine. (B) ECG of a WHHLMI rabbit (female, 20 mo old) anesthetized with ketamine and midazolam.

    Journal: Comparative Medicine

    Article Title: Electrocardiograms Corresponding to the Development of Myocardial Infarction in Anesthetized WHHLMI Rabbits (Oryctolagus cuniculus), an Animal Model for Familial Hypercholesterolemia

    doi:

    Figure Lengend Snippet: ECG waveforms recorded under 2 different anesthesia regimens. (A) ECG of a WHHLMI rabbit (male, 18 mo old) anesthetized with ketamine and xylazine. (B) ECG of a WHHLMI rabbit (female, 20 mo old) anesthetized with ketamine and midazolam.

    Article Snippet: Ketamine hydrochloride (Ketalar, Daiichi-Sankyo, Tokyo, Japan), midazolam (Dormicum, Astellas Pharma, Tokyo, Japan), and xylazine hydrochloride (Seractar, Bayer Yakuhin, Tokyo, Japan) were used in various combinations to sedate or anesthetize study animals.

    Techniques:

    Accumulation of fluoroquinolones by S. pneumoniae R6 and R6N ± CCCP. Light gray bars, fluoroquinolone alone; solid bars, fluoroquinolone plus CCCP. Grepa, grepafloxacin; Cip, ciprofloxacin; Nor, norfloxacin; Oflox, ofloxacin; Levo, levofloxacin; Moxi, moxifloxacin; Gati, gatifloxacin; Clina, clinafloxacin; Sita, sitafloxacin. Mean values ± standard deviations are shown.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Accumulation of 10 Fluoroquinolones by Wild-Type or Efflux Mutant Streptococcus pneumoniae

    doi: 10.1128/AAC.46.3.813-820.2002

    Figure Lengend Snippet: Accumulation of fluoroquinolones by S. pneumoniae R6 and R6N ± CCCP. Light gray bars, fluoroquinolone alone; solid bars, fluoroquinolone plus CCCP. Grepa, grepafloxacin; Cip, ciprofloxacin; Nor, norfloxacin; Oflox, ofloxacin; Levo, levofloxacin; Moxi, moxifloxacin; Gati, gatifloxacin; Clina, clinafloxacin; Sita, sitafloxacin. Mean values ± standard deviations are shown.

    Article Snippet: All antibiotics were gifts and were made up and used according to the manufacturers' instructions: ciprofloxacin and moxifloxacin, Bayer AG, Leverkusen, Germany; sparfloxacin, Rhone DPC Europe, Paris, France; grepafloxacin, GlaxoWellcome, Uxbridge, United Kingdom; gatifloxacin, Grunenthal GmBH, Aachen,Germany; clinafloxacin, Parke-Davis Warner Lambert, Somerville, N.J.; levofloxacin, Hoechst Marion Roussel, Strasbourg, France; sitafloxacin, Daiichi, Tokyo, Japan; norfloxacin, tetracycline, chloramphenicol, and acriflavine, Sigma, St. Louis, Mo.

    Techniques:

    Accumulation of fluoroquinolones by S. pneumoniae M3 (light gray bars), M4 (black bars), and R6 (white bars). Grepa, grepafloxacin; Cip, ciprofloxacin; Nor, norfloxacin; Oflox, ofloxacin; Levo, levofloxacin; Moxi, moxifloxacin; Gati, gatifloxacin; Clina, clinafloxacin; Sita, sitafloxacin; Trova, trovafloxacin. Mean values ± standard deviations are shown. (Error bars show standard deviations.)

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Accumulation of 10 Fluoroquinolones by Wild-Type or Efflux Mutant Streptococcus pneumoniae

    doi: 10.1128/AAC.46.3.813-820.2002

    Figure Lengend Snippet: Accumulation of fluoroquinolones by S. pneumoniae M3 (light gray bars), M4 (black bars), and R6 (white bars). Grepa, grepafloxacin; Cip, ciprofloxacin; Nor, norfloxacin; Oflox, ofloxacin; Levo, levofloxacin; Moxi, moxifloxacin; Gati, gatifloxacin; Clina, clinafloxacin; Sita, sitafloxacin; Trova, trovafloxacin. Mean values ± standard deviations are shown. (Error bars show standard deviations.)

    Article Snippet: All antibiotics were gifts and were made up and used according to the manufacturers' instructions: ciprofloxacin and moxifloxacin, Bayer AG, Leverkusen, Germany; sparfloxacin, Rhone DPC Europe, Paris, France; grepafloxacin, GlaxoWellcome, Uxbridge, United Kingdom; gatifloxacin, Grunenthal GmBH, Aachen,Germany; clinafloxacin, Parke-Davis Warner Lambert, Somerville, N.J.; levofloxacin, Hoechst Marion Roussel, Strasbourg, France; sitafloxacin, Daiichi, Tokyo, Japan; norfloxacin, tetracycline, chloramphenicol, and acriflavine, Sigma, St. Louis, Mo.

    Techniques:

    Effect of glucose upon accumulation of ciprofloxacin by S. pneumoniae M3 and M4. Dark gray bars, ciprofloxacin (Cip) alone; black bars, ciprofloxacin plus reserpine; white bars, ciprofloxacin plus glucose; light gray bars, ciprofloxacin plus glucose plus reserpine. Data are from a single experiment.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Accumulation of 10 Fluoroquinolones by Wild-Type or Efflux Mutant Streptococcus pneumoniae

    doi: 10.1128/AAC.46.3.813-820.2002

    Figure Lengend Snippet: Effect of glucose upon accumulation of ciprofloxacin by S. pneumoniae M3 and M4. Dark gray bars, ciprofloxacin (Cip) alone; black bars, ciprofloxacin plus reserpine; white bars, ciprofloxacin plus glucose; light gray bars, ciprofloxacin plus glucose plus reserpine. Data are from a single experiment.

    Article Snippet: All antibiotics were gifts and were made up and used according to the manufacturers' instructions: ciprofloxacin and moxifloxacin, Bayer AG, Leverkusen, Germany; sparfloxacin, Rhone DPC Europe, Paris, France; grepafloxacin, GlaxoWellcome, Uxbridge, United Kingdom; gatifloxacin, Grunenthal GmBH, Aachen,Germany; clinafloxacin, Parke-Davis Warner Lambert, Somerville, N.J.; levofloxacin, Hoechst Marion Roussel, Strasbourg, France; sitafloxacin, Daiichi, Tokyo, Japan; norfloxacin, tetracycline, chloramphenicol, and acriflavine, Sigma, St. Louis, Mo.

    Techniques:

    Relationship between hydrophobicity and the mean SSC of each fluoroquinolone accumulated by S. pneumoniae M4 (A) and the molecular size of the free form and the mean SSC of each fluoroquinolone accumulated by S. pneumoniae M3 (B). Cip, ciprofloxacin; Nor, norfloxacin; Oflox, ofloxacin; Levo, levofloxacin; Moxi, moxifloxacin; Gati, gatifloxacin; Clina, clinafloxacin; Sita, sitafloxacin; Trova, trovafloxacin.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Accumulation of 10 Fluoroquinolones by Wild-Type or Efflux Mutant Streptococcus pneumoniae

    doi: 10.1128/AAC.46.3.813-820.2002

    Figure Lengend Snippet: Relationship between hydrophobicity and the mean SSC of each fluoroquinolone accumulated by S. pneumoniae M4 (A) and the molecular size of the free form and the mean SSC of each fluoroquinolone accumulated by S. pneumoniae M3 (B). Cip, ciprofloxacin; Nor, norfloxacin; Oflox, ofloxacin; Levo, levofloxacin; Moxi, moxifloxacin; Gati, gatifloxacin; Clina, clinafloxacin; Sita, sitafloxacin; Trova, trovafloxacin.

    Article Snippet: All antibiotics were gifts and were made up and used according to the manufacturers' instructions: ciprofloxacin and moxifloxacin, Bayer AG, Leverkusen, Germany; sparfloxacin, Rhone DPC Europe, Paris, France; grepafloxacin, GlaxoWellcome, Uxbridge, United Kingdom; gatifloxacin, Grunenthal GmBH, Aachen,Germany; clinafloxacin, Parke-Davis Warner Lambert, Somerville, N.J.; levofloxacin, Hoechst Marion Roussel, Strasbourg, France; sitafloxacin, Daiichi, Tokyo, Japan; norfloxacin, tetracycline, chloramphenicol, and acriflavine, Sigma, St. Louis, Mo.

    Techniques:

    Accumulation of fluoroquinolones by S. pneumoniae M4 and M22. Light gray bars, fluoroquinolone alone; black bars, fluoroquinolone plus reserpine. Grepa, grepafloxacin; Cip, ciprofloxacin; Nor, norfloxacin; Oflox, ofloxacin; Levo, levofloxacin; Moxi, moxifloxacin; Gati, gatifloxacin; Clina, clinafloxacin; Sita, sitafloxacin. Mean values ± standard deviations are shown.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Accumulation of 10 Fluoroquinolones by Wild-Type or Efflux Mutant Streptococcus pneumoniae

    doi: 10.1128/AAC.46.3.813-820.2002

    Figure Lengend Snippet: Accumulation of fluoroquinolones by S. pneumoniae M4 and M22. Light gray bars, fluoroquinolone alone; black bars, fluoroquinolone plus reserpine. Grepa, grepafloxacin; Cip, ciprofloxacin; Nor, norfloxacin; Oflox, ofloxacin; Levo, levofloxacin; Moxi, moxifloxacin; Gati, gatifloxacin; Clina, clinafloxacin; Sita, sitafloxacin. Mean values ± standard deviations are shown.

    Article Snippet: All antibiotics were gifts and were made up and used according to the manufacturers' instructions: ciprofloxacin and moxifloxacin, Bayer AG, Leverkusen, Germany; sparfloxacin, Rhone DPC Europe, Paris, France; grepafloxacin, GlaxoWellcome, Uxbridge, United Kingdom; gatifloxacin, Grunenthal GmBH, Aachen,Germany; clinafloxacin, Parke-Davis Warner Lambert, Somerville, N.J.; levofloxacin, Hoechst Marion Roussel, Strasbourg, France; sitafloxacin, Daiichi, Tokyo, Japan; norfloxacin, tetracycline, chloramphenicol, and acriflavine, Sigma, St. Louis, Mo.

    Techniques:

    Gain or loss in sensitivity and specificity for the detection of affected liver segments for gadoxetate disodium (post [20 min]-pre) vs gadobenate dimeglumine (post [40 min]-pre), difference (%), bars indicate 95% confidence intervals. *Indicates statistical significance. HCC indicates hepatocellular carcinoma.

    Journal: Magnetic Resonance Insights

    Article Title: Diagnostic Efficacy and Safety of Gadoxetate Disodium vs Gadobenate Dimeglumine in Patients With Known or Suspected Focal Liver Lesions: Results of a Clinical Phase III Study

    doi: 10.1177/1178623X19827976

    Figure Lengend Snippet: Gain or loss in sensitivity and specificity for the detection of affected liver segments for gadoxetate disodium (post [20 min]-pre) vs gadobenate dimeglumine (post [40 min]-pre), difference (%), bars indicate 95% confidence intervals. *Indicates statistical significance. HCC indicates hepatocellular carcinoma.

    Article Snippet: Gadoxetate disodium consistently increased sensitivity from pre-contrast to post-contrast imaging in all 4 patient groups by 6.2% to 9.9%, while for gadobenate dimeglumine, the range of change was −2.9% to 10.0% ( ).

    Techniques:

    Combination of poly-ICLC and Sorafenib enhanced tumor control in NSG mice NSG mice were transplanted with Hepa 1-6 cells and PBS or poly-ICLC (pIC) were treated as indicated in Figure 2A . A. Slowed tumor growth on d10, pIC+S: 39.7 ± 13.8 mm 2 vs. PBS: 75.3 ± 34.1 mm 2 , p = 0.02; on d14 pIC+S: 88.8 ± 42.6 mm 2 vs. PBS: 155.0 ± 31.1 mm 2 , p

    Journal: Oncotarget

    Article Title: TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

    doi:

    Figure Lengend Snippet: Combination of poly-ICLC and Sorafenib enhanced tumor control in NSG mice NSG mice were transplanted with Hepa 1-6 cells and PBS or poly-ICLC (pIC) were treated as indicated in Figure 2A . A. Slowed tumor growth on d10, pIC+S: 39.7 ± 13.8 mm 2 vs. PBS: 75.3 ± 34.1 mm 2 , p = 0.02; on d14 pIC+S: 88.8 ± 42.6 mm 2 vs. PBS: 155.0 ± 31.1 mm 2 , p

    Article Snippet: Sorafenib or Nexavar® 200 mg film-coated tablets were purchased from Bayer AG and was used at 60 μg/g of Harlan diet.

    Techniques: Mouse Assay

    Combination of poly-ICLC and Sorafenib enhanced tumor control in mice C57BL/6 mice were transplanted with Hepa 1-6 cells and PBS or poly-ICLC (pIC) were given on the indicated days (arrows) and Sorafenib (S) was included in the diet. A B. Treatment started on day 1. n = 8–9 each group. A. Slowed tumor growth on d14, pIC+S: 12.8 ± 6.8 mm 2 vs. PBS: 52.0 ± 23.5 mm 2 , p

    Journal: Oncotarget

    Article Title: TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

    doi:

    Figure Lengend Snippet: Combination of poly-ICLC and Sorafenib enhanced tumor control in mice C57BL/6 mice were transplanted with Hepa 1-6 cells and PBS or poly-ICLC (pIC) were given on the indicated days (arrows) and Sorafenib (S) was included in the diet. A B. Treatment started on day 1. n = 8–9 each group. A. Slowed tumor growth on d14, pIC+S: 12.8 ± 6.8 mm 2 vs. PBS: 52.0 ± 23.5 mm 2 , p

    Article Snippet: Sorafenib or Nexavar® 200 mg film-coated tablets were purchased from Bayer AG and was used at 60 μg/g of Harlan diet.

    Techniques: Mouse Assay

    Co-treatment with poly-ICLC and Sorafenib impairs tumor cell survival and proliferation Hepa 1-6 cells were either treated with vehicle (Ctl), poly-ICLC (pIC), Sorafenib (S) or a combination of both (pIC+S) at 37°C. A. Enhanced cell death was observed as an increased percentage of Annexin-V + Topro-3 + cells after 48 h treatment with pIC+S: 59.5 ± 4.6% vs. Ctl: 29.1 ± 7.3%, p = 0.004, and vs. S: 34.4 ± 7.1%, p = 0.01. Right, representative dot plots showing increased Annexin-V + Topro-3 + population among Hepa 1-6 cells treated with pIC+S. B. Representative light microscopy images of Hepa 1-6 cells in culture showing enhanced cell death after pIC+S treatment for 48 h (100× magnification). C. Inhibition of Hepa 1-6 cell proliferation as measured by thymidine incorporation (Log) at 24 h after treatment with pIC+S: 3.4 ± 0.1 vs. Ctl: 4.8 ± 0.5, p = 0.03 and vs. pIC: 4.9 ± 0.2, p = 0.005. D. Enhanced cell death and E. inhibition of cell proliferation were observed in SNU449 and SNU475 cells after treatment with pIC+S. For all graphs, mean and SD were shown. * p

    Journal: Oncotarget

    Article Title: TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

    doi:

    Figure Lengend Snippet: Co-treatment with poly-ICLC and Sorafenib impairs tumor cell survival and proliferation Hepa 1-6 cells were either treated with vehicle (Ctl), poly-ICLC (pIC), Sorafenib (S) or a combination of both (pIC+S) at 37°C. A. Enhanced cell death was observed as an increased percentage of Annexin-V + Topro-3 + cells after 48 h treatment with pIC+S: 59.5 ± 4.6% vs. Ctl: 29.1 ± 7.3%, p = 0.004, and vs. S: 34.4 ± 7.1%, p = 0.01. Right, representative dot plots showing increased Annexin-V + Topro-3 + population among Hepa 1-6 cells treated with pIC+S. B. Representative light microscopy images of Hepa 1-6 cells in culture showing enhanced cell death after pIC+S treatment for 48 h (100× magnification). C. Inhibition of Hepa 1-6 cell proliferation as measured by thymidine incorporation (Log) at 24 h after treatment with pIC+S: 3.4 ± 0.1 vs. Ctl: 4.8 ± 0.5, p = 0.03 and vs. pIC: 4.9 ± 0.2, p = 0.005. D. Enhanced cell death and E. inhibition of cell proliferation were observed in SNU449 and SNU475 cells after treatment with pIC+S. For all graphs, mean and SD were shown. * p

    Article Snippet: Sorafenib or Nexavar® 200 mg film-coated tablets were purchased from Bayer AG and was used at 60 μg/g of Harlan diet.

    Techniques: CTL Assay, Light Microscopy, Inhibition

    Co-treatment with Sorafenib and poly-ICLC impairs phosphorylation of AKT, MEK and ERK in Hepa 1-6 cells Hepa 1-6 cells were treated with vehicle (Ctl), poly-ICLC (pIC), Sorafenib (S) or combination of both (pIC+S) at 37°C. A. Inhibition of pAKT, pMEK and pERK in cells 24 h post-treatment was revealed by densitometry measurement of phospho-protein expression relative to total protein levels. Graphs show the relative fold-change of the various treatments relative to Ctl. B. Representative Western blot images showing expression of phosphorylated proteins with respect to total protein levels and expression of the housekeeping protein GAPDH. C. Reduced relative gene expression of BIRC5 with respect to the housekeeping gene GAPDH, as assessed by quantitative-PCR in cells treated with pIC+S for 8 h. For all graphs, mean and SD are shown. ** p

    Journal: Oncotarget

    Article Title: TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

    doi:

    Figure Lengend Snippet: Co-treatment with Sorafenib and poly-ICLC impairs phosphorylation of AKT, MEK and ERK in Hepa 1-6 cells Hepa 1-6 cells were treated with vehicle (Ctl), poly-ICLC (pIC), Sorafenib (S) or combination of both (pIC+S) at 37°C. A. Inhibition of pAKT, pMEK and pERK in cells 24 h post-treatment was revealed by densitometry measurement of phospho-protein expression relative to total protein levels. Graphs show the relative fold-change of the various treatments relative to Ctl. B. Representative Western blot images showing expression of phosphorylated proteins with respect to total protein levels and expression of the housekeeping protein GAPDH. C. Reduced relative gene expression of BIRC5 with respect to the housekeeping gene GAPDH, as assessed by quantitative-PCR in cells treated with pIC+S for 8 h. For all graphs, mean and SD are shown. ** p

    Article Snippet: Sorafenib or Nexavar® 200 mg film-coated tablets were purchased from Bayer AG and was used at 60 μg/g of Harlan diet.

    Techniques: CTL Assay, Inhibition, Expressing, Western Blot, Real-time Polymerase Chain Reaction

    Tumor immunogenicity is enhanced by combinatorial treatment with poly-ICLC and Sorafenib C57BL/6 mice were transplanted with Hepa 1-6 cells and treated as indicated in Figure 2C . Reduced percentage of A. PD-1 + CD8 + T cells in mice treated with pIC+S: 53.7 ± 19.9% vs. PBS: 82.3 ± 7.3%, p = 0.0003, and vs. pIC: 75.7 ± 13.4%, p = 0.0062 and B. PD-L1 + CD45 − tumor cells in mice treated with pIC+S: 5.4 ± 2.9% vs. PBS: 12.7 ± 5.4%, p = 0.005. C. Left, Graph shows reduced median fluorescence intensity (MFI) levels of PD-1 expression on PD-1 + CD8 + T cells isolated from tumors in mice treated with pIC+S: 1202 ± 557 vs. PBS: 2284 ± 411, p

    Journal: Oncotarget

    Article Title: TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

    doi:

    Figure Lengend Snippet: Tumor immunogenicity is enhanced by combinatorial treatment with poly-ICLC and Sorafenib C57BL/6 mice were transplanted with Hepa 1-6 cells and treated as indicated in Figure 2C . Reduced percentage of A. PD-1 + CD8 + T cells in mice treated with pIC+S: 53.7 ± 19.9% vs. PBS: 82.3 ± 7.3%, p = 0.0003, and vs. pIC: 75.7 ± 13.4%, p = 0.0062 and B. PD-L1 + CD45 − tumor cells in mice treated with pIC+S: 5.4 ± 2.9% vs. PBS: 12.7 ± 5.4%, p = 0.005. C. Left, Graph shows reduced median fluorescence intensity (MFI) levels of PD-1 expression on PD-1 + CD8 + T cells isolated from tumors in mice treated with pIC+S: 1202 ± 557 vs. PBS: 2284 ± 411, p

    Article Snippet: Sorafenib or Nexavar® 200 mg film-coated tablets were purchased from Bayer AG and was used at 60 μg/g of Harlan diet.

    Techniques: Mouse Assay, Fluorescence, Expressing, Isolation

    The effect of JNJ-Q2 (p.o., squares), ciprofloxacin (i.p., triangles), and moxifloxacin (p.o., circles) on established MRSA ATCC 43300 skin infections. Each symbol represents the mean ± standard error for 14 to 16 mice. The starting inoculum was

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Efficacy of a New Fluoroquinolone, JNJ-Q2, in Murine Models of Staphylococcus aureus and Streptococcus pneumoniae Skin, Respiratory, and Systemic Infections

    doi: 10.1128/AAC.00471-11

    Figure Lengend Snippet: The effect of JNJ-Q2 (p.o., squares), ciprofloxacin (i.p., triangles), and moxifloxacin (p.o., circles) on established MRSA ATCC 43300 skin infections. Each symbol represents the mean ± standard error for 14 to 16 mice. The starting inoculum was

    Article Snippet: Moxifloxacin was obtained from Bayer AG, gemifloxacin from CB Research and Development, Inc. (New Castle, DE), and linezolid from Organix, Inc. (Wolburn, MA).

    Techniques: Mouse Assay

    The effect of JNJ-Q2 (p.o., squares), ciprofloxacin (i.p., triangles), and moxifloxacin (p.o., circles) on lesion volume in mice with established MRSA ATCC 43300 skin infections. Each symbol represents the mean ± standard error for 14 to 16 mice.

    Journal: Antimicrobial Agents and Chemotherapy

    Article Title: Efficacy of a New Fluoroquinolone, JNJ-Q2, in Murine Models of Staphylococcus aureus and Streptococcus pneumoniae Skin, Respiratory, and Systemic Infections

    doi: 10.1128/AAC.00471-11

    Figure Lengend Snippet: The effect of JNJ-Q2 (p.o., squares), ciprofloxacin (i.p., triangles), and moxifloxacin (p.o., circles) on lesion volume in mice with established MRSA ATCC 43300 skin infections. Each symbol represents the mean ± standard error for 14 to 16 mice.

    Article Snippet: Moxifloxacin was obtained from Bayer AG, gemifloxacin from CB Research and Development, Inc. (New Castle, DE), and linezolid from Organix, Inc. (Wolburn, MA).

    Techniques: Mouse Assay

    In vitro antibacterial activity of enrofloxacin against Escherichia coli in MHB .

    Journal: Frontiers in Microbiology

    Article Title: Pharmacokinetic and Pharmacodynamic Integration and Modeling of Enrofloxacin in Swine for Escherichia coli

    doi: 10.3389/fmicb.2016.00036

    Figure Lengend Snippet: In vitro antibacterial activity of enrofloxacin against Escherichia coli in MHB .

    Article Snippet: Drug administration The 50 mg/mL enrofloxacin solution purchased from Baytril (Bayer AG, Leverkussen, Danmark).

    Techniques: In Vitro, Activity Assay

    Enrofloxacin concentration-time profiles plotted for plasma, ileum content after IM administration . Values are mean ± SD ( n = 6).

    Journal: Frontiers in Microbiology

    Article Title: Pharmacokinetic and Pharmacodynamic Integration and Modeling of Enrofloxacin in Swine for Escherichia coli

    doi: 10.3389/fmicb.2016.00036

    Figure Lengend Snippet: Enrofloxacin concentration-time profiles plotted for plasma, ileum content after IM administration . Values are mean ± SD ( n = 6).

    Article Snippet: Drug administration The 50 mg/mL enrofloxacin solution purchased from Baytril (Bayer AG, Leverkussen, Danmark).

    Techniques: Concentration Assay

    Ex vivo antibacterial activity of enrofloxacin in ileum content of swine against Escherichia coli after intramuscular administration ( n = 6) .

    Journal: Frontiers in Microbiology

    Article Title: Pharmacokinetic and Pharmacodynamic Integration and Modeling of Enrofloxacin in Swine for Escherichia coli

    doi: 10.3389/fmicb.2016.00036

    Figure Lengend Snippet: Ex vivo antibacterial activity of enrofloxacin in ileum content of swine against Escherichia coli after intramuscular administration ( n = 6) .

    Article Snippet: Drug administration The 50 mg/mL enrofloxacin solution purchased from Baytril (Bayer AG, Leverkussen, Danmark).

    Techniques: Ex Vivo, Activity Assay

    Contrast agent uptake in the inguinal lymph nodes. ( a ) The uptake of Gd-DTPA into the LIN and RIN (arrows) is shown in single slice examples. Gd-DTPA uptake is minimally detected in the RIN, and not in the LIN. ( b ) Gd-LNP is taken up into the RIN but not into the LIN. ( c ) Gd-FVT contrast agent accumulates in the RIN and LIN, at 5 and at 15 min after injection. Scale bars are indicated.

    Journal: Scientific Reports

    Article Title: Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles

    doi: 10.1038/srep15641

    Figure Lengend Snippet: Contrast agent uptake in the inguinal lymph nodes. ( a ) The uptake of Gd-DTPA into the LIN and RIN (arrows) is shown in single slice examples. Gd-DTPA uptake is minimally detected in the RIN, and not in the LIN. ( b ) Gd-LNP is taken up into the RIN but not into the LIN. ( c ) Gd-FVT contrast agent accumulates in the RIN and LIN, at 5 and at 15 min after injection. Scale bars are indicated.

    Article Snippet: The dorsal toes of both rear feet were injected subcutaneously with 25 μl of Gd-DTPA (Magnevist; 0.025 mmol/kg; Bayer Pharmaceuticals, Wayne, NJ, USA), Gd-FVT (0.025 mmol/kg; Ablavar: Lantheus Medical Imaging; N. Billerica, MA, USA) or Gd-LNP (0.01 mmol/kg), in sterile HBSS (Invitrogen, Grand Island, NY, USA).

    Techniques: Injection

    Quantitation of contrast agent uptake in tumor-draining and uninvolved popliteal lymph nodes. Integrated density values over each popliteal LN were calculated using the 90 th percentile threshold method. Change from pre-contrast integrated density is summarized for groups of 6 mice receiving each contrast agent, with standard error bars displayed at each timepoint. ( a ) The integrated density of Gd-DTPA contrast uptake into ROIs increases within 5 min after injection in the LPN ( # p = 0.01) and RPN ( # p = 0.006), as estimated in a linear mixed effects regression model. ( b ) The integrated density of Gd-LNP contrast uptake increases within 5 min after injection for the tumor-draining LPN ( # p = 0.009), but not for the RPN (p = 0.24). Moreover, the contrast uptake into the LPN is significantly higher than into the RPN at both 5 and 15 min after injection (*p

    Journal: Scientific Reports

    Article Title: Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles

    doi: 10.1038/srep15641

    Figure Lengend Snippet: Quantitation of contrast agent uptake in tumor-draining and uninvolved popliteal lymph nodes. Integrated density values over each popliteal LN were calculated using the 90 th percentile threshold method. Change from pre-contrast integrated density is summarized for groups of 6 mice receiving each contrast agent, with standard error bars displayed at each timepoint. ( a ) The integrated density of Gd-DTPA contrast uptake into ROIs increases within 5 min after injection in the LPN ( # p = 0.01) and RPN ( # p = 0.006), as estimated in a linear mixed effects regression model. ( b ) The integrated density of Gd-LNP contrast uptake increases within 5 min after injection for the tumor-draining LPN ( # p = 0.009), but not for the RPN (p = 0.24). Moreover, the contrast uptake into the LPN is significantly higher than into the RPN at both 5 and 15 min after injection (*p

    Article Snippet: The dorsal toes of both rear feet were injected subcutaneously with 25 μl of Gd-DTPA (Magnevist; 0.025 mmol/kg; Bayer Pharmaceuticals, Wayne, NJ, USA), Gd-FVT (0.025 mmol/kg; Ablavar: Lantheus Medical Imaging; N. Billerica, MA, USA) or Gd-LNP (0.01 mmol/kg), in sterile HBSS (Invitrogen, Grand Island, NY, USA).

    Techniques: Quantitation Assay, Mouse Assay, Injection

    Quantitation of contrast agent uptake in inguinal lymph nodes. Integrated density values in each inguinal LN were calculated using the 90 th percentile threshold method. Change from pre-contrast integrated density is summarized for groups of 6 mice receiving each contrast agent, with standard error bars displayed at each timepoint. ( a ) Gd-DPTA uptake into the RIN appears to be greater than into the LIN at 5 min after injection (p = 0.07) and at 15 min after injection (*p = 0.009). ( b ) Gd-LNP also accumulates in the RIN more than the LIN at 5 min after injection (*p = 0.01) and at 15 min after injection (*p = 0.03). ( c ) Similar trends were seen for Gd-FVT, with contrast uptake greater into the RIN than into the LIN at 5 min after injection (p = 0.11) and at 15 min (*p = 0.04). In most cases the integrated density of contrast uptake was not found to increase within 5 min after injection (p > 0.05 in linear mixed effects model), with the exception of the RIN for Gd-DTPA (average 213,000 increase, # p = 0.002) and RIN for Gd-FVT (average 913,000 increase, # p = 0.02).

    Journal: Scientific Reports

    Article Title: Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles

    doi: 10.1038/srep15641

    Figure Lengend Snippet: Quantitation of contrast agent uptake in inguinal lymph nodes. Integrated density values in each inguinal LN were calculated using the 90 th percentile threshold method. Change from pre-contrast integrated density is summarized for groups of 6 mice receiving each contrast agent, with standard error bars displayed at each timepoint. ( a ) Gd-DPTA uptake into the RIN appears to be greater than into the LIN at 5 min after injection (p = 0.07) and at 15 min after injection (*p = 0.009). ( b ) Gd-LNP also accumulates in the RIN more than the LIN at 5 min after injection (*p = 0.01) and at 15 min after injection (*p = 0.03). ( c ) Similar trends were seen for Gd-FVT, with contrast uptake greater into the RIN than into the LIN at 5 min after injection (p = 0.11) and at 15 min (*p = 0.04). In most cases the integrated density of contrast uptake was not found to increase within 5 min after injection (p > 0.05 in linear mixed effects model), with the exception of the RIN for Gd-DTPA (average 213,000 increase, # p = 0.002) and RIN for Gd-FVT (average 913,000 increase, # p = 0.02).

    Article Snippet: The dorsal toes of both rear feet were injected subcutaneously with 25 μl of Gd-DTPA (Magnevist; 0.025 mmol/kg; Bayer Pharmaceuticals, Wayne, NJ, USA), Gd-FVT (0.025 mmol/kg; Ablavar: Lantheus Medical Imaging; N. Billerica, MA, USA) or Gd-LNP (0.01 mmol/kg), in sterile HBSS (Invitrogen, Grand Island, NY, USA).

    Techniques: Quantitation Assay, Mouse Assay, Injection

    Gd-LNP contrast media detects increased lymph drainage through the tumor-draining popliteal lymph node. ( a ) Full field-of-view oblique MIP image, illustrating the in vivo locations of the left and right popliteal (LPN and RPN, respectively) and inguinal LNs (LIN and RIN) that were analyzed in the study. The MIP was generated from 5 min post- GD-LNP images, in the same animal shown in part c. ( b ) Representative single slice images of LPN and RPN (arrows) from pre-contrast (0 min) and from 5 and 15 minute post-contrast scans after Gd-DTPA injection demonstrate modest LN enhancement after contrast injection. The orientation of the cortex and medulla is indicated. Arrowhead indicates the dark artifacts arising after contrast agent injection. ( c ) Single slice images of popliteal LNs after Gd-LNP injection show higher uptake into the LPN at 5 and 15 min. ( d ) Single slice images of popliteal LNs after Gd-FVT injection show uptake into the LPN and RPN at 5 min after contrast agent injection. Scale bars are indicated.

    Journal: Scientific Reports

    Article Title: Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles

    doi: 10.1038/srep15641

    Figure Lengend Snippet: Gd-LNP contrast media detects increased lymph drainage through the tumor-draining popliteal lymph node. ( a ) Full field-of-view oblique MIP image, illustrating the in vivo locations of the left and right popliteal (LPN and RPN, respectively) and inguinal LNs (LIN and RIN) that were analyzed in the study. The MIP was generated from 5 min post- GD-LNP images, in the same animal shown in part c. ( b ) Representative single slice images of LPN and RPN (arrows) from pre-contrast (0 min) and from 5 and 15 minute post-contrast scans after Gd-DTPA injection demonstrate modest LN enhancement after contrast injection. The orientation of the cortex and medulla is indicated. Arrowhead indicates the dark artifacts arising after contrast agent injection. ( c ) Single slice images of popliteal LNs after Gd-LNP injection show higher uptake into the LPN at 5 and 15 min. ( d ) Single slice images of popliteal LNs after Gd-FVT injection show uptake into the LPN and RPN at 5 min after contrast agent injection. Scale bars are indicated.

    Article Snippet: The dorsal toes of both rear feet were injected subcutaneously with 25 μl of Gd-DTPA (Magnevist; 0.025 mmol/kg; Bayer Pharmaceuticals, Wayne, NJ, USA), Gd-FVT (0.025 mmol/kg; Ablavar: Lantheus Medical Imaging; N. Billerica, MA, USA) or Gd-LNP (0.01 mmol/kg), in sterile HBSS (Invitrogen, Grand Island, NY, USA).

    Techniques: In Vivo, Generated, Injection

    Histological sections of C . radiatus midgut stained with hematoxylin and eosin. ( A-C ): control treatment with no exposure to insecticide. ( D-F ): 1h exposure to deltamethrin. ( G-I ): 12 h exposure to deltamethrin. ( J-L ): 24 h exposure to deltamethrin. All exposure time were performed for the lowest deltamethrin concentration (0.25 μg of a.i/L) used in this study. lm : midgut lumen, pm : peritrophic membrane, nu : nuclei, ml : muscle layer, va : vacuolation, arrows : basophilic granules.

    Journal: PLoS ONE

    Article Title: Deltamethrin-Mediated Toxicity and Cytomorphological Changes in the Midgut and Nervous System of the Mayfly Callibaetis radiatus

    doi: 10.1371/journal.pone.0152383

    Figure Lengend Snippet: Histological sections of C . radiatus midgut stained with hematoxylin and eosin. ( A-C ): control treatment with no exposure to insecticide. ( D-F ): 1h exposure to deltamethrin. ( G-I ): 12 h exposure to deltamethrin. ( J-L ): 24 h exposure to deltamethrin. All exposure time were performed for the lowest deltamethrin concentration (0.25 μg of a.i/L) used in this study. lm : midgut lumen, pm : peritrophic membrane, nu : nuclei, ml : muscle layer, va : vacuolation, arrows : basophilic granules.

    Article Snippet: Midgut The midgut of C . radiatus nymphs not exposed to deltamethrin showed a single-layered epithelium of columnar digestive cells and some scattered nests of regenerative cells ( ).

    Techniques: Staining, Concentration Assay

    Deltamethrin-mediated changes in the survival abilities of C . radiatus . ( A ) Survival curves of C . radiatus nymphs subjected to up to 96 h deltamethrin exposure. Only the survival curves of the highest concentrations (2.5 and 5 μg of a.i/L) were not significantly different by Holm-Sidak’s test ( P > 0.05). Points represent the censored data (nymphs surviving until the end of the experiment, as well as the emerged adults). ( B ) Mean lifetime of C . radiatus nymphs under 96 h deltamethrin exposure. Dispersion expressed as SE.

    Journal: PLoS ONE

    Article Title: Deltamethrin-Mediated Toxicity and Cytomorphological Changes in the Midgut and Nervous System of the Mayfly Callibaetis radiatus

    doi: 10.1371/journal.pone.0152383

    Figure Lengend Snippet: Deltamethrin-mediated changes in the survival abilities of C . radiatus . ( A ) Survival curves of C . radiatus nymphs subjected to up to 96 h deltamethrin exposure. Only the survival curves of the highest concentrations (2.5 and 5 μg of a.i/L) were not significantly different by Holm-Sidak’s test ( P > 0.05). Points represent the censored data (nymphs surviving until the end of the experiment, as well as the emerged adults). ( B ) Mean lifetime of C . radiatus nymphs under 96 h deltamethrin exposure. Dispersion expressed as SE.

    Article Snippet: Midgut The midgut of C . radiatus nymphs not exposed to deltamethrin showed a single-layered epithelium of columnar digestive cells and some scattered nests of regenerative cells ( ).

    Techniques:

    Histological sections of C . radiatus thoracic ganglia stained with hematoxylin and eosin. ( A and E ), Control treatment with no exposure to insecticide. ( B and F ), 1h exposure to deltamethsurin. ( C and G ), 12 h exposure to deltamethrin. ( D and H ), 24 h exposure to deltamethrin. All exposure time were performed for the lowest deltamethrin concentration used in this study (0.25 μg of a.i/L). ne : neuropile; cb : cell body of neuron; arrow : pyknotic nucleus

    Journal: PLoS ONE

    Article Title: Deltamethrin-Mediated Toxicity and Cytomorphological Changes in the Midgut and Nervous System of the Mayfly Callibaetis radiatus

    doi: 10.1371/journal.pone.0152383

    Figure Lengend Snippet: Histological sections of C . radiatus thoracic ganglia stained with hematoxylin and eosin. ( A and E ), Control treatment with no exposure to insecticide. ( B and F ), 1h exposure to deltamethsurin. ( C and G ), 12 h exposure to deltamethrin. ( D and H ), 24 h exposure to deltamethrin. All exposure time were performed for the lowest deltamethrin concentration used in this study (0.25 μg of a.i/L). ne : neuropile; cb : cell body of neuron; arrow : pyknotic nucleus

    Article Snippet: Midgut The midgut of C . radiatus nymphs not exposed to deltamethrin showed a single-layered epithelium of columnar digestive cells and some scattered nests of regenerative cells ( ).

    Techniques: Staining, Concentration Assay

    Histological sections of C . radiatus brain stained with hematoxylin and eosin. ( A ), Whole brain section. ( B ), Control treatment with no exposure to insecticide. ( C ), 1 h exposure to deltamethrin. ( D ), 12 h exposure to deltamethrin. ( E ), 24 h exposure to deltamethrin. All exposure times were performed for the lowest deltamethrin concentration used in this study (0.25 μg of a.i/L). ne : neuropile; cb : cell body of neuron; arrow : pyknotic nucleus; mu : muscles.

    Journal: PLoS ONE

    Article Title: Deltamethrin-Mediated Toxicity and Cytomorphological Changes in the Midgut and Nervous System of the Mayfly Callibaetis radiatus

    doi: 10.1371/journal.pone.0152383

    Figure Lengend Snippet: Histological sections of C . radiatus brain stained with hematoxylin and eosin. ( A ), Whole brain section. ( B ), Control treatment with no exposure to insecticide. ( C ), 1 h exposure to deltamethrin. ( D ), 12 h exposure to deltamethrin. ( E ), 24 h exposure to deltamethrin. All exposure times were performed for the lowest deltamethrin concentration used in this study (0.25 μg of a.i/L). ne : neuropile; cb : cell body of neuron; arrow : pyknotic nucleus; mu : muscles.

    Article Snippet: Midgut The midgut of C . radiatus nymphs not exposed to deltamethrin showed a single-layered epithelium of columnar digestive cells and some scattered nests of regenerative cells ( ).

    Techniques: Staining, Concentration Assay

    Attitudes and perceptions towards BETACONNECT in comparison with patients’ current autoinjectors, showing the percentage who scored statements 8, 9, or 10 (where 1 is strongly disagree and 10 is strongly agree). The percentages represent the proportion of patients who selected a rating of 8, 9, or 10 for each statement

    Journal: Neurology and Therapy

    Article Title: Survey of US Patients with Multiple Sclerosis: Comparison of the New Electronic Interferon Beta-1b Autoinjector (BETACONNECT™) With Mechanical Autoinjectors

    doi: 10.1007/s40120-016-0047-3

    Figure Lengend Snippet: Attitudes and perceptions towards BETACONNECT in comparison with patients’ current autoinjectors, showing the percentage who scored statements 8, 9, or 10 (where 1 is strongly disagree and 10 is strongly agree). The percentages represent the proportion of patients who selected a rating of 8, 9, or 10 for each statement

    Article Snippet: The aim of the current survey was to assess patient perceptions of BETACONNECT compared with mechanical autoinjectors using a survey integrated with demonstrations and simulated injections with BETACONNECT.

    Techniques:

    BETACONNECT, Autoject and Rebiject, compared individually against an ideal autoinjector across 18 attributes. Attribute ratings for an ideal autoinjector are also shown ( green bars ). Autoject, Rebiject and BETACONNECT were rated based on how well they performed across the attributes, from 1 (not well) to 10 (very well). For each attribute, the percentage of patients who selected a rating of 8, 9, or 10 for each autoinjector using symbols as shown in the legend. Note: we did not compare Extavia patients separately vs. other groups because there were only two patients using Extavia. The other groups had enough patients for us to analyze and compare them. The two patients using Extavia autoinjectors were included in the total number of 90 patients (all patients following the demonstration and simulated injections with BETACONNECT)

    Journal: Neurology and Therapy

    Article Title: Survey of US Patients with Multiple Sclerosis: Comparison of the New Electronic Interferon Beta-1b Autoinjector (BETACONNECT™) With Mechanical Autoinjectors

    doi: 10.1007/s40120-016-0047-3

    Figure Lengend Snippet: BETACONNECT, Autoject and Rebiject, compared individually against an ideal autoinjector across 18 attributes. Attribute ratings for an ideal autoinjector are also shown ( green bars ). Autoject, Rebiject and BETACONNECT were rated based on how well they performed across the attributes, from 1 (not well) to 10 (very well). For each attribute, the percentage of patients who selected a rating of 8, 9, or 10 for each autoinjector using symbols as shown in the legend. Note: we did not compare Extavia patients separately vs. other groups because there were only two patients using Extavia. The other groups had enough patients for us to analyze and compare them. The two patients using Extavia autoinjectors were included in the total number of 90 patients (all patients following the demonstration and simulated injections with BETACONNECT)

    Article Snippet: The aim of the current survey was to assess patient perceptions of BETACONNECT compared with mechanical autoinjectors using a survey integrated with demonstrations and simulated injections with BETACONNECT.

    Techniques:

    The BETACONNECT autoinjector. Comparator autoinjectors images and details are available from the following websites: Copaxone Autoject/Autoject 2 [ 23 ], Extavia Auto-injector/Auto-injector II [ 24 ], Rebif Rebiject/Rebiject II [ 25 ]. Note: the RebiSmart autoinjector was not included as it has not been approved for use in the US. Pen injector devices such as the Rebif Rebidose were also excluded as they are not autoinjectors

    Journal: Neurology and Therapy

    Article Title: Survey of US Patients with Multiple Sclerosis: Comparison of the New Electronic Interferon Beta-1b Autoinjector (BETACONNECT™) With Mechanical Autoinjectors

    doi: 10.1007/s40120-016-0047-3

    Figure Lengend Snippet: The BETACONNECT autoinjector. Comparator autoinjectors images and details are available from the following websites: Copaxone Autoject/Autoject 2 [ 23 ], Extavia Auto-injector/Auto-injector II [ 24 ], Rebif Rebiject/Rebiject II [ 25 ]. Note: the RebiSmart autoinjector was not included as it has not been approved for use in the US. Pen injector devices such as the Rebif Rebidose were also excluded as they are not autoinjectors

    Article Snippet: The aim of the current survey was to assess patient perceptions of BETACONNECT compared with mechanical autoinjectors using a survey integrated with demonstrations and simulated injections with BETACONNECT.

    Techniques:

    Comparison of injection speed. The full width at half maximum (FWHM) of the time intensity curve is plotted by injection speed in ( a ) (20 ml saline flush) and ( b ) (50 ml saline flush). The maximum signal change ratio (SCR max ) for various injection speeds is shown in ( c ) (20-ml saline flush) and ( d ) (50 ml saline flush). The mean values with 1 standard deviation for the measurements are presented. White markers and dotted regression lines represent the results for gadobutrol, and black markers and solid regression lines represent gadoteridol. Note that the FWHM does not show any statistical difference with the GBCM type, injection speed, or flush volume. However, the SCR max showed a correlation with the injection speed and flush volume. We found a statistically significant difference between the regression line for gadobutrol versus gadoteridol, indicating that gadobutrol had a larger signal drop compared to gadoteridol for both the 20 and 50 ml saline flush.

    Journal: Magnetic Resonance in Medical Sciences

    Article Title: Inter-individual Comparison of Gadobutrol and Gadoteridol Tissue Time-intensity Profiles for Dynamic Susceptibility Contrast Perfusion MR Imaging

    doi: 10.2463/mrms.mp.2017-0172

    Figure Lengend Snippet: Comparison of injection speed. The full width at half maximum (FWHM) of the time intensity curve is plotted by injection speed in ( a ) (20 ml saline flush) and ( b ) (50 ml saline flush). The maximum signal change ratio (SCR max ) for various injection speeds is shown in ( c ) (20-ml saline flush) and ( d ) (50 ml saline flush). The mean values with 1 standard deviation for the measurements are presented. White markers and dotted regression lines represent the results for gadobutrol, and black markers and solid regression lines represent gadoteridol. Note that the FWHM does not show any statistical difference with the GBCM type, injection speed, or flush volume. However, the SCR max showed a correlation with the injection speed and flush volume. We found a statistically significant difference between the regression line for gadobutrol versus gadoteridol, indicating that gadobutrol had a larger signal drop compared to gadoteridol for both the 20 and 50 ml saline flush.

    Article Snippet: The GBCMs used in the current study were gadobutrol (Gd-BT-DO3A, Gadovist gadolinium concentration: 1.0 mol/L; Bayer AG, Leverkusen, Germany) and gadoteridol (Gd-HP-DO3A, ProHance; gadolinium concentration: 0.5 mol/L; Bracco Imaging S.p.A., Milan, Italy).

    Techniques: Injection, Standard Deviation

    Comparison of injection duration. The comparison of injection duration canceled out the difference in concentration between gadobutrol and gadoteridol. The full width at half maximum (FWHM) of the time intensity curve is plotted by injection duration in ( a ) (20 ml saline flush) and ( b ) (50 ml saline flush). The maximum signal change ratio (SCR max ) plotted by injection duration is shown in ( c ) (20 ml saline flush) and ( d ) (50 ml saline flush). White markers and dotted regression lines represent the results for gadobutrol, and black markers and solid regression lines represent gadoteridol. We found no statistically significant difference in the FWHM between gadobutrol and gadoteridol according to injection speed for both the 20 and 50 ml saline flush. The regression line of the SCR max showed a statistically significant ( P

    Journal: Magnetic Resonance in Medical Sciences

    Article Title: Inter-individual Comparison of Gadobutrol and Gadoteridol Tissue Time-intensity Profiles for Dynamic Susceptibility Contrast Perfusion MR Imaging

    doi: 10.2463/mrms.mp.2017-0172

    Figure Lengend Snippet: Comparison of injection duration. The comparison of injection duration canceled out the difference in concentration between gadobutrol and gadoteridol. The full width at half maximum (FWHM) of the time intensity curve is plotted by injection duration in ( a ) (20 ml saline flush) and ( b ) (50 ml saline flush). The maximum signal change ratio (SCR max ) plotted by injection duration is shown in ( c ) (20 ml saline flush) and ( d ) (50 ml saline flush). White markers and dotted regression lines represent the results for gadobutrol, and black markers and solid regression lines represent gadoteridol. We found no statistically significant difference in the FWHM between gadobutrol and gadoteridol according to injection speed for both the 20 and 50 ml saline flush. The regression line of the SCR max showed a statistically significant ( P

    Article Snippet: The GBCMs used in the current study were gadobutrol (Gd-BT-DO3A, Gadovist gadolinium concentration: 1.0 mol/L; Bayer AG, Leverkusen, Germany) and gadoteridol (Gd-HP-DO3A, ProHance; gadolinium concentration: 0.5 mol/L; Bracco Imaging S.p.A., Milan, Italy).

    Techniques: Injection, Concentration Assay

    (A) Reduction in thrombus formation and (B) prolongation of prothrombin time with rivaroxaban in a rabbit arteriovenous shunt model. Each value represents the mean ± SEM of six animals. * p

    Journal: Frontiers in Pharmacology

    Article Title: The discovery of rivaroxaban: translating preclinical assessments into clinical practice

    doi: 10.3389/fphar.2013.00145

    Figure Lengend Snippet: (A) Reduction in thrombus formation and (B) prolongation of prothrombin time with rivaroxaban in a rabbit arteriovenous shunt model. Each value represents the mean ± SEM of six animals. * p

    Article Snippet: In phase I studies in healthy subjects, substrates of CYP3A4 or P-gp (such as the cardiac glycoside digoxin, the statin atorvastatin or the benzodiazepine midazolam) had no clinically relevant effect on the plasma pharmacokinetics of rivaroxaban (Kubitza et al., ; Bayer Pharma AG, ; Mueck et al., ).

    Techniques:

    Aprotinin Inhibits Apoptosis via Mitochondrial Pathway and 250KIU/ml is an Optimal Dose for Protection

    Journal: The Journal of thoracic and cardiovascular surgery

    Article Title: Aprotinin, but not epsilon aminocaproic acid and tranexamic acid, exerts neuroprotection against excitotoxic injury in an in vitro neuronal cell culture model

    doi: 10.1016/j.jtcvs.2013.09.054

    Figure Lengend Snippet: Aprotinin Inhibits Apoptosis via Mitochondrial Pathway and 250KIU/ml is an Optimal Dose for Protection

    Article Snippet: It is likely that aprotinin will be reintroduced into the US through a distributor other than the Bayer Corporation.

    Techniques:

    Aprotinin prevents serum deprivation-induced apoptosis in cortical neurons

    Journal: The Journal of thoracic and cardiovascular surgery

    Article Title: Aprotinin, but not epsilon aminocaproic acid and tranexamic acid, exerts neuroprotection against excitotoxic injury in an in vitro neuronal cell culture model

    doi: 10.1016/j.jtcvs.2013.09.054

    Figure Lengend Snippet: Aprotinin prevents serum deprivation-induced apoptosis in cortical neurons

    Article Snippet: It is likely that aprotinin will be reintroduced into the US through a distributor other than the Bayer Corporation.

    Techniques:

    Aprotinin, but not lysine analogues, are neuroprotective against glutamatergic excitotoxicity

    Journal: The Journal of thoracic and cardiovascular surgery

    Article Title: Aprotinin, but not epsilon aminocaproic acid and tranexamic acid, exerts neuroprotection against excitotoxic injury in an in vitro neuronal cell culture model

    doi: 10.1016/j.jtcvs.2013.09.054

    Figure Lengend Snippet: Aprotinin, but not lysine analogues, are neuroprotective against glutamatergic excitotoxicity

    Article Snippet: It is likely that aprotinin will be reintroduced into the US through a distributor other than the Bayer Corporation.

    Techniques:

    AM overexpression in PaC in vivo leads to the development of glucose intolerance. ( A ) MPanc96 luciferase cells were injected subcutaneously and orthotopically in athymic nude mice (n = 10) and pancreatic tumor was developed. Wild-type mice served as control. By bioluminescence imaging, tumors were size matched, mice were subjected to glucose tolerance tests, and blood glucose levels were measured using a glucometer at different time points. Mice bearing both subcutaneous and orthotopic tumors showed a significant increase ( P

    Journal: Gastroenterology

    Article Title: Adrenomedullin is Up-regulated in Patients With Pancreatic Cancer and Causes Insulin Resistance in β Cells and Mice

    doi: 10.1053/j.gastro.2012.08.044

    Figure Lengend Snippet: AM overexpression in PaC in vivo leads to the development of glucose intolerance. ( A ) MPanc96 luciferase cells were injected subcutaneously and orthotopically in athymic nude mice (n = 10) and pancreatic tumor was developed. Wild-type mice served as control. By bioluminescence imaging, tumors were size matched, mice were subjected to glucose tolerance tests, and blood glucose levels were measured using a glucometer at different time points. Mice bearing both subcutaneous and orthotopic tumors showed a significant increase ( P

    Article Snippet: Blood glucose levels were measured on each mouse using a glucometer (Elite; Bayer Inc, Pittsburgh, PA) before and after the glucose load at different time points (0–150 minutes at 15-minute intervals) every week.

    Techniques: Over Expression, In Vivo, Luciferase, Injection, Mouse Assay, Imaging

    Survival for 14 days of four species of adult lady beetles that were allowed to feed on flowers from Mexican milkweed, Asclepias curassavica , plants that were untreated (C), treated with label rate (1X), or twice label rate (2X) rate of soil-applied imidacloprid (Marathon 1%G). Flowers were presented in opposite ends of a tube cage (C-C, 1X-C, 1X-1X, 2X-C, 2X-2X).

    Journal: PLoS ONE

    Article Title: Soil-Applied Imidacloprid Translocates to Ornamental Flowers and Reduces Survival of Adult Coleomegilla maculata, Harmonia axyridis, and Hippodamia convergens Lady Beetles, and Larval Danaus plexippus and Vanessa cardui Butterflies

    doi: 10.1371/journal.pone.0119133

    Figure Lengend Snippet: Survival for 14 days of four species of adult lady beetles that were allowed to feed on flowers from Mexican milkweed, Asclepias curassavica , plants that were untreated (C), treated with label rate (1X), or twice label rate (2X) rate of soil-applied imidacloprid (Marathon 1%G). Flowers were presented in opposite ends of a tube cage (C-C, 1X-C, 1X-1X, 2X-C, 2X-2X).

    Article Snippet: In ornamental flowering plants grown in greenhouses, a soil application of imidacloprid is 300 mg AI for a 3 gallon (10 L) pot (Marathon 1%G, Olympic Horticultural Products, Mainland, PA; or Bayer Advanced Tree and Shrub, Bayer CropScience, Research Triangle Park, NC).

    Techniques:

    Survival at days 3 and 12 of four species of adult lady beetles that were allowed to feed on flowers from Mexican milkweed, Asclepias curassavica , plants that were untreated (C), treated with label rate (1X), or twice label rate (2X) of soil-applied imidacloprid (Marathon 1%G). Flowers were presented in opposite ends of a tube cage (C-C, 1X-C, 1X-1X, 2X-C, 2X-2X).

    Journal: PLoS ONE

    Article Title: Soil-Applied Imidacloprid Translocates to Ornamental Flowers and Reduces Survival of Adult Coleomegilla maculata, Harmonia axyridis, and Hippodamia convergens Lady Beetles, and Larval Danaus plexippus and Vanessa cardui Butterflies

    doi: 10.1371/journal.pone.0119133

    Figure Lengend Snippet: Survival at days 3 and 12 of four species of adult lady beetles that were allowed to feed on flowers from Mexican milkweed, Asclepias curassavica , plants that were untreated (C), treated with label rate (1X), or twice label rate (2X) of soil-applied imidacloprid (Marathon 1%G). Flowers were presented in opposite ends of a tube cage (C-C, 1X-C, 1X-1X, 2X-C, 2X-2X).

    Article Snippet: In ornamental flowering plants grown in greenhouses, a soil application of imidacloprid is 300 mg AI for a 3 gallon (10 L) pot (Marathon 1%G, Olympic Horticultural Products, Mainland, PA; or Bayer Advanced Tree and Shrub, Bayer CropScience, Research Triangle Park, NC).

    Techniques:

    Survival of two species of adult butterflies that were free-ranging and allowed to feed on flowers from Mexican milkweed, Asclepias curassavica (AC), that were untreated (C), treated with label rate (1X), or twice label rate (2X) of soil-applied imidacloprid (Marathon 1%G) or that were force-fed 30% syrup syrup (S) containing 0 ppb (C), 15 ppb (1X), or 30 ppb (2X) imidacloprid.

    Journal: PLoS ONE

    Article Title: Soil-Applied Imidacloprid Translocates to Ornamental Flowers and Reduces Survival of Adult Coleomegilla maculata, Harmonia axyridis, and Hippodamia convergens Lady Beetles, and Larval Danaus plexippus and Vanessa cardui Butterflies

    doi: 10.1371/journal.pone.0119133

    Figure Lengend Snippet: Survival of two species of adult butterflies that were free-ranging and allowed to feed on flowers from Mexican milkweed, Asclepias curassavica (AC), that were untreated (C), treated with label rate (1X), or twice label rate (2X) of soil-applied imidacloprid (Marathon 1%G) or that were force-fed 30% syrup syrup (S) containing 0 ppb (C), 15 ppb (1X), or 30 ppb (2X) imidacloprid.

    Article Snippet: In ornamental flowering plants grown in greenhouses, a soil application of imidacloprid is 300 mg AI for a 3 gallon (10 L) pot (Marathon 1%G, Olympic Horticultural Products, Mainland, PA; or Bayer Advanced Tree and Shrub, Bayer CropScience, Research Triangle Park, NC).

    Techniques:

    Survival of two species of adult butterflies that were free-ranging and allowed to feed on flowers from Mexican milkweed, Asclepias curassavica , that were untreated (C), treated with label rate (1X), or twice label rate (2X) of soil-applied imidacloprid (Marathon 1%G) for Danaus , monarch butterflies at days 7 and 15 and for Vanessa , painted lady butterflies at days 7, 15, 21, and 29.

    Journal: PLoS ONE

    Article Title: Soil-Applied Imidacloprid Translocates to Ornamental Flowers and Reduces Survival of Adult Coleomegilla maculata, Harmonia axyridis, and Hippodamia convergens Lady Beetles, and Larval Danaus plexippus and Vanessa cardui Butterflies

    doi: 10.1371/journal.pone.0119133

    Figure Lengend Snippet: Survival of two species of adult butterflies that were free-ranging and allowed to feed on flowers from Mexican milkweed, Asclepias curassavica , that were untreated (C), treated with label rate (1X), or twice label rate (2X) of soil-applied imidacloprid (Marathon 1%G) for Danaus , monarch butterflies at days 7 and 15 and for Vanessa , painted lady butterflies at days 7, 15, 21, and 29.

    Article Snippet: In ornamental flowering plants grown in greenhouses, a soil application of imidacloprid is 300 mg AI for a 3 gallon (10 L) pot (Marathon 1%G, Olympic Horticultural Products, Mainland, PA; or Bayer Advanced Tree and Shrub, Bayer CropScience, Research Triangle Park, NC).

    Techniques:

    Survival at days 7, 15, 21, 29 of two species of adult butterflied that were force-fed 30% syrup containing 0 ppb (C), 15 ppb (1X), or 30 ppb (2X) imidacloprid.

    Journal: PLoS ONE

    Article Title: Soil-Applied Imidacloprid Translocates to Ornamental Flowers and Reduces Survival of Adult Coleomegilla maculata, Harmonia axyridis, and Hippodamia convergens Lady Beetles, and Larval Danaus plexippus and Vanessa cardui Butterflies

    doi: 10.1371/journal.pone.0119133

    Figure Lengend Snippet: Survival at days 7, 15, 21, 29 of two species of adult butterflied that were force-fed 30% syrup containing 0 ppb (C), 15 ppb (1X), or 30 ppb (2X) imidacloprid.

    Article Snippet: In ornamental flowering plants grown in greenhouses, a soil application of imidacloprid is 300 mg AI for a 3 gallon (10 L) pot (Marathon 1%G, Olympic Horticultural Products, Mainland, PA; or Bayer Advanced Tree and Shrub, Bayer CropScience, Research Triangle Park, NC).

    Techniques:

    Survival at days 7, 14, and 21 of two species of larval butterflies that were free-ranging on host plants that were untreated (C), treated with label rate (1X), or twice label rate (2X) of soil-applied imidacloprid (Marathon 1%G). Danaus , monarch butterflies were fed Mexican milkweed, Asclepias curassavica , and Vanessa painted lady butterflies were fed globe thistle, Echinops ritro .

    Journal: PLoS ONE

    Article Title: Soil-Applied Imidacloprid Translocates to Ornamental Flowers and Reduces Survival of Adult Coleomegilla maculata, Harmonia axyridis, and Hippodamia convergens Lady Beetles, and Larval Danaus plexippus and Vanessa cardui Butterflies

    doi: 10.1371/journal.pone.0119133

    Figure Lengend Snippet: Survival at days 7, 14, and 21 of two species of larval butterflies that were free-ranging on host plants that were untreated (C), treated with label rate (1X), or twice label rate (2X) of soil-applied imidacloprid (Marathon 1%G). Danaus , monarch butterflies were fed Mexican milkweed, Asclepias curassavica , and Vanessa painted lady butterflies were fed globe thistle, Echinops ritro .

    Article Snippet: In ornamental flowering plants grown in greenhouses, a soil application of imidacloprid is 300 mg AI for a 3 gallon (10 L) pot (Marathon 1%G, Olympic Horticultural Products, Mainland, PA; or Bayer Advanced Tree and Shrub, Bayer CropScience, Research Triangle Park, NC).

    Techniques:

    Percent α-glucosidase inhibition by plant extracts and isolated compound D. Acarbose is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].

    Journal: PLoS ONE

    Article Title: Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

    doi: 10.1371/journal.pone.0106039

    Figure Lengend Snippet: Percent α-glucosidase inhibition by plant extracts and isolated compound D. Acarbose is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].

    Article Snippet: Acarbose was obtained from Bayer Pharmaceuticals Pvt.

    Techniques: Inhibition, Isolation

    Percent crude murine intestinal glucosidase inhibition by plant extracts and isolated compound D. Acarbose is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].

    Journal: PLoS ONE

    Article Title: Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

    doi: 10.1371/journal.pone.0106039

    Figure Lengend Snippet: Percent crude murine intestinal glucosidase inhibition by plant extracts and isolated compound D. Acarbose is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].

    Article Snippet: Acarbose was obtained from Bayer Pharmaceuticals Pvt.

    Techniques: Inhibition, Isolation

    Percent α -amylase inhibition by plant extracts and isolated compound D. Acarbose is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].

    Journal: PLoS ONE

    Article Title: Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

    doi: 10.1371/journal.pone.0106039

    Figure Lengend Snippet: Percent α -amylase inhibition by plant extracts and isolated compound D. Acarbose is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].

    Article Snippet: Acarbose was obtained from Bayer Pharmaceuticals Pvt.

    Techniques: Inhibition, Isolation

    Percent crude murine pancreatic amylase inhibition by plant extracts and isolated compound D. Acarbose is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].

    Journal: PLoS ONE

    Article Title: Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

    doi: 10.1371/journal.pone.0106039

    Figure Lengend Snippet: Percent crude murine pancreatic amylase inhibition by plant extracts and isolated compound D. Acarbose is taken as standard inhibitor. The data is indicated as the mean SEM; [ n = 3].

    Article Snippet: Acarbose was obtained from Bayer Pharmaceuticals Pvt.

    Techniques: Inhibition, Isolation

    Venn diagram displaying the co-associations of chronic kidney disease (CKD), hypertension, and HbA1c.

    Journal: Kidney International Reports

    Article Title: Prevalence of CKD, Diabetes, and Hypertension in Rural Tanzania

    doi: 10.1016/j.ekir.2018.04.006

    Figure Lengend Snippet: Venn diagram displaying the co-associations of chronic kidney disease (CKD), hypertension, and HbA1c.

    Article Snippet: HbA1c was measured at POC with a Bayer A1c Now kit (Bayer Healthcare AG, Leverkusen, BRG).

    Techniques:

    Total bilirubin, AST and ALT plasma levels (mean ±) in the overall population during treatment with regorafenib and silybin

    Journal: Oncotarget

    Article Title: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer

    doi: 10.18632/oncotarget.20054

    Figure Lengend Snippet: Total bilirubin, AST and ALT plasma levels (mean ±) in the overall population during treatment with regorafenib and silybin

    Article Snippet: Regorafenib was kindly provided by Bayer Pharma (Berlin, Germany).

    Techniques: AST Assay

    Effect of regorafenib in combination with silybin on colony formation and on cell metabolism in SW48, SW48-CR, HCT15 and SW480 colon cancer cells lines The SW48, SW48-CR, HCT15 and SW480 cancer cells were treated with silybin (90 μM) or regorafenib (2 μM) and their combination for 72 hours. After 14 days the colonies were stained with 0.1% crystal violet and counted as described in Materials and Methods. ( A ) Images of colon cancer cells acquired by phase-contrast microscope. ( B ) Histogram of colony number counted by image j plugin. Error bars indicate the standard deviation. * p

    Journal: Oncotarget

    Article Title: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer

    doi: 10.18632/oncotarget.20054

    Figure Lengend Snippet: Effect of regorafenib in combination with silybin on colony formation and on cell metabolism in SW48, SW48-CR, HCT15 and SW480 colon cancer cells lines The SW48, SW48-CR, HCT15 and SW480 cancer cells were treated with silybin (90 μM) or regorafenib (2 μM) and their combination for 72 hours. After 14 days the colonies were stained with 0.1% crystal violet and counted as described in Materials and Methods. ( A ) Images of colon cancer cells acquired by phase-contrast microscope. ( B ) Histogram of colony number counted by image j plugin. Error bars indicate the standard deviation. * p

    Article Snippet: Regorafenib was kindly provided by Bayer Pharma (Berlin, Germany).

    Techniques: Staining, Microscopy, Standard Deviation

    Effects of regorafenib in combination with silybin on induction of apoptosis in SW48, SW48-CR, HCT15 and SW480 colon cancer cells ( A ) Apoptosis was evaluated with Annexin-V-FITC staining and 7-Amino-Actinomycin D (7-AAD) detection assays using flow cytometry in SW48, SW48-CR, HCT15 and SW480 cancer cells after 24 hours of incubation with silybin (90 μM) or regorafenib (2 μM) and their combination. Histogram of data expressed as percentage of apoptotic cells.* p

    Journal: Oncotarget

    Article Title: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer

    doi: 10.18632/oncotarget.20054

    Figure Lengend Snippet: Effects of regorafenib in combination with silybin on induction of apoptosis in SW48, SW48-CR, HCT15 and SW480 colon cancer cells ( A ) Apoptosis was evaluated with Annexin-V-FITC staining and 7-Amino-Actinomycin D (7-AAD) detection assays using flow cytometry in SW48, SW48-CR, HCT15 and SW480 cancer cells after 24 hours of incubation with silybin (90 μM) or regorafenib (2 μM) and their combination. Histogram of data expressed as percentage of apoptotic cells.* p

    Article Snippet: Regorafenib was kindly provided by Bayer Pharma (Berlin, Germany).

    Techniques: Staining, Flow Cytometry, Cytometry, Incubation

    Effects of regorafenib in combination with silybin on PI3K/AKT/mTOR intracellular signaling in SW48, SW48-CR, HCT15 and SW480 colon cancer cell lines SW48, SW48-CR, HCT15 and SW480 cancer cells were treated with silybin or regorafenib and their combination at the indicated doses for 24 hours. Total cell protein extracts were subjected to immunoblotting with the indicated antibodies as described in Materials and Methods. α-Tubulin was used as the loading control.

    Journal: Oncotarget

    Article Title: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer

    doi: 10.18632/oncotarget.20054

    Figure Lengend Snippet: Effects of regorafenib in combination with silybin on PI3K/AKT/mTOR intracellular signaling in SW48, SW48-CR, HCT15 and SW480 colon cancer cell lines SW48, SW48-CR, HCT15 and SW480 cancer cells were treated with silybin or regorafenib and their combination at the indicated doses for 24 hours. Total cell protein extracts were subjected to immunoblotting with the indicated antibodies as described in Materials and Methods. α-Tubulin was used as the loading control.

    Article Snippet: Regorafenib was kindly provided by Bayer Pharma (Berlin, Germany).

    Techniques:

    Effects of regorafenib or silybin treatment on cell proliferation in a panel of human colon cancer cell lines ( A–C ) Cells were treated with different concentrations of regorafenib (range, 0.005–2 μM) or silybin (range, 10–100 μM) for 96 hours. The proliferation rate was evaluated by MTT assay, as described in Materials and Methods. (B) The IC 50 value was determined by interpolation with dose-response curves. Results represent the mean of three separate experiments, each performed in duplicate.

    Journal: Oncotarget

    Article Title: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer

    doi: 10.18632/oncotarget.20054

    Figure Lengend Snippet: Effects of regorafenib or silybin treatment on cell proliferation in a panel of human colon cancer cell lines ( A–C ) Cells were treated with different concentrations of regorafenib (range, 0.005–2 μM) or silybin (range, 10–100 μM) for 96 hours. The proliferation rate was evaluated by MTT assay, as described in Materials and Methods. (B) The IC 50 value was determined by interpolation with dose-response curves. Results represent the mean of three separate experiments, each performed in duplicate.

    Article Snippet: Regorafenib was kindly provided by Bayer Pharma (Berlin, Germany).

    Techniques: MTT Assay

    Average baseline signal strength of Resovist ® from Bayer Pharma AG and from I’rom Pharmaceutical Co Ltd. Notes: The first five odd harmonics of the excitation frequency f 0 =25 kHz are shown. There is no statistically significant difference in signal strength at baseline, indicating a similar performance of both products in MPI considering the MPI signal. The noise level of the MPS system is indicated by the dotted gray line. Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.

    Journal: International Journal of Nanomedicine

    Article Title: Magnetic particle imaging: kinetics of the intravascular signal in vivo

    doi: 10.2147/IJN.S49976

    Figure Lengend Snippet: Average baseline signal strength of Resovist ® from Bayer Pharma AG and from I’rom Pharmaceutical Co Ltd. Notes: The first five odd harmonics of the excitation frequency f 0 =25 kHz are shown. There is no statistically significant difference in signal strength at baseline, indicating a similar performance of both products in MPI considering the MPI signal. The noise level of the MPS system is indicated by the dotted gray line. Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.

    Article Snippet: Resovist from I’rom Pharmaceutical Co Ltd performed slightly, albeit not significantly, better than Resovist from Bayer Pharma AG ( ).

    Techniques: Imaging, Spectroscopy

    Average signal strength of a dilution series of Resovist ® from Bayer Pharma AG and from I’rom Pharmaceutical Co Ltd. Notes: The signal strength was measured using MPS. The performance of Resovist from I’rom Pharmaceutical Co Ltd is slightly but not significantly better at higher concentrations. At lower concentrations, no difference can be detected between the two types of Resovist. Abbreviation: MPS, magnetic particle spectroscopy.

    Journal: International Journal of Nanomedicine

    Article Title: Magnetic particle imaging: kinetics of the intravascular signal in vivo

    doi: 10.2147/IJN.S49976

    Figure Lengend Snippet: Average signal strength of a dilution series of Resovist ® from Bayer Pharma AG and from I’rom Pharmaceutical Co Ltd. Notes: The signal strength was measured using MPS. The performance of Resovist from I’rom Pharmaceutical Co Ltd is slightly but not significantly better at higher concentrations. At lower concentrations, no difference can be detected between the two types of Resovist. Abbreviation: MPS, magnetic particle spectroscopy.

    Article Snippet: Resovist from I’rom Pharmaceutical Co Ltd performed slightly, albeit not significantly, better than Resovist from Bayer Pharma AG ( ).

    Techniques: Spectroscopy

    Average strength of the MPI signal in blood as a percentage of the highest blood MPI signal directly after administration of Resovist ® (time, 0 minutes). Notes: The noise level of the MPS system is indicated by the dotted line. The MPI signal of Resovist from I’rom Pharmaceutical Co Ltd decays significantly more rapidly than that of Resovist from Bayer Pharma AG, and drops below the noise level after 15 minutes. Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.

    Journal: International Journal of Nanomedicine

    Article Title: Magnetic particle imaging: kinetics of the intravascular signal in vivo

    doi: 10.2147/IJN.S49976

    Figure Lengend Snippet: Average strength of the MPI signal in blood as a percentage of the highest blood MPI signal directly after administration of Resovist ® (time, 0 minutes). Notes: The noise level of the MPS system is indicated by the dotted line. The MPI signal of Resovist from I’rom Pharmaceutical Co Ltd decays significantly more rapidly than that of Resovist from Bayer Pharma AG, and drops below the noise level after 15 minutes. Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.

    Article Snippet: Resovist from I’rom Pharmaceutical Co Ltd performed slightly, albeit not significantly, better than Resovist from Bayer Pharma AG ( ).

    Techniques: Imaging, Spectroscopy