Journal: Nature Communications

Article Title: Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes

doi: 10.1038/s41467-017-00323-y

Figure Lengend Snippet: Signatures of DNMs and overlap of mutations with ExAC. a The distribution of de novo mutational signatures across all 1152 singleton candidate de novo mutations and 350 that overlap with ExAC. b Differences in context-specific mutation rate. y -axis: significance of the difference in proportion of 5ʹ CCG → CTG 3ʹ DNMs in 1152 mutations from the autozygosity data set (AZ) and 850 DNMs from the 1000 Genomes Project Complete Genomics trio data set (PJL) in comparison with 6948 mutations from the meta-analysis data set ( MDNM ) and variants private to Europeans in the 1000 Genomes Project (EURpriv). The combined p -value shows the result of meta-analysis of the AZ/MDNM and PJL/EURpriv comparisons. A comparison between private mutations in PJL and EUR in the 1000 Genomes Project population data set (PJLpriv) and (EURpriv), respectively is also shown. Significance of the difference in 747 DNMs from the Scottish Family Health Study ( SFHS ) is shown as a control; the size of the disk indicates the fold difference of the test as in the legend. c Proportion of mutations that are 5ʹ CCG → CTG 3ʹ for various whole genome data sets. The AZ data were adjusted for trinucleotide composition differences between exomes and whole genomes. PJLpriv variants show this increased context-specific mutation rate compared to both East Asians (ASNpriv) and Europeans (EURpriv) indicating that the increase is specific to Pakistanis

Article Snippet: We then took the intersection of the final set of autozygous core segments with the Illumina V5 exome bait regions and the 1000 Genomes Project accessibility mask to yield a total evaluated length of 9.46 × 10 9 bp of DNA within the protein-coding regions of the genome.

Techniques: Mutagenesis, Comparison, Control

Journal: The American Journal of Tropical Medicine and Hygiene

Article Title: Evaluation of Community-Directed Operation of Black Fly Traps for Entomological Surveillance of Onchocerca volvulus Transmission in the Madi-Mid North Focus of Onchocerciasis in Northern Uganda

doi: 10.4269/ajtmh.17-0244

Figure Lengend Snippet: Collections from the three traps and human landing collectors in the community of Laminatoo: (A) Daily collections of Simulium damnosum from the trap baited with the BG Sweetscents lure. (B) Daily collections of S. damnosum from the trap baited with the sweat-impregnated socks. (C) Daily collections of S. damnosum from the trap baited with aroma beads. (D) Daily collections of S. damnosum from the HLC team. (E) Collections by all methods overlaid to show concordance among the collections.

Article Snippet: In addition to CO 2 , the individual traps were baited with three different human sweat attractants: 1) sweat-impregnated socks worn by one of the volunteers for 3 days before use; 2) the BG Sweetscents human bait lure (Biogents AG, Regensburg, Germany); and 3) aroma beads saturated with a mixture of human sweat components shown to be attractive to S. damnosum s.l., as previously described.

Techniques:

Journal: The American Journal of Tropical Medicine and Hygiene

Article Title: Evaluation of Community-Directed Operation of Black Fly Traps for Entomological Surveillance of Onchocerca volvulus Transmission in the Madi-Mid North Focus of Onchocerciasis in Northern Uganda

doi: 10.4269/ajtmh.17-0244

Figure Lengend Snippet: Collections from the three traps and human landing collectors in the community of Gonycogo: (A) Daily collections of Simulium damnosum from the trap baited with the BG Sweetscents lure. (B) Daily collections of S. damnosum from the trap baited with the sweat-impregnated socks. (C) Daily collections of S. damnosum from the trap baited with aroma beads. (D) Daily collections of S. damnosum from the HLC team. (E) Collections by all methods overlaid to show concordance among the collections.

Article Snippet: In addition to CO 2 , the individual traps were baited with three different human sweat attractants: 1) sweat-impregnated socks worn by one of the volunteers for 3 days before use; 2) the BG Sweetscents human bait lure (Biogents AG, Regensburg, Germany); and 3) aroma beads saturated with a mixture of human sweat components shown to be attractive to S. damnosum s.l., as previously described.

Techniques: