baicalein Search Results


uuo oa  (MedChemExpress)
93
MedChemExpress uuo oa
Uuo Oa, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bai treatment  (MedChemExpress)
93
MedChemExpress bai treatment
Bai Treatment, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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berberine  (TargetMol)
94
TargetMol berberine
Berberine, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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baicalein  (TargetMol)
93
TargetMol baicalein
( a ) Scatter diagram of inhibition rates’ distribution of 2526 compounds to M pro at 80 μM. The gradient inhibition rates of compounds ( b ) fraxetin, ( c ) vanitiolide, ( d ) (−)–gallocatechin gallate, ( e ) hematoxylin, ( f ) wedelolactone, ( g ) β,β−dimethylacrylalkannin, ( h ) hydroxytyrosol ccetate, ( i ) Cholesterol 3–Sulfate Sodium Salt, ( j ) ginkgolic acid C15:1, ( k ) melanin, and ( l ) <t>baicalein</t> to M pro under two conditions; error bars: mean ± S.D. of three independent replicates.
Baicalein, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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baicalein  (Selleck Chemicals)
94
Selleck Chemicals baicalein
Figure 2 <t>Baicalein</t> can inhibit increased 12-LOX levels in irradiated cells. (A) 12-LOX protein levels decreased in a dose-dependent manner after 24-h baicalein treatment (0, 20, 40, or 80 µmol/L) in Eca109 cells. (B and C) Increased expression of 12-LOX after radiation was inhibited in the baicalein-treated group in Eca109 and Kyse150 cells. Experimental data were obtained from three independent tests.***P < 0.001.
Baicalein, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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baicalein  (ChromaDex)
93
ChromaDex baicalein
Figure 2 <t>Baicalein</t> can inhibit increased 12-LOX levels in irradiated cells. (A) 12-LOX protein levels decreased in a dose-dependent manner after 24-h baicalein treatment (0, 20, 40, or 80 µmol/L) in Eca109 cells. (B and C) Increased expression of 12-LOX after radiation was inhibited in the baicalein-treated group in Eca109 and Kyse150 cells. Experimental data were obtained from three independent tests.***P < 0.001.
Baicalein, supplied by ChromaDex, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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baicalin  (MedChemExpress)
95
MedChemExpress baicalin
Figure 2 <t>Baicalein</t> can inhibit increased 12-LOX levels in irradiated cells. (A) 12-LOX protein levels decreased in a dose-dependent manner after 24-h baicalein treatment (0, 20, 40, or 80 µmol/L) in Eca109 cells. (B and C) Increased expression of 12-LOX after radiation was inhibited in the baicalein-treated group in Eca109 and Kyse150 cells. Experimental data were obtained from three independent tests.***P < 0.001.
Baicalin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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baicalein  (Santa Cruz Biotechnology)
91
Santa Cruz Biotechnology baicalein
Figure 2 <t>Baicalein</t> can inhibit increased 12-LOX levels in irradiated cells. (A) 12-LOX protein levels decreased in a dose-dependent manner after 24-h baicalein treatment (0, 20, 40, or 80 µmol/L) in Eca109 cells. (B and C) Increased expression of 12-LOX after radiation was inhibited in the baicalein-treated group in Eca109 and Kyse150 cells. Experimental data were obtained from three independent tests.***P < 0.001.
Baicalein, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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control baicalin  (ChromaDex)
90
ChromaDex control baicalin
Figure 2 <t>Baicalein</t> can inhibit increased 12-LOX levels in irradiated cells. (A) 12-LOX protein levels decreased in a dose-dependent manner after 24-h baicalein treatment (0, 20, 40, or 80 µmol/L) in Eca109 cells. (B and C) Increased expression of 12-LOX after radiation was inhibited in the baicalein-treated group in Eca109 and Kyse150 cells. Experimental data were obtained from three independent tests.***P < 0.001.
Control Baicalin, supplied by ChromaDex, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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baicalin  (ChromaDex)
86
ChromaDex baicalin
Figure 2 <t>Baicalein</t> can inhibit increased 12-LOX levels in irradiated cells. (A) 12-LOX protein levels decreased in a dose-dependent manner after 24-h baicalein treatment (0, 20, 40, or 80 µmol/L) in Eca109 cells. (B and C) Increased expression of 12-LOX after radiation was inhibited in the baicalein-treated group in Eca109 and Kyse150 cells. Experimental data were obtained from three independent tests.***P < 0.001.
Baicalin, supplied by ChromaDex, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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baicalein  (Chemie GmbH)
90
Chemie GmbH baicalein
Figure 2 <t>Baicalein</t> can inhibit increased 12-LOX levels in irradiated cells. (A) 12-LOX protein levels decreased in a dose-dependent manner after 24-h baicalein treatment (0, 20, 40, or 80 µmol/L) in Eca109 cells. (B and C) Increased expression of 12-LOX after radiation was inhibited in the baicalein-treated group in Eca109 and Kyse150 cells. Experimental data were obtained from three independent tests.***P < 0.001.
Baicalein, supplied by Chemie GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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baicalin  (Dawley Inc)
90
Dawley Inc baicalin
General effects of the analyzed antioxidants on the dopaminergic neurotransmission.
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Image Search Results


( a ) Scatter diagram of inhibition rates’ distribution of 2526 compounds to M pro at 80 μM. The gradient inhibition rates of compounds ( b ) fraxetin, ( c ) vanitiolide, ( d ) (−)–gallocatechin gallate, ( e ) hematoxylin, ( f ) wedelolactone, ( g ) β,β−dimethylacrylalkannin, ( h ) hydroxytyrosol ccetate, ( i ) Cholesterol 3–Sulfate Sodium Salt, ( j ) ginkgolic acid C15:1, ( k ) melanin, and ( l ) baicalein to M pro under two conditions; error bars: mean ± S.D. of three independent replicates.

Journal: Pharmaceuticals

Article Title: Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 M pro

doi: 10.3390/ph16050767

Figure Lengend Snippet: ( a ) Scatter diagram of inhibition rates’ distribution of 2526 compounds to M pro at 80 μM. The gradient inhibition rates of compounds ( b ) fraxetin, ( c ) vanitiolide, ( d ) (−)–gallocatechin gallate, ( e ) hematoxylin, ( f ) wedelolactone, ( g ) β,β−dimethylacrylalkannin, ( h ) hydroxytyrosol ccetate, ( i ) Cholesterol 3–Sulfate Sodium Salt, ( j ) ginkgolic acid C15:1, ( k ) melanin, and ( l ) baicalein to M pro under two conditions; error bars: mean ± S.D. of three independent replicates.

Article Snippet: The Natural Product Library for HTS (catalog number L6000, 50 μL per hole, 10 mM, TargetMol, Shanghai, China, September 2020) was purchased from Shanghai Taosu Biochemical Technology Co., Ltd., including the following: fraxetin (catalog number T2909, TargetMol), vanitiolide (catalog number T0243, TargetMol), (−)–gallocatechin gallate (catalog number T3807, TargetMol), hematoxylin (catalog number T1686, TargetMol), wedelolactone (catalog number T3384, TargetMol), β,β–dimethylacrylalkannin (catalog number T5703, TargetMol), hydroxytyrosol acetate (catalog number T8168, TargetMol), cholesteryl sodium sulfate (catalog number T5239, TargetMol), ginkgolic acid C15:1 (catalog number T6S2123, TargetMol), melanin (catalog number HY-113485, MedChemExpress, Shanghai, China), baicalein (catalog number T2858, TargetMol), sanguinarine (catalog number T2781, TargetMol), corylifol A (catalog number T4S0145, TargetMol), M pro fluorescent substrate (MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2,C223JGC240-1/PE0977, GenScript, Nanjing, China), Sensor Chip SA (10291121, GE Healthcare, Shanghai, China), NHS-PEG12-Biotin (21313, Thermo Scientific, Beijing, China), ultrafiltration centrifuge tube (UFC901096, Millipore), 96-well Microtiter™ microplate (2305-11, Thermo Scientific), black 96-well plate (655077, Greiner Bio-One, Beijing, China), Triton™ X-100 (T109026, Aladdin, Beijing, China), Eppendorf tube (23-2052LK, Crystalgen, Beijing, China).

Techniques: Inhibition

The denaturation profile and the curves of the first derivative of the fluorescence as a function of temperature (−dF/dT) of ( a ) M pro + baicalein, ( b ) M pro + wedelolactone, ( c ) M pro + β,β–dimethylacrylalkannin, ( d ) M pro + cholesteryl sodium sulfate and ( e ) M pro + melanin, the T m value is represented as the highest part of the curve. The K obs for ( f ) baicalein, ( g ) wedelolactone, ( h ) β,β–dimethylacrylalkannin, ( i ) cholesteryl sodium sulfate and ( j ) melanin binding to M pro were derived from plotting ΔT m against log10 of compound concentrations and fitting to linear regression models.

Journal: Pharmaceuticals

Article Title: Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 M pro

doi: 10.3390/ph16050767

Figure Lengend Snippet: The denaturation profile and the curves of the first derivative of the fluorescence as a function of temperature (−dF/dT) of ( a ) M pro + baicalein, ( b ) M pro + wedelolactone, ( c ) M pro + β,β–dimethylacrylalkannin, ( d ) M pro + cholesteryl sodium sulfate and ( e ) M pro + melanin, the T m value is represented as the highest part of the curve. The K obs for ( f ) baicalein, ( g ) wedelolactone, ( h ) β,β–dimethylacrylalkannin, ( i ) cholesteryl sodium sulfate and ( j ) melanin binding to M pro were derived from plotting ΔT m against log10 of compound concentrations and fitting to linear regression models.

Article Snippet: The Natural Product Library for HTS (catalog number L6000, 50 μL per hole, 10 mM, TargetMol, Shanghai, China, September 2020) was purchased from Shanghai Taosu Biochemical Technology Co., Ltd., including the following: fraxetin (catalog number T2909, TargetMol), vanitiolide (catalog number T0243, TargetMol), (−)–gallocatechin gallate (catalog number T3807, TargetMol), hematoxylin (catalog number T1686, TargetMol), wedelolactone (catalog number T3384, TargetMol), β,β–dimethylacrylalkannin (catalog number T5703, TargetMol), hydroxytyrosol acetate (catalog number T8168, TargetMol), cholesteryl sodium sulfate (catalog number T5239, TargetMol), ginkgolic acid C15:1 (catalog number T6S2123, TargetMol), melanin (catalog number HY-113485, MedChemExpress, Shanghai, China), baicalein (catalog number T2858, TargetMol), sanguinarine (catalog number T2781, TargetMol), corylifol A (catalog number T4S0145, TargetMol), M pro fluorescent substrate (MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2,C223JGC240-1/PE0977, GenScript, Nanjing, China), Sensor Chip SA (10291121, GE Healthcare, Shanghai, China), NHS-PEG12-Biotin (21313, Thermo Scientific, Beijing, China), ultrafiltration centrifuge tube (UFC901096, Millipore), 96-well Microtiter™ microplate (2305-11, Thermo Scientific), black 96-well plate (655077, Greiner Bio-One, Beijing, China), Triton™ X-100 (T109026, Aladdin, Beijing, China), Eppendorf tube (23-2052LK, Crystalgen, Beijing, China).

Techniques: Fluorescence, Binding Assay, Derivative Assay

Binding pattern of compounds ( a ) baicalein, ( b ) cholesteryl sodium sulfate, ( c ) ginkgolic acid C15:1, ( d ) wedelolactone, ( e ) (−)–gallocatechin gallate, ( f ) melanin, ( g ) β,β–dimethylacrylalkannin, ( h ) hematoxylin to M pro (PDB code: 7RFS) active site. The red and blue colors on the protein surface are the surface electrostatic potential, with red representing negative charge and blue representing positive charge.

Journal: Pharmaceuticals

Article Title: Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 M pro

doi: 10.3390/ph16050767

Figure Lengend Snippet: Binding pattern of compounds ( a ) baicalein, ( b ) cholesteryl sodium sulfate, ( c ) ginkgolic acid C15:1, ( d ) wedelolactone, ( e ) (−)–gallocatechin gallate, ( f ) melanin, ( g ) β,β–dimethylacrylalkannin, ( h ) hematoxylin to M pro (PDB code: 7RFS) active site. The red and blue colors on the protein surface are the surface electrostatic potential, with red representing negative charge and blue representing positive charge.

Article Snippet: The Natural Product Library for HTS (catalog number L6000, 50 μL per hole, 10 mM, TargetMol, Shanghai, China, September 2020) was purchased from Shanghai Taosu Biochemical Technology Co., Ltd., including the following: fraxetin (catalog number T2909, TargetMol), vanitiolide (catalog number T0243, TargetMol), (−)–gallocatechin gallate (catalog number T3807, TargetMol), hematoxylin (catalog number T1686, TargetMol), wedelolactone (catalog number T3384, TargetMol), β,β–dimethylacrylalkannin (catalog number T5703, TargetMol), hydroxytyrosol acetate (catalog number T8168, TargetMol), cholesteryl sodium sulfate (catalog number T5239, TargetMol), ginkgolic acid C15:1 (catalog number T6S2123, TargetMol), melanin (catalog number HY-113485, MedChemExpress, Shanghai, China), baicalein (catalog number T2858, TargetMol), sanguinarine (catalog number T2781, TargetMol), corylifol A (catalog number T4S0145, TargetMol), M pro fluorescent substrate (MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2,C223JGC240-1/PE0977, GenScript, Nanjing, China), Sensor Chip SA (10291121, GE Healthcare, Shanghai, China), NHS-PEG12-Biotin (21313, Thermo Scientific, Beijing, China), ultrafiltration centrifuge tube (UFC901096, Millipore), 96-well Microtiter™ microplate (2305-11, Thermo Scientific), black 96-well plate (655077, Greiner Bio-One, Beijing, China), Triton™ X-100 (T109026, Aladdin, Beijing, China), Eppendorf tube (23-2052LK, Crystalgen, Beijing, China).

Techniques: Binding Assay

Compounds screening systems.

Journal: Pharmaceuticals

Article Title: Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 M pro

doi: 10.3390/ph16050767

Figure Lengend Snippet: Compounds screening systems.

Article Snippet: The Natural Product Library for HTS (catalog number L6000, 50 μL per hole, 10 mM, TargetMol, Shanghai, China, September 2020) was purchased from Shanghai Taosu Biochemical Technology Co., Ltd., including the following: fraxetin (catalog number T2909, TargetMol), vanitiolide (catalog number T0243, TargetMol), (−)–gallocatechin gallate (catalog number T3807, TargetMol), hematoxylin (catalog number T1686, TargetMol), wedelolactone (catalog number T3384, TargetMol), β,β–dimethylacrylalkannin (catalog number T5703, TargetMol), hydroxytyrosol acetate (catalog number T8168, TargetMol), cholesteryl sodium sulfate (catalog number T5239, TargetMol), ginkgolic acid C15:1 (catalog number T6S2123, TargetMol), melanin (catalog number HY-113485, MedChemExpress, Shanghai, China), baicalein (catalog number T2858, TargetMol), sanguinarine (catalog number T2781, TargetMol), corylifol A (catalog number T4S0145, TargetMol), M pro fluorescent substrate (MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2,C223JGC240-1/PE0977, GenScript, Nanjing, China), Sensor Chip SA (10291121, GE Healthcare, Shanghai, China), NHS-PEG12-Biotin (21313, Thermo Scientific, Beijing, China), ultrafiltration centrifuge tube (UFC901096, Millipore), 96-well Microtiter™ microplate (2305-11, Thermo Scientific), black 96-well plate (655077, Greiner Bio-One, Beijing, China), Triton™ X-100 (T109026, Aladdin, Beijing, China), Eppendorf tube (23-2052LK, Crystalgen, Beijing, China).

Techniques: Positive Control, Negative Control

Figure 2 Baicalein can inhibit increased 12-LOX levels in irradiated cells. (A) 12-LOX protein levels decreased in a dose-dependent manner after 24-h baicalein treatment (0, 20, 40, or 80 µmol/L) in Eca109 cells. (B and C) Increased expression of 12-LOX after radiation was inhibited in the baicalein-treated group in Eca109 and Kyse150 cells. Experimental data were obtained from three independent tests.***P < 0.001.

Journal: OncoTargets and Therapy

Article Title:

Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages

doi: 10.2147/ott.s257852

Figure Lengend Snippet: Figure 2 Baicalein can inhibit increased 12-LOX levels in irradiated cells. (A) 12-LOX protein levels decreased in a dose-dependent manner after 24-h baicalein treatment (0, 20, 40, or 80 µmol/L) in Eca109 cells. (B and C) Increased expression of 12-LOX after radiation was inhibited in the baicalein-treated group in Eca109 and Kyse150 cells. Experimental data were obtained from three independent tests.***P < 0.001.

Article Snippet: Baicalein (Selleckchem, Houston, TX, USA) is a wellrecognized 12-LOX inhibitor.

Techniques: Irradiation, Expressing

Figure 4 12-LOX modulates CCL5 expression in cancer cells through the AKT/NF-κB pathway. (A and B) Inhibition of 12-LOX, p-AKT, or p-p65 decreased CCL5 expression in Eca109 cells. (C and D) 12-LOX overexpression increased CCL5 levels, which were inhibited by treatment with baicalein, LY294002, or CAPE in Kyse150lv cells. (E) Lower mRNA levels for CCL2, CCL5, CCL22, CSF1, VEGF, TGF-β1, and IL-4 in Eca109B cells compared with Eca109 cells. Experimental data were obtained from three independent tests. *P < 0.05; **P < 0.01; ***P < 0.001. Abbreviation: ns, no significance.

Journal: OncoTargets and Therapy

Article Title:

Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages

doi: 10.2147/ott.s257852

Figure Lengend Snippet: Figure 4 12-LOX modulates CCL5 expression in cancer cells through the AKT/NF-κB pathway. (A and B) Inhibition of 12-LOX, p-AKT, or p-p65 decreased CCL5 expression in Eca109 cells. (C and D) 12-LOX overexpression increased CCL5 levels, which were inhibited by treatment with baicalein, LY294002, or CAPE in Kyse150lv cells. (E) Lower mRNA levels for CCL2, CCL5, CCL22, CSF1, VEGF, TGF-β1, and IL-4 in Eca109B cells compared with Eca109 cells. Experimental data were obtained from three independent tests. *P < 0.05; **P < 0.01; ***P < 0.001. Abbreviation: ns, no significance.

Article Snippet: Baicalein (Selleckchem, Houston, TX, USA) is a wellrecognized 12-LOX inhibitor.

Techniques: Expressing, Inhibition, Over Expression

General effects of the analyzed antioxidants on the dopaminergic neurotransmission.

Journal: Current Neuropharmacology

Article Title: Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease

doi: 10.2174/1570159X19666210421092725

Figure Lengend Snippet: General effects of the analyzed antioxidants on the dopaminergic neurotransmission.

Article Snippet: Baicalin , Sprague-Dawley rats , 6-OHDA , 4 weeks , 25 mg/kg/day , ↑ mTOR, p-mTOR ↑ Akt, p-Akt ↑ GSK-3β, p-GSK-3β Neuroprotective effect mediated by mTOR/Akt/GSK-3β signaling , [ ] .

Techniques: