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Image Search Results
Journal: Acta Neuropathologica
Article Title: A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson’s disease
doi: 10.1007/s00401-025-02853-y
Figure Lengend Snippet: Comparison of CSF SAA results between PD/DLB and other neurodegenerative entities. PD Parkinson’s disease, DLB dementia with Lewy bodies, CON control, MSA multiple system atrophy, PSP progressive supranuclear palsy, AD Alzheimer’s disease, FTD frontotemporal dementia, RFU relative fluorescence units, AUC area under curve, F max maximum fluorescence, TTT time to threshold, av.: average. a The curve characteristics of individual SAA reactions split for diagnoses are presented for PD/DLB (red, n = 46), MSA (blue, n = 31), PSP (yellow, n = 32), and CON (green, n = 20), highlighting the Lewy-fold specificity of the SAA for PD/DLB cases compared to no SAA reactions in MSA and CON cases that stay negative for 144 h. RFU values are normalized to the maximum intensity of fluorescence of the respective experimental plate. Each curve represents the average of the group ± standard error of the mean. b Comparison of the AUC of each group; each point depicts the median AUC for the replicates of the respective individual. c Comparison of the F max of each group; each point depicts the median F max for the replicates of the respective individual. Statistical analyses were conducted using Wilcoxon tests, resulting in a significance of p < 0.0001 (****) between PD/DLB against the other groups, except for FTD (** p ≤ 0.01)
Article Snippet: Of note, 2 publications compared different SAAs in the same study: Russo et al. [ ] analyzed F max ,
Techniques: Comparison, Control, Fluorescence
Journal: Acta Neuropathologica
Article Title: A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson’s disease
doi: 10.1007/s00401-025-02853-y
Figure Lengend Snippet: Correlation of different SAA parameters with core clinical features
Article Snippet: Of note, 2 publications compared different SAAs in the same study: Russo et al. [ ] analyzed F max ,
Techniques: