atr Search Results


mkii golden gate single reflection atr system  (Revvity)
92
Revvity mkii golden gate single reflection atr system
Mkii Golden Gate Single Reflection Atr System, supplied by Revvity, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp atr hs00992123 m1  (Thermo Fisher)
95
Thermo Fisher gene exp atr hs00992123 m1
Gene network affected by osmotic stress regulating H2AX phosphorylation (modulated after ). H2AX phosphorylation is a key event during DNA damage repair. ATM and <t>ATR</t> phosphorylate H2AX upon DNA damage. Dephosphorylation is controlled by PP4, which is inhibited by CCDC6. Arrows indicate gene expression changes after osmotic stress. The table shows the log2 fold changes and p -values of respective genes after cultivation under osmotic stress conditions for 6 and 12 h ( n = 3).
Gene Exp Atr Hs00992123 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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multimab rabbit monoclonal antibody mix  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc multimab rabbit monoclonal antibody mix
Gene network affected by osmotic stress regulating H2AX phosphorylation (modulated after ). H2AX phosphorylation is a key event during DNA damage repair. ATM and <t>ATR</t> phosphorylate H2AX upon DNA damage. Dephosphorylation is controlled by PP4, which is inhibited by CCDC6. Arrows indicate gene expression changes after osmotic stress. The table shows the log2 fold changes and p -values of respective genes after cultivation under osmotic stress conditions for 6 and 12 h ( n = 3).
Multimab Rabbit Monoclonal Antibody Mix, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 95 stars, based on 1 article reviews
multimab rabbit monoclonal antibody mix - by Bioz Stars, 2026-03
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rabbit anti patr  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc rabbit anti patr
Gene network affected by osmotic stress regulating H2AX phosphorylation (modulated after ). H2AX phosphorylation is a key event during DNA damage repair. ATM and <t>ATR</t> phosphorylate H2AX upon DNA damage. Dephosphorylation is controlled by PP4, which is inhibited by CCDC6. Arrows indicate gene expression changes after osmotic stress. The table shows the log2 fold changes and p -values of respective genes after cultivation under osmotic stress conditions for 6 and 12 h ( n = 3).
Rabbit Anti Patr, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
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atr  (Bethyl)
93
Bethyl atr
Figure <t>4.</t> <t>ATM-</t> and <t>ATR-dependency</t> of TIFs formation in late S/G2 in pre-senescent fibroblasts. (A) Images of 53BP1 or g-H2AX immunoFISH detection in Cyclin A-positive pre-senescent cells treated as indicated. Pre-senescent HFF cells (PD69) were treated with caffeine or transfected with siATM or siATR or siGFP and immunolabelled with anti-53BP1, anti-g-H2AX, (red) and Cyclin A antibodies and processed by PNA-FISH to visualize telomeres (TTAGGG, green). (B) Enlarged colocalizing foci images, including the areas marked with white rectangles in (A). (C) Quantification of Cyclin A-positive cells exhibiting more than four g-H2AX or 53BP1 telomeric foci (TIFs) in pre-senescent cells following incubation with caffeine or transfection with siATM, siATR or siGFP. Cells were prepared 48 h after transfection as in (A). The mean (±SD) of three independent experiments is reported. Statistical significance of the differences between untreated and treated cultures was assessed by Student’s t-test (**P < 0.001).
Atr, supplied by Bethyl, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
atr - by Bioz Stars, 2026-03
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atr  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc atr
Figure <t>4.</t> <t>ATM-</t> and <t>ATR-dependency</t> of TIFs formation in late S/G2 in pre-senescent fibroblasts. (A) Images of 53BP1 or g-H2AX immunoFISH detection in Cyclin A-positive pre-senescent cells treated as indicated. Pre-senescent HFF cells (PD69) were treated with caffeine or transfected with siATM or siATR or siGFP and immunolabelled with anti-53BP1, anti-g-H2AX, (red) and Cyclin A antibodies and processed by PNA-FISH to visualize telomeres (TTAGGG, green). (B) Enlarged colocalizing foci images, including the areas marked with white rectangles in (A). (C) Quantification of Cyclin A-positive cells exhibiting more than four g-H2AX or 53BP1 telomeric foci (TIFs) in pre-senescent cells following incubation with caffeine or transfection with siATM, siATR or siGFP. Cells were prepared 48 h after transfection as in (A). The mean (±SD) of three independent experiments is reported. Statistical significance of the differences between untreated and treated cultures was assessed by Student’s t-test (**P < 0.001).
Atr, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/atr/product/Cell Signaling Technology Inc
Average 96 stars, based on 1 article reviews
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anti atr  (Santa Cruz Biotechnology)
94
Santa Cruz Biotechnology anti atr
Figure <t>4.</t> <t>ATM-</t> and <t>ATR-dependency</t> of TIFs formation in late S/G2 in pre-senescent fibroblasts. (A) Images of 53BP1 or g-H2AX immunoFISH detection in Cyclin A-positive pre-senescent cells treated as indicated. Pre-senescent HFF cells (PD69) were treated with caffeine or transfected with siATM or siATR or siGFP and immunolabelled with anti-53BP1, anti-g-H2AX, (red) and Cyclin A antibodies and processed by PNA-FISH to visualize telomeres (TTAGGG, green). (B) Enlarged colocalizing foci images, including the areas marked with white rectangles in (A). (C) Quantification of Cyclin A-positive cells exhibiting more than four g-H2AX or 53BP1 telomeric foci (TIFs) in pre-senescent cells following incubation with caffeine or transfection with siATM, siATR or siGFP. Cells were prepared 48 h after transfection as in (A). The mean (±SD) of three independent experiments is reported. Statistical significance of the differences between untreated and treated cultures was assessed by Student’s t-test (**P < 0.001).
Anti Atr, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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patm atr substrate  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc patm atr substrate
Figure <t>4.</t> <t>ATM-</t> and <t>ATR-dependency</t> of TIFs formation in late S/G2 in pre-senescent fibroblasts. (A) Images of 53BP1 or g-H2AX immunoFISH detection in Cyclin A-positive pre-senescent cells treated as indicated. Pre-senescent HFF cells (PD69) were treated with caffeine or transfected with siATM or siATR or siGFP and immunolabelled with anti-53BP1, anti-g-H2AX, (red) and Cyclin A antibodies and processed by PNA-FISH to visualize telomeres (TTAGGG, green). (B) Enlarged colocalizing foci images, including the areas marked with white rectangles in (A). (C) Quantification of Cyclin A-positive cells exhibiting more than four g-H2AX or 53BP1 telomeric foci (TIFs) in pre-senescent cells following incubation with caffeine or transfection with siATM, siATR or siGFP. Cells were prepared 48 h after transfection as in (A). The mean (±SD) of three independent experiments is reported. Statistical significance of the differences between untreated and treated cultures was assessed by Student’s t-test (**P < 0.001).
Patm Atr Substrate, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit monoclonal anti patr  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc rabbit monoclonal anti patr
Figure <t>4.</t> <t>ATM-</t> and <t>ATR-dependency</t> of TIFs formation in late S/G2 in pre-senescent fibroblasts. (A) Images of 53BP1 or g-H2AX immunoFISH detection in Cyclin A-positive pre-senescent cells treated as indicated. Pre-senescent HFF cells (PD69) were treated with caffeine or transfected with siATM or siATR or siGFP and immunolabelled with anti-53BP1, anti-g-H2AX, (red) and Cyclin A antibodies and processed by PNA-FISH to visualize telomeres (TTAGGG, green). (B) Enlarged colocalizing foci images, including the areas marked with white rectangles in (A). (C) Quantification of Cyclin A-positive cells exhibiting more than four g-H2AX or 53BP1 telomeric foci (TIFs) in pre-senescent cells following incubation with caffeine or transfection with siATM, siATR or siGFP. Cells were prepared 48 h after transfection as in (A). The mean (±SD) of three independent experiments is reported. Statistical significance of the differences between untreated and treated cultures was assessed by Student’s t-test (**P < 0.001).
Rabbit Monoclonal Anti Patr, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rabbit monoclonal anti patr/product/Cell Signaling Technology Inc
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mouse atr  (Novus Biologicals)
92
Novus Biologicals mouse atr
Figure <t>4.</t> <t>ATM-</t> and <t>ATR-dependency</t> of TIFs formation in late S/G2 in pre-senescent fibroblasts. (A) Images of 53BP1 or g-H2AX immunoFISH detection in Cyclin A-positive pre-senescent cells treated as indicated. Pre-senescent HFF cells (PD69) were treated with caffeine or transfected with siATM or siATR or siGFP and immunolabelled with anti-53BP1, anti-g-H2AX, (red) and Cyclin A antibodies and processed by PNA-FISH to visualize telomeres (TTAGGG, green). (B) Enlarged colocalizing foci images, including the areas marked with white rectangles in (A). (C) Quantification of Cyclin A-positive cells exhibiting more than four g-H2AX or 53BP1 telomeric foci (TIFs) in pre-senescent cells following incubation with caffeine or transfection with siATM, siATR or siGFP. Cells were prepared 48 h after transfection as in (A). The mean (±SD) of three independent experiments is reported. Statistical significance of the differences between untreated and treated cultures was assessed by Student’s t-test (**P < 0.001).
Mouse Atr, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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protein git1  (Cell Signaling Technology Inc)
94
Cell Signaling Technology Inc protein git1
Figure <t>4.</t> <t>ATM-</t> and <t>ATR-dependency</t> of TIFs formation in late S/G2 in pre-senescent fibroblasts. (A) Images of 53BP1 or g-H2AX immunoFISH detection in Cyclin A-positive pre-senescent cells treated as indicated. Pre-senescent HFF cells (PD69) were treated with caffeine or transfected with siATM or siATR or siGFP and immunolabelled with anti-53BP1, anti-g-H2AX, (red) and Cyclin A antibodies and processed by PNA-FISH to visualize telomeres (TTAGGG, green). (B) Enlarged colocalizing foci images, including the areas marked with white rectangles in (A). (C) Quantification of Cyclin A-positive cells exhibiting more than four g-H2AX or 53BP1 telomeric foci (TIFs) in pre-senescent cells following incubation with caffeine or transfection with siATM, siATR or siGFP. Cells were prepared 48 h after transfection as in (A). The mean (±SD) of three independent experiments is reported. Statistical significance of the differences between untreated and treated cultures was assessed by Student’s t-test (**P < 0.001).
Protein Git1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Gene network affected by osmotic stress regulating H2AX phosphorylation (modulated after ). H2AX phosphorylation is a key event during DNA damage repair. ATM and ATR phosphorylate H2AX upon DNA damage. Dephosphorylation is controlled by PP4, which is inhibited by CCDC6. Arrows indicate gene expression changes after osmotic stress. The table shows the log2 fold changes and p -values of respective genes after cultivation under osmotic stress conditions for 6 and 12 h ( n = 3).

Journal: Cells

Article Title: Osmotic Stress Interferes with DNA Damage Response and H2AX Phosphorylation in Human Keratinocytes

doi: 10.3390/cells11060959

Figure Lengend Snippet: Gene network affected by osmotic stress regulating H2AX phosphorylation (modulated after ). H2AX phosphorylation is a key event during DNA damage repair. ATM and ATR phosphorylate H2AX upon DNA damage. Dephosphorylation is controlled by PP4, which is inhibited by CCDC6. Arrows indicate gene expression changes after osmotic stress. The table shows the log2 fold changes and p -values of respective genes after cultivation under osmotic stress conditions for 6 and 12 h ( n = 3).

Article Snippet: ATM (Assay ID: Hs00175892_m1), ATR (Assay ID: Hs00992123_m1), PP4 (Assay ID: Hs00908713_m1), CCDC6 (Assay ID: Hs00193731_m1), 18S (Assay ID: Hs99999901_s1).

Techniques: Phospho-proteomics, De-Phosphorylation Assay, Gene Expression

Figure 4. ATM- and ATR-dependency of TIFs formation in late S/G2 in pre-senescent fibroblasts. (A) Images of 53BP1 or g-H2AX immunoFISH detection in Cyclin A-positive pre-senescent cells treated as indicated. Pre-senescent HFF cells (PD69) were treated with caffeine or transfected with siATM or siATR or siGFP and immunolabelled with anti-53BP1, anti-g-H2AX, (red) and Cyclin A antibodies and processed by PNA-FISH to visualize telomeres (TTAGGG, green). (B) Enlarged colocalizing foci images, including the areas marked with white rectangles in (A). (C) Quantification of Cyclin A-positive cells exhibiting more than four g-H2AX or 53BP1 telomeric foci (TIFs) in pre-senescent cells following incubation with caffeine or transfection with siATM, siATR or siGFP. Cells were prepared 48 h after transfection as in (A). The mean (±SD) of three independent experiments is reported. Statistical significance of the differences between untreated and treated cultures was assessed by Student’s t-test (**P < 0.001).

Journal: Nucleic acids research

Article Title: Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response.

doi: 10.1093/nar/gks1121

Figure Lengend Snippet: Figure 4. ATM- and ATR-dependency of TIFs formation in late S/G2 in pre-senescent fibroblasts. (A) Images of 53BP1 or g-H2AX immunoFISH detection in Cyclin A-positive pre-senescent cells treated as indicated. Pre-senescent HFF cells (PD69) were treated with caffeine or transfected with siATM or siATR or siGFP and immunolabelled with anti-53BP1, anti-g-H2AX, (red) and Cyclin A antibodies and processed by PNA-FISH to visualize telomeres (TTAGGG, green). (B) Enlarged colocalizing foci images, including the areas marked with white rectangles in (A). (C) Quantification of Cyclin A-positive cells exhibiting more than four g-H2AX or 53BP1 telomeric foci (TIFs) in pre-senescent cells following incubation with caffeine or transfection with siATM, siATR or siGFP. Cells were prepared 48 h after transfection as in (A). The mean (±SD) of three independent experiments is reported. Statistical significance of the differences between untreated and treated cultures was assessed by Student’s t-test (**P < 0.001).

Article Snippet: Primary antibodies were as follows: anti-p53 (DO-1), -p21Waf1 (sc-347), -Chk1 (G4), -Cdk2 (sc-163), Cdk4 (sc-260), Cyclin E (HE-12) (Santa Cruz Biotechnology), -S15-p53, -T68-Chk2, -S345Chk1-S317-Chk1, S1981-ATM (10H11.E12) (all from D ow nloaded from https://academ ic.oup.com /nar/article/41/2/900/1064001 by guest on 20 M arch 2025 Cell Signaling Technology), -Chk2 (clone 7, Millipore), -ATM, -ATR, hRap1 (Bethyl Laboratories), -p16INK4a (G175-405), -pRB (G3-245), -Cyclin D1 (G124-326, Bio sciences Pharmingen), Histone H3, g-H2AX (JBW301, Upstate Biotechnology), -TRF2 (4A794, Imgenex), -TRF1 (57-6, Novus Biologicals and TRF-78, Abcam), -POT1 (Novus Biologicals), -TIN2 (gift of S-H Kim, Detroit, USA), -Cyclin A (6E6, Novocastra), -Flag (F-7425), -g-Tubulin (GTU 88) and -a-Tubulin (DM1A) (Sigma).

Techniques: Transfection, Incubation