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Roche
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Revvity
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Danaher Inc
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Cytiva Europe
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Akoya Biosciences
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Cytiva Europe
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Image Search Results
Journal: Human reproduction (Oxford, England)
Article Title: Defining the limits of detection for chromosome rearrangements in the preimplantation embryo using next generation sequencing.
doi: 10.1093/humrep/dey227
Figure Lengend Snippet: Figure 3 An example of how poor data quality can impact the detection of unbalanced chromosome segments for embryos from a 46,XX,t(2;9) (p24;q33) translocation carrier using next generation sequencing (NGS). The same SurePlex product is shown in both A and B. All quality control (QC) measures were above the acceptable level recommended by the manufacturer. (A) Shows the sample from a run with high data quality which resulted in the detection of the chromosome 2 duplication (2pter–2p25.1). (B) Shows the same sample from a run with suboptimal data quality (the number of reads passing filter were just above 250 000, which was well below the optimal 500 000 reads) which resulted in lack of detection of the chromosome 2 duplication.
Article Snippet: WGA was performed using the
Techniques: Translocation Assay, Next-Generation Sequencing, Control