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  • 92
    Amgen amg2850
    Amg2850, supplied by Amgen, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/amg2850/product/Amgen
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    amg2850 - by Bioz Stars, 2022-10
    92/100 stars
      Buy from Supplier

    92
    Alomone Labs amg2850
    Body temperature on the day 7, after the injection of the TRPM8 antagonist <t>AMG2850</t> ( a ) and of the vehicle ( b ). The values are expressed as mean ± s.e.m. Arrow indicates the time of AMG2850 injection. Grey areas indicate the period of RF exposure for the EXPO groups. *p
    Amg2850, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/amg2850/product/Alomone Labs
    Average 92 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    amg2850 - by Bioz Stars, 2022-10
    92/100 stars
      Buy from Supplier

    85
    Amgen reagents amg2850
    a Intraperitoneal injection of icilin induces wet-dog shakes (WDS) in a dose-dependent manner. b <t>AMG2850</t> reduces WDS in a dose- and plasma concentration-dependent manner. c AMG2850 (10 mg/kg, p.o.) significantly and fully blocked the cold pressor effect (*** p
    Reagents Amg2850, supplied by Amgen, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/reagents amg2850/product/Amgen
    Average 85 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    reagents amg2850 - by Bioz Stars, 2022-10
    85/100 stars
      Buy from Supplier

    Image Search Results


    Body temperature on the day 7, after the injection of the TRPM8 antagonist AMG2850 ( a ) and of the vehicle ( b ). The values are expressed as mean ± s.e.m. Arrow indicates the time of AMG2850 injection. Grey areas indicate the period of RF exposure for the EXPO groups. *p

    Journal: Scientific Reports

    Article Title: Effect of non-thermal radiofrequency on body temperature in mice

    doi: 10.1038/s41598-020-62789-z

    Figure Lengend Snippet: Body temperature on the day 7, after the injection of the TRPM8 antagonist AMG2850 ( a ) and of the vehicle ( b ). The values are expressed as mean ± s.e.m. Arrow indicates the time of AMG2850 injection. Grey areas indicate the period of RF exposure for the EXPO groups. *p

    Article Snippet: Thirty minutes prior to the onset of RF exposure in the morning of the seventh day, a TRPM8 channel antagonist, AMG2850 (Alomone Labs, Jerusalem, Israel), was injected intra-peritoneally at a dose of 30 mg.kg−1 in 5 mice of the SHAM group (called SHAM-ANT group) and 6 mice of the EXPO group (called EXPO-ANT group).

    Techniques: Injection

    a Intraperitoneal injection of icilin induces wet-dog shakes (WDS) in a dose-dependent manner. b AMG2850 reduces WDS in a dose- and plasma concentration-dependent manner. c AMG2850 (10 mg/kg, p.o.) significantly and fully blocked the cold pressor effect (*** p

    Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

    Article Title: AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

    doi: 10.1007/s00210-015-1090-9

    Figure Lengend Snippet: a Intraperitoneal injection of icilin induces wet-dog shakes (WDS) in a dose-dependent manner. b AMG2850 reduces WDS in a dose- and plasma concentration-dependent manner. c AMG2850 (10 mg/kg, p.o.) significantly and fully blocked the cold pressor effect (*** p

    Article Snippet: Compounds and reagents AMG2850, which was synthesized at Amgen Inc (Thousand Oaks, CA), resulted from an internal medicinal chemistry effort (Horne et al. ).

    Techniques: Injection, Concentration Assay

    a AMG2850 did not affect the total distance traveled in reversed light cycle rat open field boxes ( p > 0.05) while the positive control compound chlordiazepoxide (CDP; 5.6 mg/kg) significantly reduced distance traveled (* p

    Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

    Article Title: AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

    doi: 10.1007/s00210-015-1090-9

    Figure Lengend Snippet: a AMG2850 did not affect the total distance traveled in reversed light cycle rat open field boxes ( p > 0.05) while the positive control compound chlordiazepoxide (CDP; 5.6 mg/kg) significantly reduced distance traveled (* p

    Article Snippet: Compounds and reagents AMG2850, which was synthesized at Amgen Inc (Thousand Oaks, CA), resulted from an internal medicinal chemistry effort (Horne et al. ).

    Techniques: Positive Control

    a AMG2850 potently inhibits both cold temperature- and icilin-induced increase in luminescence believed to reflect intracellular calcium in CHO cells stably expressing rat TRPM8. After a 2-h incubation with coelenterazine, cells were incubated with compounds for 2.5 min prior to the addition of either icilin (1 μM) or cold buffer (12 °C). Luminescence was measured by a CCD camera-based FLASH-luminometer. Concentration-response curves were generated using GraphPad Prism 4.01. Each point in the graphs is an average ± SEM of an experiment conducted in triplicate. Responses of agonists used were normalized to 100 % of maximum. b In a skin-nerve preparation, total percentage of C fibers responding to 300 μM menthol after incubation with vehicle or AMG2850. A response to menthol was defined as three action potentials above baseline over a 2-min interval. Incubation with AMG2850 significantly decreased the percentage of C fibers responding to menthol as compared to vehicle controls (** p

    Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

    Article Title: AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

    doi: 10.1007/s00210-015-1090-9

    Figure Lengend Snippet: a AMG2850 potently inhibits both cold temperature- and icilin-induced increase in luminescence believed to reflect intracellular calcium in CHO cells stably expressing rat TRPM8. After a 2-h incubation with coelenterazine, cells were incubated with compounds for 2.5 min prior to the addition of either icilin (1 μM) or cold buffer (12 °C). Luminescence was measured by a CCD camera-based FLASH-luminometer. Concentration-response curves were generated using GraphPad Prism 4.01. Each point in the graphs is an average ± SEM of an experiment conducted in triplicate. Responses of agonists used were normalized to 100 % of maximum. b In a skin-nerve preparation, total percentage of C fibers responding to 300 μM menthol after incubation with vehicle or AMG2850. A response to menthol was defined as three action potentials above baseline over a 2-min interval. Incubation with AMG2850 significantly decreased the percentage of C fibers responding to menthol as compared to vehicle controls (** p

    Article Snippet: Compounds and reagents AMG2850, which was synthesized at Amgen Inc (Thousand Oaks, CA), resulted from an internal medicinal chemistry effort (Horne et al. ).

    Techniques: Stable Transfection, Expressing, Incubation, Concentration Assay, Generated