alkaloid compound library Search Results


alkaloid natural product library  (TargetMol)
94
TargetMol alkaloid natural product library
Alkaloid Natural Product Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/alkaloid+compound+library/Alkaloid+Natural+Product+Library/pmc09701226-167-0-7
Average 94 stars, based on 1 article reviews
alkaloid natural product library - by Bioz Stars, 2026-11
94/100 stars
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269 compounds  (Selleck Chemicals)
93
Selleck Chemicals 269 compounds
Screening <t>of</t> <t>Alkaloid</t> Compounds Synergistic with Sorafenib in HCC. A Scatter plot showing the combined inhibition rates of <t>269</t> alkaloid compounds (10 µM) when combined with Sora (1 µM). The x-axis represents the number of compounds, while the y-axis displays the inhibition rate. The blue dotted line indicates the inhibition rate of Sora alone (10.3%), and the red dotted line marks the 50% inhibition threshold. The top 20 alkaloids with the highest combined inhibition rates are ranked. B Flowchart for selecting Cory as a candidate Sora sensitizer from the alkaloid library. C CCK8 assay results demonstrating the effects of Cory (10 µM) and/or Sora (1 µM) for 24 h on cell viability in Huh7 and HepG2 cells. D CCK8 assays assessing the impact of Cory (10 µM) on the viability of the HCC cell lines Huh7 and HepG2. E IC 50 values of Cory in Huh7 and HepG2 cells. F Combination index (CI) plot for Cory and Sora in Huh7 and HepG2 cells, with black, red, blue, and green dots representing different treatment concentrations. G CCK8 assays and ( H , I ) colony formation assays in Huh7 and HepG2 cells treated with Sora (1 µM), Cory (10 µM), or their combination. Student’s t-test was applied to compare differences between two groups, while one-way ANOVA was used for comparisons involving four groups. Statistical significance is indicated as follows: **P < 0.01, ***P < 0.001, ns: not significant
269 Compounds, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/alkaloid+compound+library/Alkaloid+Compound+Library/pmc12616971-53-5-10
Average 93 stars, based on 1 article reviews
269 compounds - by Bioz Stars, 2026-11
93/100 stars
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alkaloid compound library  (Aladdin Scientific Corporation)
N/A
•A unique collection of 413 alkaloid compounds used for high throughput screening(HTS) and high content screening(HCS);•Some compounds have been approved by the FDA;•Structurally diverse,medicinally active,and cell permeable;•Rich documentation with structure and bioactivity information;•NMR and HPLC
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Screening of Alkaloid Compounds Synergistic with Sorafenib in HCC. A Scatter plot showing the combined inhibition rates of 269 alkaloid compounds (10 µM) when combined with Sora (1 µM). The x-axis represents the number of compounds, while the y-axis displays the inhibition rate. The blue dotted line indicates the inhibition rate of Sora alone (10.3%), and the red dotted line marks the 50% inhibition threshold. The top 20 alkaloids with the highest combined inhibition rates are ranked. B Flowchart for selecting Cory as a candidate Sora sensitizer from the alkaloid library. C CCK8 assay results demonstrating the effects of Cory (10 µM) and/or Sora (1 µM) for 24 h on cell viability in Huh7 and HepG2 cells. D CCK8 assays assessing the impact of Cory (10 µM) on the viability of the HCC cell lines Huh7 and HepG2. E IC 50 values of Cory in Huh7 and HepG2 cells. F Combination index (CI) plot for Cory and Sora in Huh7 and HepG2 cells, with black, red, blue, and green dots representing different treatment concentrations. G CCK8 assays and ( H , I ) colony formation assays in Huh7 and HepG2 cells treated with Sora (1 µM), Cory (10 µM), or their combination. Student’s t-test was applied to compare differences between two groups, while one-way ANOVA was used for comparisons involving four groups. Statistical significance is indicated as follows: **P < 0.01, ***P < 0.001, ns: not significant

Journal: Chinese Medicine

Article Title: Corynoline enhances sorafenib sensitivity in hepatocellular carcinoma via NOS3-mediated ROS production

doi: 10.1186/s13020-025-01259-y

Figure Lengend Snippet: Screening of Alkaloid Compounds Synergistic with Sorafenib in HCC. A Scatter plot showing the combined inhibition rates of 269 alkaloid compounds (10 µM) when combined with Sora (1 µM). The x-axis represents the number of compounds, while the y-axis displays the inhibition rate. The blue dotted line indicates the inhibition rate of Sora alone (10.3%), and the red dotted line marks the 50% inhibition threshold. The top 20 alkaloids with the highest combined inhibition rates are ranked. B Flowchart for selecting Cory as a candidate Sora sensitizer from the alkaloid library. C CCK8 assay results demonstrating the effects of Cory (10 µM) and/or Sora (1 µM) for 24 h on cell viability in Huh7 and HepG2 cells. D CCK8 assays assessing the impact of Cory (10 µM) on the viability of the HCC cell lines Huh7 and HepG2. E IC 50 values of Cory in Huh7 and HepG2 cells. F Combination index (CI) plot for Cory and Sora in Huh7 and HepG2 cells, with black, red, blue, and green dots representing different treatment concentrations. G CCK8 assays and ( H , I ) colony formation assays in Huh7 and HepG2 cells treated with Sora (1 µM), Cory (10 µM), or their combination. Student’s t-test was applied to compare differences between two groups, while one-way ANOVA was used for comparisons involving four groups. Statistical significance is indicated as follows: **P < 0.01, ***P < 0.001, ns: not significant

Article Snippet: The library of alkaloid products (269 compounds) was obtained from Selleckchem (Selleckchem, L7900, USA).

Techniques: Inhibition, CCK-8 Assay