Journal: PLoS ONE

Article Title: Fibrin Clot Structure and Platelet Aggregation in Patients with Aspirin Treatment Failure

doi: 10.1371/journal.pone.0071150

Figure Lengend Snippet: CAD patients without previous MI compared with CAD patients with previous MI on aspirin (ATF) assesed by turbidimetric clot assays (n = 172) and Multiplate® aggregometry (n = 174), respectively. Results are presented as median±IQR.

Article Snippet: Platelet aggregation was evaluated by 1) multiple electrode aggregometry (MEA) using Multiplate® aggregometer (Dynabyte, Münich, Germany) with arachidonic acid (AA) 1.0 mM, collagen 1.0 μg/mL and adenosine diphosphate (ADP) 10 μM as agonists and by 2) the VerifyNow® Aspirin assay (Accumetrics, CA, USA) as previously described .

Techniques:

Journal: Journal of Translational Medicine

Article Title: Endothelial progenitor cells inhibit platelet function in a P-selectin-dependent manner

doi: 10.1186/s12967-015-0508-y

Figure Lengend Snippet: Effect of EPCs on collagen-induced platelet aggregation. Whole blood was pre-incubated with different concentrations of EPCs in a 4-channel lumi-aggregometer under shear (1,000 rpm) at 37°C. Platelet aggregation was initiated by adding collagen (3 μg/mL) and then monitored for 5 minutes. Representative traces of whole blood platelet aggregation from A) WT and B) P-sel −/− mice. The mean data ± SEM of 5 independent experiments, summarizing the effects of different EPC concentrations on collagen-induced platelet aggregation in WT and P-sel −/− mice are presented in C and D , respectively.

Article Snippet: Blood was then subjected to the aggregation process in a 4 channel whole blood platelet aggregometer (Chrono-log corp., Havertown, PA), as previously described [ - ].

Techniques: Incubation